Publication:
Mathematical model for microencapsulation of pancreatic islets within a biofunctional PEG hydrogel

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dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.facultymemberYes
dc.contributor.kuauthorKızılel, Seda
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.date.accessioned2024-11-09T23:51:41Z
dc.date.issued2010
dc.description.abstractThe results of a mathematical model for surface-initiated polymerization of biofunctional PEG-based hydrogels to predict gel properties prior to synthesis is reported. The mathematical model developed in this study describes microencapsulation of islets within an insulinotropic peptide (GLP-1) functionalized PEG hydrogels. Experimental measurements of the thickness and swelling of GLP-1 functionalized hydrogel membranes compare well with the model. The model is capable of predicting the crosslink density, thickness, and the level of GLP-1 incorporation within the membrane. This study demonstrates the possibility of modulating the concentration of biological cues in highly permissive and biofunctional PEG hydrogels for optimizing engineered tissue function.
dc.description.fulltextNo
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.openaccessNO
dc.description.peerreviewstatusN/A
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipEuropean Union (EU) - Marie Curie Reintegration Grant [FP7-PEOPLE-IRG-239471]
dc.description.sponsorshipKoç University
dc.description.sponsorshipTurkish Academy of Sciences (TÜBA)
dc.description.studentonlypublicationNo
dc.description.studentpublicationNo
dc.description.versionN/A
dc.identifier.WoSQuartileQ3
dc.identifier.doi10.1002/mats.201000033
dc.identifier.eissn1521-3919
dc.identifier.embargoN/A
dc.identifier.endpage531
dc.identifier.grantnoFP7-PEOPLE-IRG-239471
dc.identifier.issn1022-1344
dc.identifier.issue8-9
dc.identifier.scopus2-s2.0-78650026344
dc.identifier.startpage514
dc.identifier.urihttps://doi.org/10.1002/mats.201000033
dc.identifier.urihttps://hdl.handle.net/20.500.14288/14756
dc.identifier.volume19
dc.identifier.wos000285704900005
dc.keywordsPEG hydrogel
dc.keywordsSurface-initiated polymerization
dc.keywordsIslet microencapsulation
dc.keywordsMathematical modeling
dc.language.isoeng
dc.publisherWiley
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofMacromolecular Theory and Simulations
dc.relation.openaccessN/A
dc.relation.projectMICROENCAPSULATION OF ISLETS WITHIN FUNCTIONALIZED PEG HYDROGEL
dc.rightsN/A
dc.subjectPolymer science
dc.titleMathematical model for microencapsulation of pancreatic islets within a biofunctional PEG hydrogel
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKızılel, Seda
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