Publication: Application of the numerical fractionation approach to the design of biofunctional PEG hydrogel membranes
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Abstract
A mathematical model is described for surface-initiated photopolymerization of PEG-DA forming crosslinked biofunctional PEG hydrogel membranes based on the NF technique. The model includes an additional monomer with biological functionality, which is a common experimental strategy for the design of ECM mimics in tissue engineering in order to direct signaling pathways, and considers concentration-dependent VP propagation and reaction diffusion termination. The influence of these features on the crosslink density of the soluble and gel phases, the progression through gelation, sol/gel fraction, and molecular weight distribution of biofunctional PEG hydrogel are studied using the NF model. This model may be useful for specific applications of tissue engineering.
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Wiley-V C H Verlag Gmbh
Subject
Engineering, Chemical engineering, Polymer science
Citation
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Source
Macromolecular Reaction Engineering
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Edition
DOI
10.1002/mren.201100073