Publication:
Development of self-healing vanillin/PEI hydrogels for tissue engineering

dc.contributor.coauthorYasar, Merve
dc.contributor.coauthorOktay, Burcu
dc.contributor.coauthorAldogan, Ebru Haciosmanoglu
dc.contributor.coauthorApohan, Nilhan Kayaman
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorYöntem, Fulya Dal
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:11:26Z
dc.date.issued2023
dc.description.abstractSelf-healing materials recover mechanical damages to expand the lifetime of the material provided. In this study, self-healing hydrogels have been successfully prepared using a novel and simple technique. Vanillin is a natural monomer, used as a bio-based cross-linker for UV-induced bonding and Schiff-base bonding. Methacrylate-functionalized vanillin (M-VAN) is covalently integrated with the polymer matrix. While M-VAN supports polymer matrix with its vinyl group, its aldehyde functionality helps the formation of dynamic covalent imine bonds via Schiff-base formation. The hydrogel showed excellent self-healing ability overnight under physio-logical conditions without external addition. In addition, the hydrogel surface was modified by collagen and its cell viability was investigated. The prepared scaffolds showed good cell viability of 124% and 163% compared to the control sample. The developed self-healing material reveals that it has possible uses for future biomedical applications and tissue engineering studies due to the self-healing mechanism taking place under ambient conditions.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThe author M. Yasar acknowledges Council of Higher Education (YÖK) of Turkey for the PhD scholarship of 100/2000 program.
dc.description.volume188
dc.identifier.doi10.1016/j.eurpolymj.2023.111933
dc.identifier.eissn1873-1945
dc.identifier.issn0014-3057
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85148539590
dc.identifier.urihttps://doi.org/10.1016/j.eurpolymj.2023.111933
dc.identifier.urihttps://hdl.handle.net/20.500.14288/9646
dc.identifier.wos949778800001
dc.keywordsHydrogels
dc.keywordsSelf-healing
dc.keywordsUV-polymerization
dc.keywordsVanillin
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofEuropean Polymer Journal
dc.subjectPolymer science
dc.titleDevelopment of self-healing vanillin/PEI hydrogels for tissue engineering
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorYöntem, Fulya Dal
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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