Publication:
Changes in electroencephalographic characteristics and blood-brain barrier permeability in WAG/Rij rats with cortical dysplasia

dc.contributor.coauthorSahin, Deniz
dc.contributor.coauthorYilmaz, Canan Ugur
dc.contributor.coauthorOrhan, Nurcan
dc.contributor.coauthorArican, Nadir
dc.contributor.coauthorGurses, Candan
dc.contributor.coauthorAtes, Nurbay
dc.contributor.coauthorAhishali, Bulent
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKaya, Mehmet
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T22:49:08Z
dc.date.issued2017
dc.description.abstractPurpose: This study investigated the effects of cortical dysplasia (CD) on electrophysiology and blood-brain barrier (BBB) permeability in WAG/Rij rats with genetic absence epilepsy. Methods: Pregnant WAG/Rij rats were exposed to 145 cGy of gamma-irradiation on embryonic day 17 to induce CD. An electroencephalogram was recorded from cortices subdurally in the offspring of the pregnant animals. Horseradish peroxidase (HRP) was used as determinant of BBB permeability. Results: A massive tissue loss in the cerebral cortex was seen in WAG/Rij rats with CD (p < 0.05). There was a significant decrease in the number and duration of spike-and-wave discharges (SWDs) and an increase in the frequency of SWD5 in the WAG/Rij rats with CD when compared with the properties of SWD5 in intact WAG/Rij rats (p < 0.01). Ultrastructurally, the accumulation of HRP reaction products in the cerebral cortex and thalamus of WAG/Rij rats was significantly higher than that of control values (p < 0.01). The accumulation of HRP reaction products in the cerebral cortex and thalamus regions of WAG/Rij rats with CD increased and was higher than that of the control and WAG/Rij animals (p < 0.01). Conclusion: In our study, we showed that number and duration of SWDs decreased and SWD frequency increased in WAG/Rij rats with CD, suggesting a shift in seizure pattern. The association of these alterations with significant loss of cortical thickness and increased BBB permeability to HRP tracer may represent a causal relation of the EEG abnormalities with cerebral structural changes in these animals.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessNO
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipTUBITAK [111S530] This study was supported by the Research Fund of TUBITAK (111S530).
dc.description.volume67
dc.identifier.doi10.1016/j.yebeh.2016.11.001
dc.identifier.eissn1525-5069
dc.identifier.issn1525-5050
dc.identifier.scopus2-s2.0-85009070811
dc.identifier.urihttps://doi.org/10.1016/j.yebeh.2016.11.001
dc.identifier.urihttps://hdl.handle.net/20.500.14288/6452
dc.identifier.wos395968000012
dc.keywordsWAG/Rij rats
dc.keywordsCortical dysplasia
dc.keywordsEpileptogenesis
dc.keywordsBlood-brain barrier
dc.keywordsElectron microscopy
dc.keywordsElectrophysiology
dc.language.isoeng
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofEpilepsy & Behavior
dc.subjectBehavioral sciences
dc.subjectClinical neurology
dc.subjectPsychiatry
dc.titleChanges in electroencephalographic characteristics and blood-brain barrier permeability in WAG/Rij rats with cortical dysplasia
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKaya, Mehmet
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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