Publication:
Rotational thromboelastometry reveals distinct coagulation profiles for patients with COVID-19 depending on disease severity

dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorGönenli, Mehmet Gökhan
dc.contributor.kuauthorKomesli, Zeynep
dc.contributor.kuauthorİncir, Said
dc.contributor.kuauthorYalçın, Özlem
dc.contributor.kuauthorAkay, Olga Meltem
dc.contributor.kuprofileTeaching Faculty
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.yokid350445
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokid218440
dc.contributor.yokid170966
dc.date.accessioned2024-11-09T13:44:45Z
dc.date.issued2021
dc.description.abstractIdentifying a hypercoagulable state in patients with COVID-19 may help identify those at risk for virus–induced thromboembolic events and improve clinical outcomes using personalized therapeutic approaches. Herein, we aimed to perform a global assessment of the patients’ hemostatic system with COVID-19 using rotational thromboelastometry (ROTEM) and to describe whether patients with different disease severities present different coagulation profiles. Together with 37 healthy volunteers, a total of 65 patients were included and then classified as having mild, moderate, and severe disease depending on clinical severity. Peripheral blood samples were collected and analyzed using a ROTEM Coagulation Analyzer. Also, complete blood count and coagulation parameters including prothrombin time, activated partial thromboplastin time, fibrinogen levels, and D-dimer levels were measured at admission. EXTEM and INTEM MCF (P < 0.001) values were significantly higher and the EXTEM CFT (P = 0.002) value was significantly lower in patients with COVID-19 when compared with controls. In particular, patients with the severe disease showed a significant decrease in CFT (P < 0.001) and an increase in MCF (P < 0.001) in both INTEM and EXTEM assays compared with patients with the non-severe disease. Correlation analysis revealed significant correlations between ROTEM parameters and other coagulation parameters. There were significant positive correlations between fibrinogen, D-dimer, platelet count, and MCF in both EXTEM and INTEM assays. Our data demonstrate thromboelastographic signs of hypercoagulability in patients with COVID-19, which is more pronounced in patients with increased disease severity. Therefore, ROTEM analysis can classify subsets of patients with COVID-19 at significant thrombotic risk and assist in clinical decisions.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume27
dc.formatpdf
dc.identifier.doi10.1177/10760296211027653
dc.identifier.eissn1938-2723
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03070
dc.identifier.issn1076-0296
dc.identifier.linkhttps://doi.org/10.1177/10760296211027653
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85109043288
dc.identifier.urihttps://hdl.handle.net/20.500.14288/3531
dc.identifier.wos688048600001
dc.keywordsCoagulopathy
dc.keywordsCOVID-19
dc.keywordsThromboelastometry
dc.languageEnglish
dc.publisherSage
dc.relation.grantnoNA
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9728
dc.sourceClinical and Applied Thrombosis/Hemostasis
dc.subjectHematology
dc.subjectPeripheral vascular disease
dc.subjectCardiovascular system
dc.subjectCardiology
dc.titleRotational thromboelastometry reveals distinct coagulation profiles for patients with COVID-19 depending on disease severity
dc.typeJournal Article
dspace.entity.typePublication
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local.contributor.authoridN/A
local.contributor.authoridN/A
local.contributor.authorid0000-0001-5547-6653
local.contributor.authorid0000-0002-6759-1939
local.contributor.kuauthorGönenli, Mehmet Gökhan
local.contributor.kuauthorKomesli, Zeynep
local.contributor.kuauthorİncir, Said
local.contributor.kuauthorYalçın, Özlem
local.contributor.kuauthorAkay, Olga Meltem
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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