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A comparative meta-analysis of peripheral 8-hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) levels across mood episodes in bipolar disorder

dc.contributor.coauthorÇeli̇k, H. E. A.
dc.contributor.coauthorTuna, G.
dc.contributor.coauthorKüçükgöncü, S.
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorCeylan, Deniz
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:27:41Z
dc.date.issued2023
dc.description.abstractObjective: Oxidative DNA damage has been associated with the pathophysiology of bipolar disorder (BD) as one of the common pathways between increased medical comorbidity and premature aging in BD. Previous evidence shows increased levels of oxidatively induced DNA damage markers, 8-hydroxy-2′-deoxyguanosine (8-OHdG) or its tautomer 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG), in patients with BD in comparison to healthy individuals. With the current research, we aim to analyze data on peripheral (blood or urine) 8-OHdG/8-oxo-dG levels across mood states of BD using a meta-analytical approach. Method: A literature search was conducted using the databases PubMed, Scopus, and Web of Science to identify eligible studies (January 1989 to July 2022). Relevant studies were systematically reviewed; a random-effects meta-analysis and a meta-regression analysis were conducted. Results: The current meta-analysis included 12 studies consisting of 808 BD patients (390 in euthymia, 156 in mania, 137 in depression, 16 in mixed episode, 109 not specified) and 563 healthy controls. BD patients that were currently depressed had significantly higher levels of 8-OHdG/8-oxo-dG than healthy controls, while euthymic or manic patients did not differ from healthy controls. A meta-regression analysis showed sex distribution (being female) and older age to be significantly related to increased 8-OHdG/8-oxo-dG levels. Conclusion: Our findings suggest that 8-OHdG/8-oxo-dG may be a state-related marker of depression in BD and may be affected by older age and female gender.
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume151
dc.identifier.doi10.1016/j.psyneuen.2023.106078
dc.identifier.issn0306-4530
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85150340481
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85150340481&doi=10.1016%2fj.psyneuen.2023.106078&partnerID=40&md5=dc8000f70730a8f9b50d2a7789afcf43
dc.identifier.urihttps://hdl.handle.net/20.500.14288/11761
dc.identifier.wos955758500001
dc.keywords8-OHdG
dc.keywords8-oxo-dG
dc.keywordsBipolar disorder
dc.keywordsOxidative DNA damage
dc.language.isoeng
dc.publisherElsevier Ltd
dc.relation.ispartofPsychoneuroendocrinology
dc.subjectOxidative stress
dc.subjectAcetylcysteine
dc.subjectBipolar disorder
dc.titleA comparative meta-analysis of peripheral 8-hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) levels across mood episodes in bipolar disorder
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorÖzalp, Deniz Ceylan Tufan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscovery91bbe15d-017f-446b-b102-ce755523d939
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