Publication:
Recurrent implantation failure: a plea for a widely adopted rational definition

dc.contributor.coauthorSomigliana, Edgardo
dc.contributor.coauthorBusnelli, Andrea
dc.contributor.coauthorVigano, Paola
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAta, Mustafa Barış
dc.contributor.kuauthorKalafat, Erkan
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-10T00:00:12Z
dc.date.issued2022
dc.description.abstractMost proposed definitions of recurrent implantation failure (RIF) are based on clinical judgement, probably affected by patients’ demands. They are not based on robust statistical considerations. As a result, a diagnosis of RIF is commonly made too early, exposing couples to the risk of overdiagnosis and overtreatment. However, the situation is changing, and three statistical approaches have recently been proposed. The first is a probability model based on the chances of success per cycle and suggests for the definition three failed oocyte retrieval cycles with all embryos being transferred in women younger than 40 years of age. The second approach suggests an individualized diagnosis that takes into consideration multiple factors, while the third is also based on individualization but mainly relies on anticipated euploidy rates across the female age range. All these approaches have their pros and cons. Regardless of the specific peculiarities, they represent steps in the right direction, with the intent of providing a statistically sound definition. However, these attempts will not be useful unless endorsed by the scientific community in general. There is a pressing need for a rigorous and shared definition of RIF that will be widely accepted by researchers, scientific societies and other stakeholders, including patients.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume45
dc.identifier.doi10.1016/j.rbmo.2022.01.011
dc.identifier.eissn1472-6491
dc.identifier.issn1472-6483
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85126782551
dc.identifier.urihttps://doi.org/10.1016/j.rbmo.2022.01.011
dc.identifier.urihttps://hdl.handle.net/20.500.14288/15766
dc.identifier.wos870291400001
dc.keywordsAneuploidy
dc.keywordsIVF
dc.keywordsRecurrent implantation failure
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofReproductive Biomedicine Online
dc.subjectObstetrics
dc.subjectGynecology
dc.subjectReproductive biology
dc.titleRecurrent implantation failure: a plea for a widely adopted rational definition
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKalafat, Erkan
local.contributor.kuauthorAta, Mustafa Barış
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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