Publication:
Complete response evaluation of locally advanced rectal cancer to neoadjuvant chemoradiotherapy using textural features obtained from T2 eighted imaging and ADC maps

dc.contributor.coauthorAzamat, Sena
dc.contributor.coauthorKaraman, Şule
dc.contributor.coauthorErtaş, Gökhan
dc.contributor.coauthorKülle, Cemil Burak
dc.contributor.coauthorKeskin, Metin
dc.contributor.coauthorDağoğlu, Sakin
dc.contributor.coauthorRabia Nergiz
dc.contributor.coauthorBakır, Barış
dc.contributor.coauthorOral, Ethem Nezih
dc.contributor.coauthorKartal, Merve Gülbiz
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAzamat, İbrahim Fethi
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T12:15:27Z
dc.date.issued2022
dc.description.abstractBackground: the prediction of pathological responses for locally advanced rectal cancer using magnetic resonance imaging (MRI) after neoadjuvant chemoradiotherapy (CRT) is a challenging task for radiologists, as residual tumor cells can be mistaken for fibrosis. Texture analysis of MR images has been proposed to understand the underlying pathology. Objective: this study aimed to assess the responses of lesions to CRT in patients with locally advanced rectal cancer using the first-order textural features of MRI T2-weighted imaging (T2-WI) and apparent diffusion coefficient (ADC) maps. Methods: forty-four patients with locally advanced rectal cancer (median age: 57 years) who underwent MRI before and after CRT were enrolled in this retrospective study. The first-order textural parameters of tumors on T2-WI and ADC maps were extracted. The textural features of lesions in pathologic complete responders were compared to partial responders using Student’s t- or Mann–Whitney U tests. A comparison of textural features before and after CRT for each group was performed using the Wilcoxon rank sum test. Receiver operating characteristic curves were calculated to detect the diagnostic performance of the ADC. Results: of the 44 patients evaluated, 22 (50%) were placed in a partial response group and 50% were placed in a complete response group. The ADC changes of the complete responders were statistically more significant than those of the partial responders (P = 0.002). Pathologic total response was predicted with an ADC cut-off of 1310 x 10-6 mm2/s, with a sensitivity of 72%, a specificity of 77%, and an accuracy of 78.1% after neoadjuvant CRT. The skewness of the T2-WI before and after neoadjuvant CRT showed a significant difference in the complete response group compared to the partial response group (P = 0.001 for complete responders vs. P = 0.482 for partial responders). Also, relative T2-WI signal intensity in the complete response group was statistically lower than that of the partial response group after neoadjuvant CRT (P = 0.006).Conclusion: as a result of the conversion of tumor cells to fibrosis, the skewness of the T2-WI before and after neoadjuvant CRT was statistically different in the complete response group compared to the partial response group, and the complete response group showed statistically lower relative T2-WI signal intensity than the partial response group after neoadjuvant CRT. Additionally, the ADC cut-off value of 1310 × 10-6 mm2/s could be used as a marker for a complete response along with absolute ADC value changes within this dataset.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue10
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume18
dc.identifier.doi10.2174/1573405618666220303111026
dc.identifier.eissn1875-6603
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03502
dc.identifier.issn1573-4056
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85137036765
dc.identifier.urihttps://hdl.handle.net/20.500.14288/1341
dc.identifier.wos851377100004
dc.keywordsRectum MRI
dc.keywordsComputer aided-detection
dc.keywordsTissue characterization
dc.keywordsTextural features
dc.keywordsLocally advanced rectal cancer
dc.keywordsApparent diffusion coefficient (ADC)
dc.language.isoeng
dc.publisherBentham Science
dc.relation.grantnoNA
dc.relation.ispartofCurrent Medical Imaging
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10300
dc.subjectMedicine
dc.titleComplete response evaluation of locally advanced rectal cancer to neoadjuvant chemoradiotherapy using textural features obtained from T2 eighted imaging and ADC maps
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAzamat, İbrahim Fethi
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
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