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Birth outcomes in pregnant women with epilepsy: A Nationwide multicenter study from Türkiye

dc.contributor.coauthorPekoz, Mehmet Taylan
dc.contributor.coauthorAslan-Kara, Kezban
dc.contributor.coauthorTekin, Betul
dc.contributor.coauthorYeni, Seher Naz
dc.contributor.coauthorBozdemir, Hacer
dc.contributor.coauthorKeskin-Guler, Selda
dc.contributor.coauthorAtakli, Dilek
dc.contributor.coauthorGul, Gunay
dc.contributor.coauthorEren, Fulya
dc.contributor.coauthorSari, Huseyin
dc.contributor.coauthorGul, Zeynep Bastug
dc.contributor.coauthorCeyhan-Dirican, Ayten
dc.contributor.coauthorGenc, Fatma
dc.contributor.coauthorBicer-Gomceli, Yasemin
dc.contributor.coauthorOzkara, Cigdem
dc.contributor.coauthorDelil, Sakir
dc.contributor.coauthorAtalar, Arife Cimen
dc.contributor.coauthorBebek, Nerses
dc.contributor.coauthorBaykan, Betul
dc.contributor.coauthorBora, Ibrahim
dc.contributor.coauthorBican-Demir, Aylin
dc.contributor.coauthorMisirli, Cemile Handan
dc.contributor.coauthorTutkavul, Kemal
dc.contributor.coauthorVelioglu, Sibel K. K.
dc.contributor.coauthorIlhan-Algin, Demet
dc.contributor.coauthorErdinc, Oguz
dc.contributor.coauthorSaygi, Serap
dc.contributor.coauthorTezer-Filik, Irsel
dc.contributor.coauthorApaydin-Dogan, Ebru
dc.contributor.coauthorAkyol, Ali
dc.contributor.coauthorKamisli, Ozden
dc.contributor.coauthorYalcin, A. Destina
dc.contributor.coauthorCakmak, Gonul
dc.contributor.coauthorErsoy, Alevtina
dc.contributor.coauthorUstun-Ozek, Sibel
dc.contributor.coauthorHalac, Gulistan
dc.contributor.coauthorKutlu, Gulnihal
dc.contributor.coauthorTantik-Pak, Aygul
dc.contributor.coauthorYucel, Sevinc P. P.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorGürses, Rabia Candan
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:31:23Z
dc.date.issued2023
dc.description.abstractObjectiveThe present study was aimed at investigating the effects of anti-seizure medications (ASMs), patient demographic characteristics, and the seizure type and frequency on the development of congenital malformations (CMs) in the infants of pregnant women with epilepsy (PWWE).MethodsPWWE followed up at the neurology outpatient clinic of 21 centers between 2014 and 2019 were included in this prospective study. The follow-up of PWWE was conducted using structured, general pregnant follow-up forms prepared by the Pregnancy and Epilepsy Study Committee. The newborns were examined by a neonatologist after delivery and at 1 and 3 months postpartum.ResultsOf the infants of 759 PWWE, 7.2% had CMs, with 5.6% having major CMs. Polytherapy, monotherapy, and no medications were received by 168 (22.1%), 548 (72.2 %), and 43 (5.7 %) patients, respectively. CMs were detected at an incidence of 2.3% in infants of PWWE who did not receive medication, 5.7% in infants of PWWE who received monotherapy, and 13.7% in infants of PWWE who received polytherapy. The risk of malformation was 2.31-fold (95% confidence interval (CI): 1.48-4.61, p < .001) higher in infants of PWWE who received polytherapy. Levetiracetam was the most frequently used seizure medication as monotherapy, with the highest incidence of CMs occurring with valproic acid (VPA) use (8.5%) and the lowest with lamotrigine use (2.1%). The incidence of CMs was 5% at a carbamazepine dose <700 mg, 10% at a carbamazepine dose & GE;700 mg, 5.5% at a VPA dose <750 mg, and 14.8% at a VPA dose =750 mg. Thus the risk of malformation increased 2.33 times (p = .041) in infants of PWWE receiving high-dose ASMs.SignificanceBirth outcomes of PWWE receiving and not receiving ASMs were evaluated. The risk of CMs occurrence was higher, particularly in infants of PWWE using VPA and receiving polytherapy. The incidence of CMs was found to be lower in infants of PWWE receiving lamotrigine.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue9
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume64
dc.identifier.doi10.1111/epi.17692
dc.identifier.eissn1528-1167
dc.identifier.issn0013-9580
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85165272909
dc.identifier.urihttps://doi.org/10.1111/epi.17692
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26229
dc.identifier.wos1029932900001
dc.keywordsAnti-seizure medications
dc.keywordsCongenital malformation
dc.keywordsPregnant women with epilepsy
dc.keywordsTeratogenicity
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofEpilepsia
dc.subjectSurgery
dc.subjectMedicine
dc.titleBirth outcomes in pregnant women with epilepsy: A Nationwide multicenter study from Türkiye
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorGürses, Rabia Candan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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