Publication:
Current practice with operative hysteroscopy for fertility preservation in endometrial cancer and endometrial premalignancies

dc.contributor.coauthorKacperczyk-Bartnik, Joanna
dc.contributor.coauthorBizzarri, Nicolo
dc.contributor.coauthorKahramanoğlu, İlker
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBilir, Esra
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:36:25Z
dc.date.issued2024
dc.description.abstractPurposeThe primary aim was to analyze the current practices on the use of operative hysteroscopy for preserving fertility in patients diagnosed with endometrial cancer and premalignancies. Our secondary objectives included investigating medical therapy and analyzing reported pregnancy-related outcomes subsequent to fertility preservation procedures.MethodsWe performed a semi-systematic literature review on PubMed, employing pertinent terms related to hysteroscopy, fertility preservation, and endometrial cancer and premalignancies. Patients undergoing operative hysteroscopy with or without following medical treatment were included. We adhered to the PRISMA 2020 statement and utilized Covidence software to manage our systematic review. We performed a pooled analysis on various outcomes.ResultsOur final analysis included 15 studies evaluating 458 patients, where 238 (52.0%) were diagnosed with endometrial cancer, and 220 (48.0%) had endometrial premalignancies. With 146 pregnancies in our study, the overall pregnancy rate was 31.9%. Among these, 97 resulted in live births, accounting for 66.4% of the reported pregnancies. In terms of medical treatment, various forms of progestins were reported. Complications or adverse effects related to operative hysteroscopy were not reported in more than half of the studies. Among those studies that did report them, no complications nor adverse effects were documented. After hysteroscopic resection, complete response to medical treatment has been reported in 65.5% of the overall cases.ConclusionOur review sheds light on the contemporary landscape of operative hysteroscopy for fertility preservation in endometrial cancer and premalignancies. Future studies should include the integration of molecular classification into fertility-preserving management of endometrial malignancies to offer a more personalized and precise strategy.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue6
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume309
dc.identifier.doi10.1007/s00404-024-07463-9
dc.identifier.eissn1432-0711
dc.identifier.issn0932-0067
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85187928472
dc.identifier.urihttps://doi.org/10.1007/s00404-024-07463-9
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22053
dc.identifier.wos1185990700002
dc.keywordsAtypical endometrial hyperplasia
dc.keywordsEndometrial cancer
dc.keywordsOperative hysteroscopy
dc.keywordsFertility preservation
dc.keywordsPregnancy
dc.language.isoeng
dc.publisherSpringer Heidelberg
dc.relation.ispartofArchives of Gynecology and Obstetrics
dc.subjectObstetrics
dc.subjectGynecology
dc.titleCurrent practice with operative hysteroscopy for fertility preservation in endometrial cancer and endometrial premalignancies
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorBilir, Esra
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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