Publication:
Metabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis

dc.contributor.coauthorYilmaz, Bulent
dc.contributor.coauthorVellanki, Priyathama
dc.contributor.coauthorYildiz, Bulent Okan
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAta, Mustafa Barış
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:46:46Z
dc.date.issued2018
dc.description.abstractObjective: To provide an evidence-based assessment of metabolic syndrome, hypertension, and hyperlipidemia in first-degree relatives of women with polycystic ovary syndrome (PCOS). Design: Systematic review and meta-analysis. Setting: Not applicable. Patient(s): Mothers, fathers, sisters, and brothers of women with and without PCOS. Intervention(s): An electronic-based search with the use of PubMed from 1960 to June 2015 and cross-checked references of relevant articles. Main Outcome Measure(s): Metabolic syndrome, hypertension and dyslipidemia, and surrogate markers, including systolic blood pressure (BP), diastolic BP, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. Result(s): Fourteen of 3,346 studies were included in the meta-analysis. Prevalence of the following was significantly increased in relatives of women with PCOS: metabolic syndrome (risk ratio [RR] 1.78 [95% confidence interval 1.37, 2.30] in mothers, 1.43 [1.12, 1.81] in fathers, and 1.50 [1.12, 2.00] in sisters), hypertension (RR 1.93 [1.58, 2.35] in fathers, 2.92 [1.92, 4.45] in sisters), and dyslipidemia (RR 3.86 [2.54, 5.85] in brothers and 1.29 [1.11, 1.50] in fathers). Moreover, systolic BP (mothers, sisters, and brothers), total cholesterol (mothers and sisters), low-density lipoprotein cholesterol (sisters), and triglycerides (mothers and sisters) were significantly higher in first-degree relatives of PCOS probands than in controls. Conclusion(s): Our results show evidence of clustering for metabolic syndrome, hypertension, and dyslipidemia in mothers, fathers, sisters, and brothers of women with PCOS.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipMerck
dc.description.sponsorshipBoehringer Ingelheim P.V. has received consulting fees from Merck and Boehringer Ingelheim. B.Y. has nothing to disclose. B.A. has nothing to disclose. B.O.Y. has nothing to disclose.
dc.description.volume109
dc.identifier.doi10.1016/j.fertnstert.2017.10.018
dc.identifier.eissn1556-5653
dc.identifier.issn0015-0282
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85040363655
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2017.10.018
dc.identifier.urihttps://hdl.handle.net/20.500.14288/14009
dc.identifier.wos424939300032
dc.keywordsDyslipidemia
dc.keywordsFirst-degree relatives
dc.keywordsHypertension
dc.keywordsMetabolic syndrome
dc.keywordsPolycystic ovary syndrome impaired glucose-tolerance
dc.keywordsFirst-degree relatives
dc.keywordsII diabetes-mellitus
dc.keywords1st degree relatives
dc.keywordsInsulin-resistance
dc.keywords1st-degree relatives
dc.keywordsCardiovascular Risk
dc.keywordsFamily-history
dc.keywordsSyndrome pcos
dc.keywordsDehydroepiandrosterone-sulfate
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.ispartofFertility and Sterility
dc.subjectObstetrics
dc.subjectGynecology
dc.subjectReproductive biology
dc.titleMetabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorAta, Mustafa Barış
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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