Publication:
The influence of plastic deformation mechanisms on the adhesion behavior and collagen formation in osteoblast cells

dc.contributor.coauthorMonte F.
dc.contributor.coauthorAwad, Kamal R.
dc.contributor.coauthorAswath, Pranesh B.
dc.contributor.coauthorVaranasi, Venu G.
dc.contributor.departmentDepartment of Mechanical Engineering
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.kuauthorCanadinç, Demircan
dc.contributor.kuauthorUzer, Benay
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.date.accessioned2024-11-09T23:05:21Z
dc.date.issued2018
dc.description.abstractIn many of biomedical applications, the implant might get in direct contact with the bone tissue where the osteogenesis needs to be stimulated. If osteoblasts can not successfully attach on the implant surface, the bone might resorb and implant can fail. In the current study MC3T3 cells were cultured on the 316L stainless steel samples which were deformed up to four different strain levels (5, 15, 25 and 35%) to activate plastic deformation mechanisms (slip and twinning) in different volume fractions. Scanning electron microscopy (SEM) images showed that cells adhered and spread significantly on the 25 and 35% deformed samples owing to the greater surface roughness and energy provided by the increased density of micro-deformation mechanisms which promoted the formation of focal contacts. In addition, significant amount of collagen formation was observed on the sample deformed up to 25% of strain which can be due to the ideal match of the surface roughness and collagen molecules. Overall these results show that material’s microstructure can be manipulated through plastic deformation mechanisms in order to enhance the cell response and collagen deposition. As a result long lasting implants could be obtained which would eliminate additional surgical interventions and provide a successful treatment.
dc.description.indexedbyScopus
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volumePart F12
dc.identifier.doi10.1007/978-3-319-72526-0_27
dc.identifier.isbn9783-3197-2525-3
dc.identifier.issn2367-1181
dc.identifier.scopus2-s2.0-85044462985
dc.identifier.urihttps://doi.org/10.1007/978-3-319-72526-0_27
dc.identifier.urihttps://hdl.handle.net/20.500.14288/8785
dc.keywordsCell adhesion
dc.keywordsCollagen formation
dc.keywordsMicro-deformation mechanisms
dc.keywordsOsteoblast
dc.keywordsPlastic deformation
dc.keywordsSlip
dc.keywordsTwinning Bone
dc.keywordsCell adhesion
dc.keywordsCollagen
dc.keywordsImplants (surgical)
dc.keywordsMedical applications
dc.keywordsOsteoblasts
dc.keywordsPlastic deformation
dc.keywordsScanning electron microscopy
dc.keywordsTwinning
dc.keywords316 L stainless steel
dc.keywordsBiomedical applications
dc.keywordsCollagen formation
dc.keywordsMicro deformation mechanism
dc.keywordsPlastic deformation mechanisms
dc.keywordsScanning electron microscopy image
dc.keywordsSlip
dc.keywordsSurgical interventions
dc.keywordsSurface roughness
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofMinerals, Metals and Materials Series
dc.subjectMechanical engineering
dc.titleThe influence of plastic deformation mechanisms on the adhesion behavior and collagen formation in osteoblast cells
dc.typeConference Proceeding
dspace.entity.typePublication
local.contributor.kuauthorUzer, Benay
local.contributor.kuauthorCanadinç, Demircan
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1College of Engineering
local.publication.orgunit2Department of Mechanical Engineering
local.publication.orgunit2Graduate School of Sciences and Engineering
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