Publication:
Magnetic iron-based nanoparticles encapsulated in graphene/reduced graphene oxide: synthesis, functionalization and cytotoxicity tests

dc.contributor.coauthorMoral, Sencer
dc.contributor.coauthorSari, Seyma
dc.contributor.coauthorTurk, Miray
dc.contributor.coauthorKahveci, Muhammet U.
dc.contributor.coauthorDoganay, Gizem Dinler
dc.contributor.coauthorAgaogullari, Duygu
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.kuauthorAzmoudeh, Aysa
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.date.accessioned2025-03-06T20:59:21Z
dc.date.issued2024
dc.description.abstractNanomaterials for suitable particle sizes, shapes, surface properties, biocompatibility, magnetic properties, and chemical stability are candidates for biomedical applications. Among these nanomaterials, iron-based ones are highly interested in their morphological and magnetic properties for potential utilizations in biomedicine. However, iron-based nanoparticles lose their chemical stability in body fluids because of their oxide formations and transformations. Their use in biomedical applications, especially in imaging, may be less effective if they are oxidized and have lower magnetization values. Thus, the idea of coating them with a protective layer has recently emerged to prevent magnetic nanoparticles from degrading in human fluids and losing their magnetic properties. However, the biological effects of these coated nanoparticles on human cells are poorly understood. In this paper, the synthesis of multilayer graphene (MLG) encapsulated iron-based nanoparticles was investigated by solvothermal and chemical vapor deposition (CVD) methods followed by purification. Subsequently, their surface modification was conducted with pyrene end-functional POEGMA obtained by atom transfer radical polymerization (ATRP). Cytotoxicities of synthesized nanoparticles were evaluated in MCF7 cell lines, which is a commonly used model for breast cancer research. We also compare the results with those obtained from bare iron oxide nanoparticles (IONPs) and iron oxides that were embedded in reduced graphene oxide (rGO) or partially coated with it. We aim to evaluate the safety and efficiency of these nanoparticles and increase their chemical stability as a multifunctional nano platform for cancer diagnosis and treatment. Characterization techniques such as XRD, XPS, SEM, TEM, DTA/TG, DLS, zeta potential, BET, NMR, FTIR, and VSM were performed on the nanoparticles. Cytotoxicity assessments on MCF-7 cell lines indicated the potential of these graphene-based magnetic nanoparticles for biomedical applications, particularly drug delivery, due to their small size, soft ferromagnetic properties, high chemical stability, and cytocompatibility at concentrations below 500 mu g/mL over short incubation times.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Department of Istanbul Technical University, with the project number of MDA-2022-43611 (ITU BAP/DAP Project) . We express our gratitude to Asst. Prof. Dr. Murat Kuscu from Koc University for his invaluable support in all characterization analyses, and Dr. Sedat Kurnaz from Kastamonu University for conducting the VSM analyses. We also extend our thanks to KUYTAM for their assistance with XPS and BET analyses and to KUBAM for their help with DTA/TG analyses. Additionally, we appreciate the help from Koc University Nanofabrication and Nano- characterization Center (n2star) for the TEM analysis.
dc.identifier.doi10.1016/j.jsamd.2024.100776
dc.identifier.eissn2468-2179
dc.identifier.grantnoScientific Research Projects Department of Istanbul Technical University [MDA-2022-43611]
dc.identifier.issn2468-2284
dc.identifier.issue4
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85204231297
dc.identifier.urihttps://doi.org/10.1016/j.jsamd.2024.100776
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27669
dc.identifier.volume9
dc.identifier.wos1319442100001
dc.keywordsMagnetic nanoparticles (MNPs)
dc.keywordsMultilayer graphene (MLG)
dc.keywordsReduced graphene oxide (rGO)
dc.keywordsFunctionalization
dc.keywordsMagnetic/thermal properties
dc.keywordsCytotoxicity
dc.language.isoeng
dc.publisherVIETNAM NATL UNIV
dc.relation.ispartofJournal of Science: Advanced Materials and Devices
dc.subjectNanoscience and nanotechnology
dc.subjectMaterials science, multidisciplinary
dc.titleMagnetic iron-based nanoparticles encapsulated in graphene/reduced graphene oxide: synthesis, functionalization and cytotoxicity tests
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAzmoudeh, Aysa
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit2Graduate School of Sciences and Engineering
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relation.isParentOrgUnitOfPublication434c9663-2b11-4e66-9399-c863e2ebae43
relation.isParentOrgUnitOfPublication.latestForDiscovery434c9663-2b11-4e66-9399-c863e2ebae43

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