Publication:
Which is more predictive ovarian sensitivity marker if there is discordance between serum anti-Müllerian hormone levels and antral follicle count? a retrospective analysis

dc.contributor.coauthorAslan, Kiper
dc.contributor.coauthorKasapoğlu, Işıl
dc.contributor.coauthorÇakır, Cihan
dc.contributor.coauthorKoç, Meltem
dc.contributor.coauthorÇelenk, Murat Deniz
dc.contributor.coauthorAvcı, Berrin
dc.contributor.coauthorUncu, Gürkan
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAta, Mustafa Barış
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:59:10Z
dc.date.issued2022
dc.description.abstractThis retrospective study aims to determine the more predictive ovarian reserve marker when there is discordance between anti-Mullerian hormone (AMH) and antral follicle count (AFC) in patients with diminished ovarian reserve (DOR). Patients who underwent ICSI because of DOR were divided into three groups. Group 1: patients with low AMH (<1.1 ng/ml) and AFC (n < 7), group 2: patients with low AMH (<1.1 ng/ml) and normal AFC (n >= 7) and group 3: patients with normal AMH (>= 1.1 ng/dl) and low AFC (n < 7). Demographic values, follicle output rate (FORT) score and follicle to oocyte index (FOI) score of the groups were compared. Totally, 662 cycles were enrolled in the study. There were 418 cycles in group 1, 167 cycles in group 2 and 77 cycles in group 3. As the primary result, FORT and FOI scores were higher in group 3 than the other two groups. Median FORT Score with quartiles: group 1: 100 (66-150), group 2: 71 (57-100), group 3: 136 (96-200), p<.01 - median FOI score with quartiles: group 1: 83 (50-140), group 2: 71 (40-100), group 3: 116 (66-216), p<.01. In conclusion, serum AMH level has more predictive value for stimulation success if there is discordance with AFC.Impact Statement What is already known on this subject? Female age, serum Anti-Mullerian Hormone (AMH) levels, and antral follicle count (AFC) are commonly used to assess ovarian reserve and predict response to ovarian stimulation. AMH and AFC are both positively correlated with ovarian reserve. What do the results of this study add? If there is discordance between AFC and AMH in patients with diminished ovarian reserve (DOR), the ovarian response is better in patients with high AMH and low AFC than the patients with low AMH and high AFC. What are the implications of these findings for clinical practice and/or further research? It is important to assess both AFC and AMH before controlled ovarian hyperstimulation, to predict ovarian response in DOR patients, rather than assessing AFC or AMH alone.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue5
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume42
dc.identifier.doi10.1080/01443615.2021.2003309
dc.identifier.eissn1364-6893
dc.identifier.issn0144-3615
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85122699611
dc.identifier.urihttps://doi.org/10.1080/01443615.2021.2003309
dc.identifier.urihttps://hdl.handle.net/20.500.14288/15572
dc.identifier.wos740581600001
dc.keywordsAnti-mullerian hormone
dc.keywordsAntral follicle count
dc.keywordsOvarian sensitivity
dc.keywordsInfertility
dc.keywordsIn vitro fertilisation
dc.keywordsFollicle to oocyte index
dc.keywordsFollicle output rate
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Obstetrics and Gynaecology
dc.subjectObstetrics and gynecology
dc.titleWhich is more predictive ovarian sensitivity marker if there is discordance between serum anti-Müllerian hormone levels and antral follicle count? a retrospective analysis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAta, Mustafa Barış
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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