Publication:
Nitric oxide, erythrocytes and exercise

dc.contributor.coauthorÜlker, Pınar
dc.contributor.coauthorMeiselman, Herbert J.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBaşkurt, Oğuz Kerim
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T22:50:13Z
dc.date.issued2011
dc.description.abstractNitric oxide (NO) is accepted to be an important factor affecting the degree of vascular tone in various portions of the circulation. Until recently, research in this area has focused on endothelial cells as a NO source, and there is general agreement that: 1) the level of wall shear stress is the primary determinant of endothelial nitric oxide synthase (eNOS) expression; 2) exercise training induces changes of endothelial cell NO synthesizing activity; 3) phosphorylation patterns of eNOS are altered following exercise episodes. However, there is now a growing body of evidence for the existence of similar nitric oxide synthesizing mechanisms in human red blood cells (RBC). Erythrocyte NOS activity has been demonstrated to be induced by applied shear stress and mechanical deformation of RBC, and there are closely linked increases of intracellular nitric oxide levels and of release of NO into the suspending phase. In brief, the RBC is an enzymatic source of NO that is dependent on flow dynamics and from which NO is released in very close proximity to vessel walls. Although reports regarding the influence of exercise on RBC nitric oxide synthesizing mechanisms are not yet concordant, it seems logical to suggest that this source of NO may play a role in the regulation of local blood flow dynamics during exercise.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue45017
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume49
dc.identifier.doi10.3233/CH-2011-1467
dc.identifier.eissn1875-8622
dc.identifier.issn1386-0291
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-84856906012
dc.identifier.urihttps://doi.org/10.3233/CH-2011-1467
dc.identifier.urihttps://hdl.handle.net/20.500.14288/6637
dc.identifier.wos298858400017
dc.keywordsNitric oxide
dc.keywordsExercise
dc.keywordsShear stress
dc.keywordsENOS
dc.keywordsPhosphorylation
dc.language.isoeng
dc.publisherIOS Press
dc.relation.ispartofClinical Hemorheology and Microcirculation
dc.subjectHematology
dc.subjectPeripheral vascular disease
dc.titleNitric oxide, erythrocytes and exercise
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorBaşkurt, Oğuz Kerim
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

Files