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Adipose tissue-derived mesenchymal stem cells rescue spermatogenesis and alleviate testicular damage in a rat model of chemotherapy-induced infertility

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dc.contributor.coauthorDowidar, Yousry A.
dc.contributor.coauthorMousbah, Ahmed M
dc.contributor.coauthorMohammed, Waleed S.
dc.contributor.coauthorAbdallah, Ahmed N.
dc.contributor.departmentKUISCID (Koç University İşbank Center for Infectious Diseases)
dc.contributor.kuauthorAllayeh, Abdou
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2026-08-14T11:20:11Z
dc.date.issued2024
dc.description.abstractStem cell therapy is one of the most promising fields of biomedical research, as enthusiasm for its applications and effectiveness have been proven in different therapeutic approaches.Therefore, we aimed to appraise the therapeutic role of adipose tissue-derived mesenchymal stem cells (AT-MSCs) in mitigating cyclophosphamide (CTX)-induced infertility in a rat model.The study included three experimental groups: control, CTX, and stem cell treatment groups.Testes were collected for histopathological analysis and gene expression assessment of protamine, prohibitin, and StAR genes.The results showed that cyclophosphamide impaired spermatogenesis and caused testicular damage.However, the transplantation of AT-MSCs facilitated the restoration of the seminiferous epithelium and enhanced the regeneration of spermatogenesis.The expression of protamine, prohibitin, and StAR genes was upregulated in the AT-MSCs group compared to the CTX group.This study provides further evidence for the relationship between the expression of protamine and prohibitin genes and male infertility.In conclusion, AT-MSCs were able to recover the spermatogenesis process and regenerate the damaged testicular elements in cyclophosphamide-treated rats.
dc.description.harvestedfromManual
dc.description.indexedbyScopus
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.description.versionPublished Version
dc.identifier.ScopusPercentile90
dc.identifier.ScopusQuartileQ1
dc.identifier.WoSPercentileN/A
dc.identifier.WoSQuartileN/A
dc.identifier.doi10.47278/journal.ijvs/2024.249
dc.identifier.eissn2305-4360
dc.identifier.embargoN/A
dc.identifier.endpage309
dc.identifier.issn2304-3075
dc.identifier.issue2
dc.identifier.scopus2-s2.0-105005711114
dc.identifier.startpage302
dc.identifier.urihttp://doi.org/10.47278/journal.ijvs/2024.249
dc.identifier.urihttps://hdl.handle.net/20.500.14288/34292
dc.identifier.volume14
dc.keywordsCyclophosphamide
dc.keywordsGene expression
dc.keywordsInfertility
dc.keywordsSpermatogenesis
dc.keywordsStem cells
dc.languageeng
dc.publisherUnique Scientific Publishers
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofInternational Journal of Veterinary Science
dc.relation.openaccessN/A
dc.rightsN/A
dc.rights.uriN/A
dc.subjectHealth sciences
dc.subjectMedicine
dc.titleAdipose tissue-derived mesenchymal stem cells rescue spermatogenesis and alleviate testicular damage in a rat model of chemotherapy-induced infertility
dc.typeJournal Article
dspace.entity.typePublication
relation.isOrgUnitOfPublication09525e58-d4ea-4461-b2ec-f131e54c0771
relation.isOrgUnitOfPublication.latestForDiscovery09525e58-d4ea-4461-b2ec-f131e54c0771
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