Publication: Hematopoietic growth factor family for stroke drug development
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Co-Authors
Digiçaylıoğlu, Murat
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Embargo Status
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Abstract
Hematopoietic growth factors (HGFs) are a family of cytokines that play important roles in the survival, proliferation, and differentiation of hematopoietic progenitors, as well as in the functional activation of mature cells. However, there is a growing body evidences have suggested that HGFs have important non-hematopoietic functions in the central nervous system. Preclinical studies have demonstrated significant benefits from the use of these cytokines in the acute and chronic treatment of various neurological disorders. Unfortunately, the efficacy of these candidate neuroprotectants in animal experiments does not reliably predict efficacy in stroke patients. This chapter presents a broad overview of data from preclinical neuroprotection and clinical trial studies.
Source
Publisher
Springer
Subject
Clinical neuropsychology, neurosciences
Citation
Has Part
Source
Translational Stroke Research: From Target Selection To Clinical Trials
Book Series Title
Edition
DOI
10.1007/978-1-4419-9530-8_12