Publication:
Is the presence of AA amyloidosis associated with impaired coronary flow reserve?

dc.contributor.coauthorBulut, Mustafa
dc.contributor.coauthorKeles, Nursen
dc.contributor.coauthorCaliskan, Zuhal
dc.contributor.coauthorKostek, Osman
dc.contributor.coauthorAksu, Feyza
dc.contributor.coauthorOzdil, Kamil
dc.contributor.coauthorAkcakoyun, Mustafa
dc.contributor.coauthorDemircioglu, Kenan
dc.contributor.coauthorYilmaz, Yusuf
dc.contributor.coauthorCaliskan, Mustafa
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:04:53Z
dc.date.issued2016
dc.description.abstractBackground and aims: Systemic amyloid A protein (AA) amyloidosis may occur as a complication of many chronic inflammatory disorders. Patients receiving inadequate anti-inflammatory and immunosuppressive therapies have an increased risk of developing systemic AA amyloidosis. Inflammation plays a role in all stages and the thrombotic complications of atherosclerosis. In the absence of epicardial coronary stenosis, coronary flow reserve (CFR) reflects coronary microvascular dysfunction. In the present study, we hypothesized that amyloid advanced subclinical inflammation in chronic inflammatory diseases (CID) patients may further affect coronary microcirculation. Methods: Thirty-two patients with biopsy-diagnosed renal AA, 73 patients with non-amyloid CID, and a group of healthy volunteers were included in the study. The measurements of coronary flow velocity were performed by a single investigator with expertise in transthoracic Doppler harmonic echocardiography (TTDE). Results: The AA amyloidosis subgroup had significantly lower CFR values than other non-amyloid CID patients and the control individuals (1.8 (1.5-2.1) vs. 2.1 (2.0-2.4) and 3.0 (2.8-3.2), p < 0.001). Multivariate logistic regression analysis indicated that the presence of AA amyloidosis and elevated hs - CRP independently predict impairment of the CFR (p < 0.05). Conclusions: The presence of AA amyloidosis is related to decreased CFR values and the presence of AA amyloidosis and elevated hs - CRP independently predict impairment of the CFR. Therefore, patients with AA amyloidosis may have an increased risk of developing coronary artery diseases.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume251
dc.identifier.doi10.1016/j.atherosclerosis.2016.05.041
dc.identifier.eissn1879-1484
dc.identifier.issn0021-9150
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-84971601473
dc.identifier.urihttps://doi.org/10.1016/j.atherosclerosis.2016.05.041
dc.identifier.urihttps://hdl.handle.net/20.500.14288/8714
dc.identifier.wos381262100056
dc.keywordsAA amyloidosis
dc.keywordsCoronary flow reserve
dc.keywordsAtherosclerosis
dc.keywordsTransesophageal doppler-echocardiography
dc.keywordsNoninvasive assessment
dc.keywordsMicrovascular dysfunction
dc.keywordsBlood-flow
dc.keywordsVelocity
dc.keywordsArtery
dc.keywordsInflammation
dc.keywordsFeasibility
dc.keywordsCommittee
dc.keywordsDisease
dc.language.isoeng
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofAtherosclerosis
dc.subjectCardiac
dc.subjectCardiovascular systems
dc.subjectPeripheral vascular disease
dc.titleIs the presence of AA amyloidosis associated with impaired coronary flow reserve?
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKanbay, Mehmet
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

Files