Publication:
Clinical predictors of Alzheimer's disease-like brain atrophy in individuals with memory complaints

dc.contributor.coauthorKarakasli AA, Karacam Dogan M, Cap D, Karaosmanoglu A, Karahan S, Zorlu N, Saka E, Ayhan Y.
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.kuauthorÖzkan, Esra
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2024-12-29T09:36:41Z
dc.date.issued2024
dc.description.abstractObjectivesThe definition and assessment methods for subjective cognitive decline (SCD) vary among studies. We aimed to investigate which features or assessment methods of SCD best predict Alzheimer's disease (AD)-related structural atrophy patterns.MethodsWe assessed 104 individuals aged 55+ with memory complaints but normal cognitive screening. Our research questions were as follows: To improve the prediction of AD related morphological changes, (1) Would the use of a standardized cognitive screening scale be beneficial? (2) Is conducting a thorough neuropsychological evaluation necessary instead of relying solely on cognitive screening tests? (3) Should we apply SCD-plus research criteria, and if so, which criterion would be the most effective? (4) Is it necessary to consider medical and psychiatric comorbidities, vitamin deficiencies, vascular burden on MRI, and family history? We utilized Freesurfer to analyze cortical thickness and regional brain volume meta-scores linked to AD or predicting its development. We employed multiple linear regression models for each variable, with morphology as the dependent variable.ResultsAD-like morphology was associated with subjective complaints in males, individuals with advanced age, and higher education. Later age of onset for complaints, complaints specifically related to memory, excessive deep white matter vascular lesions, and using medications that have negative implications for cognitive health (according to the Beers criteria) were predictive of AD-related morphology. The subjective cognitive memory questionnaire scores were found to be a better predictor of reduced volumes than a single-question assessment. It is important to note that not all SCD-plus criteria were evaluated in this study, particularly the APOE genotype, amyloid, and tau status, due to resource limitations.ConclusionsThe detection of AD-related structural changes is impacted by demographics and assessment methods. Standardizing SCD assessment methods can enhance predictive accuracy.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue5
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume14
dc.identifier.doi10.1002/brb3.3506
dc.identifier.issn2162-3279
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85191776884
dc.identifier.urihttps://doi.org/10.1002/brb3.3506
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22128
dc.identifier.wos1209790000001
dc.keywordsAlzheimer
dc.keywordsCortical thickness
dc.keywordsImaging biomarkers
dc.keywordsSubjective cognitive decline
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofBrain Behavior
dc.subjectMedicine
dc.titleClinical predictors of Alzheimer's disease-like brain atrophy in individuals with memory complaints
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorÖzkan, Esra
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
relation.isOrgUnitOfPublication91bbe15d-017f-446b-b102-ce755523d939
relation.isOrgUnitOfPublication.latestForDiscovery91bbe15d-017f-446b-b102-ce755523d939
relation.isParentOrgUnitOfPublicationd437580f-9309-4ecb-864a-4af58309d287
relation.isParentOrgUnitOfPublication.latestForDiscoveryd437580f-9309-4ecb-864a-4af58309d287

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
IR04864.pdf
Size:
696.48 KB
Format:
Adobe Portable Document Format