Publication: Metabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis
dc.contributor.coauthor | Yilmaz, Bulent | |
dc.contributor.coauthor | Vellanki, Priyathama | |
dc.contributor.coauthor | Yildiz, Bulent Okan | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Ata, Mustafa Barış | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T23:46:46Z | |
dc.date.issued | 2018 | |
dc.description.abstract | Objective: To provide an evidence-based assessment of metabolic syndrome, hypertension, and hyperlipidemia in first-degree relatives of women with polycystic ovary syndrome (PCOS). Design: Systematic review and meta-analysis. Setting: Not applicable. Patient(s): Mothers, fathers, sisters, and brothers of women with and without PCOS. Intervention(s): An electronic-based search with the use of PubMed from 1960 to June 2015 and cross-checked references of relevant articles. Main Outcome Measure(s): Metabolic syndrome, hypertension and dyslipidemia, and surrogate markers, including systolic blood pressure (BP), diastolic BP, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. Result(s): Fourteen of 3,346 studies were included in the meta-analysis. Prevalence of the following was significantly increased in relatives of women with PCOS: metabolic syndrome (risk ratio [RR] 1.78 [95% confidence interval 1.37, 2.30] in mothers, 1.43 [1.12, 1.81] in fathers, and 1.50 [1.12, 2.00] in sisters), hypertension (RR 1.93 [1.58, 2.35] in fathers, 2.92 [1.92, 4.45] in sisters), and dyslipidemia (RR 3.86 [2.54, 5.85] in brothers and 1.29 [1.11, 1.50] in fathers). Moreover, systolic BP (mothers, sisters, and brothers), total cholesterol (mothers and sisters), low-density lipoprotein cholesterol (sisters), and triglycerides (mothers and sisters) were significantly higher in first-degree relatives of PCOS probands than in controls. Conclusion(s): Our results show evidence of clustering for metabolic syndrome, hypertension, and dyslipidemia in mothers, fathers, sisters, and brothers of women with PCOS. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 2 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | Merck | |
dc.description.sponsorship | Boehringer Ingelheim P.V. has received consulting fees from Merck and Boehringer Ingelheim. B.Y. has nothing to disclose. B.A. has nothing to disclose. B.O.Y. has nothing to disclose. | |
dc.description.volume | 109 | |
dc.identifier.doi | 10.1016/j.fertnstert.2017.10.018 | |
dc.identifier.eissn | 1556-5653 | |
dc.identifier.issn | 0015-0282 | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85040363655 | |
dc.identifier.uri | https://doi.org/10.1016/j.fertnstert.2017.10.018 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/14009 | |
dc.identifier.wos | 424939300032 | |
dc.keywords | Dyslipidemia | |
dc.keywords | First-degree relatives | |
dc.keywords | Hypertension | |
dc.keywords | Metabolic syndrome | |
dc.keywords | Polycystic ovary syndrome impaired glucose-tolerance | |
dc.keywords | First-degree relatives | |
dc.keywords | II diabetes-mellitus | |
dc.keywords | 1st degree relatives | |
dc.keywords | Insulin-resistance | |
dc.keywords | 1st-degree relatives | |
dc.keywords | Cardiovascular Risk | |
dc.keywords | Family-history | |
dc.keywords | Syndrome pcos | |
dc.keywords | Dehydroepiandrosterone-sulfate | |
dc.language.iso | eng | |
dc.publisher | Elsevier Science Inc | |
dc.relation.ispartof | Fertility and Sterility | |
dc.subject | Obstetrics | |
dc.subject | Gynecology | |
dc.subject | Reproductive biology | |
dc.title | Metabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis | |
dc.type | Review | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Ata, Mustafa Barış | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
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relation.isOrgUnitOfPublication.latestForDiscovery | d02929e1-2a70-44f0-ae17-7819f587bedd | |
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