Publication: Development of self-healing vanillin/PEI hydrogels for tissue engineering
dc.contributor.coauthor | Yasar, Merve | |
dc.contributor.coauthor | Oktay, Burcu | |
dc.contributor.coauthor | Aldogan, Ebru Haciosmanoglu | |
dc.contributor.coauthor | Apohan, Nilhan Kayaman | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Yöntem, Fulya Dal | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T23:11:26Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Self-healing materials recover mechanical damages to expand the lifetime of the material provided. In this study, self-healing hydrogels have been successfully prepared using a novel and simple technique. Vanillin is a natural monomer, used as a bio-based cross-linker for UV-induced bonding and Schiff-base bonding. Methacrylate-functionalized vanillin (M-VAN) is covalently integrated with the polymer matrix. While M-VAN supports polymer matrix with its vinyl group, its aldehyde functionality helps the formation of dynamic covalent imine bonds via Schiff-base formation. The hydrogel showed excellent self-healing ability overnight under physio-logical conditions without external addition. In addition, the hydrogel surface was modified by collagen and its cell viability was investigated. The prepared scaffolds showed good cell viability of 124% and 163% compared to the control sample. The developed self-healing material reveals that it has possible uses for future biomedical applications and tissue engineering studies due to the self-healing mechanism taking place under ambient conditions. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.openaccess | NO | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | The author M. Yasar acknowledges Council of Higher Education (YÖK) of Turkey for the PhD scholarship of 100/2000 program. | |
dc.description.volume | 188 | |
dc.identifier.doi | 10.1016/j.eurpolymj.2023.111933 | |
dc.identifier.eissn | 1873-1945 | |
dc.identifier.issn | 0014-3057 | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85148539590 | |
dc.identifier.uri | https://doi.org/10.1016/j.eurpolymj.2023.111933 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/9646 | |
dc.identifier.wos | 949778800001 | |
dc.keywords | Hydrogels | |
dc.keywords | Self-healing | |
dc.keywords | UV-polymerization | |
dc.keywords | Vanillin | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartof | European Polymer Journal | |
dc.subject | Polymer science | |
dc.title | Development of self-healing vanillin/PEI hydrogels for tissue engineering | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Yöntem, Fulya Dal | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
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