Publication:
Integrating mitoepigenetics into research in mood disorders: a state-of-the-art review

dc.contributor.coauthorArat-Çelik, Hidayet Ece
dc.contributor.kuauthorCeylan, Deniz
dc.contributor.kuauthorAkşahin, İzel Cemre
dc.contributor.researchcenterKoç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM)
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteGraduate School of Health Sciences
dc.date.accessioned2024-12-29T09:37:36Z
dc.date.issued2024
dc.description.abstractMood disorders, including major depressive disorder and bipolar disorder, are highly prevalent and stand among the leading causes of disability. Despite the largely elusive nature of the molecular mechanisms underpinning these disorders, two pivotal contributors-mitochondrial dysfunctions and epigenetic alterations-have emerged as significant players in their pathogenesis. This state-of-the-art review aims to present existing data on epigenetic alterations in the mitochondrial genome in mood disorders, laying the groundwork for future research into their pathogenesis. Associations between abnormalities in mitochondrial function and mood disorders have been observed, with evidence pointing to notable changes in mitochondrial DNA (mtDNA). These changes encompass variations in copy number and oxidative damage. However, information on additional epigenetic alterations in the mitochondrial genome remains limited. Recent studies have delved into alterations in mtDNA and regulations in the mitochondrial genome, giving rise to the burgeoning field of mitochondrial epigenetics. Mitochondrial epigenetics encompasses three main categories of modifications: mtDNA methylation/hydroxymethylation, modifications of mitochondrial nucleoids, and mitochondrial RNA alterations. The epigenetic modulation of mitochondrial nucleoids, lacking histones, may impact mtDNA function. Additionally, mitochondrial RNAs, including non-coding RNAs, present a complex landscape influencing interactions between the mitochondria and the nucleus. The exploration of mitochondrial epigenetics offers valuable perspectives on how these alterations impact neurodegenerative diseases, presenting an intriguing avenue for research on mood disorders. Investigations into post-translational modifications and the role of mitochondrial non-coding RNAs hold promise to unravel the dynamics of mitoepigenetics in mood disorders, providing crucial insights for future therapeutic interventions.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessgold, Green Published
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorsThe author(s) declare financial support was received for the research, authorship, and/or publication of this article. This review article has been conducted within the scope of the TUBITAK 1001 project with the number 122Z771.Additionally, support from Koc University has been obtained for its publication.
dc.description.volume15
dc.identifier.doi10.3389/fphys.2024.1338544
dc.identifier.eissn1664-042X
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85185945610
dc.identifier.urihttps://doi.org/10.3389/fphys.2024.1338544
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22409
dc.identifier.wos1169958200001
dc.keywordsMood disorders
dc.keywordsBipolar disorder
dc.keywordsMajor depression
dc.keywordsEpigenetics
dc.keywordsMitochondrial dysfunction
dc.keywordsMitoepigenetics
dc.languageen
dc.publisherFrontiers Media Sa
dc.relation.grantnoTUBITAK [122Z771]
dc.relation.grantnoKoc University
dc.sourceFrontiers in Physiology
dc.subjectPhysiology
dc.titleIntegrating mitoepigenetics into research in mood disorders: a state-of-the-art review
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorCeylan, Deniz
local.contributor.kuauthorAkşahin, İzel Cemre

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