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Mathematical model for microencapsulation of pancreatic islets within a biofunctional PEG hydrogel

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dc.contributor.coauthorN/A
dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.kuauthorKızılel, Seda
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.date.accessioned2024-11-09T23:51:41Z
dc.date.issued2010
dc.description.abstractThe results of a mathematical model for surface-initiated polymerization of biofunctional PEG-based hydrogels to predict gel properties prior to synthesis is reported. The mathematical model developed in this study describes microencapsulation of islets within an insulinotropic peptide (GLP-1) functionalized PEG hydrogels. Experimental measurements of the thickness and swelling of GLP-1 functionalized hydrogel membranes compare well with the model. The model is capable of predicting the crosslink density, thickness, and the level of GLP-1 incorporation within the membrane. This study demonstrates the possibility of modulating the concentration of biological cues in highly permissive and biofunctional PEG hydrogels for optimizing engineered tissue function.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue45177
dc.description.openaccessNO
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipMarie Curie Reintegration Grant [FP7-PEOPLE-IRG-239471]
dc.description.sponsorshipDepartment of Chemical and Biological Engineering at KOC University
dc.description.sponsorshipTUBA-L'OREAL Young Women in Science Award This work was supported in part by Marie Curie Reintegration Grant FP7-PEOPLE-IRG-239471, TUBA-L'OREAL Young Women in Science Award, and Department of Chemical and Biological Engineering at KOC University.
dc.description.volume19
dc.identifier.doi10.1002/mats.201000033
dc.identifier.issn1022-1344
dc.identifier.scopus2-s2.0-78650026344
dc.identifier.urihttps://doi.org/10.1002/mats.201000033
dc.identifier.urihttps://hdl.handle.net/20.500.14288/14756
dc.identifier.wos285704900005
dc.keywordsPoly(ethylene glycol) diacrylate
dc.keywordsSurface-initiated photopolymerization
dc.keywordsFree-radical copolymerization
dc.keywordsPropagation rate coefficients
dc.keywordsCell-matrix interactions
dc.keywordsn-vinyl pyrrolidone
dc.keywordsCross-linking
dc.keywordsIn-vitro
dc.keywordsInsulin-secretion
dc.keywordsPorcine islets
dc.language.isoeng
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofMacromolecular Theory and Simulations
dc.subjectPolymer science
dc.titleMathematical model for microencapsulation of pancreatic islets within a biofunctional PEG hydrogel
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKızılel, Seda
local.publication.orgunit1College of Engineering
local.publication.orgunit2Department of Chemical and Biological Engineering
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