Publication: Changes in electroencephalographic characteristics and blood-brain barrier permeability in WAG/Rij rats with cortical dysplasia
dc.contributor.coauthor | Sahin, Deniz | |
dc.contributor.coauthor | Yilmaz, Canan Ugur | |
dc.contributor.coauthor | Orhan, Nurcan | |
dc.contributor.coauthor | Arican, Nadir | |
dc.contributor.coauthor | Gurses, Candan | |
dc.contributor.coauthor | Ates, Nurbay | |
dc.contributor.coauthor | Ahishali, Bulent | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Kaya, Mehmet | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T22:49:08Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Purpose: This study investigated the effects of cortical dysplasia (CD) on electrophysiology and blood-brain barrier (BBB) permeability in WAG/Rij rats with genetic absence epilepsy. Methods: Pregnant WAG/Rij rats were exposed to 145 cGy of gamma-irradiation on embryonic day 17 to induce CD. An electroencephalogram was recorded from cortices subdurally in the offspring of the pregnant animals. Horseradish peroxidase (HRP) was used as determinant of BBB permeability. Results: A massive tissue loss in the cerebral cortex was seen in WAG/Rij rats with CD (p < 0.05). There was a significant decrease in the number and duration of spike-and-wave discharges (SWDs) and an increase in the frequency of SWD5 in the WAG/Rij rats with CD when compared with the properties of SWD5 in intact WAG/Rij rats (p < 0.01). Ultrastructurally, the accumulation of HRP reaction products in the cerebral cortex and thalamus of WAG/Rij rats was significantly higher than that of control values (p < 0.01). The accumulation of HRP reaction products in the cerebral cortex and thalamus regions of WAG/Rij rats with CD increased and was higher than that of the control and WAG/Rij animals (p < 0.01). Conclusion: In our study, we showed that number and duration of SWDs decreased and SWD frequency increased in WAG/Rij rats with CD, suggesting a shift in seizure pattern. The association of these alterations with significant loss of cortical thickness and increased BBB permeability to HRP tracer may represent a causal relation of the EEG abnormalities with cerebral structural changes in these animals. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.openaccess | NO | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | TUBITAK [111S530] This study was supported by the Research Fund of TUBITAK (111S530). | |
dc.description.volume | 67 | |
dc.identifier.doi | 10.1016/j.yebeh.2016.11.001 | |
dc.identifier.eissn | 1525-5069 | |
dc.identifier.issn | 1525-5050 | |
dc.identifier.scopus | 2-s2.0-85009070811 | |
dc.identifier.uri | https://doi.org/10.1016/j.yebeh.2016.11.001 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/6452 | |
dc.identifier.wos | 395968000012 | |
dc.keywords | WAG/Rij rats | |
dc.keywords | Cortical dysplasia | |
dc.keywords | Epileptogenesis | |
dc.keywords | Blood-brain barrier | |
dc.keywords | Electron microscopy | |
dc.keywords | Electrophysiology | |
dc.language.iso | eng | |
dc.publisher | Academic Press Inc Elsevier Science | |
dc.relation.ispartof | Epilepsy & Behavior | |
dc.subject | Behavioral sciences | |
dc.subject | Clinical neurology | |
dc.subject | Psychiatry | |
dc.title | Changes in electroencephalographic characteristics and blood-brain barrier permeability in WAG/Rij rats with cortical dysplasia | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Kaya, Mehmet | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
relation.isOrgUnitOfPublication | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isOrgUnitOfPublication.latestForDiscovery | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isParentOrgUnitOfPublication | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e | |
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