Publication:
Diagnostic value of BRCA1-associated protein-1, glucose transporter-1 and desmin expression in the discrimination between reactive mesothelial proliferation and malignant mesothelioma in tissues and effusions

dc.contributor.coauthorÖnder, Sevgen
dc.contributor.coauthorÖzogul, Ece
dc.contributor.coauthorKoksal, Deniz
dc.contributor.coauthorSarinc Ulasli, Sevinc
dc.contributor.coauthorEmri, Salih
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorFırat, Pınar Arıkan
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-10T00:00:23Z
dc.date.issued2019
dc.description.abstractObjective: The aim of this study was to investigate the utility of BRCA1-associated protein-1 (BAP1), glucose transporter (GLUT)-1 and desmin expression by immunohistochemistry in the discrimination between reactive and malignant mesothelial proliferations. Methods: A total of 88 biopsies and 30 effusions from mesothelioma cases were studied. Control groups were composed of 35 tissues and 30 cell blocks. The 88 mesothelioma cases were from 43 males and 45 females (mean age 56 years). Tumours were mostly localised to pleura (66/88, 75%) and of epithelioid histology (75/88, 85%). Cytology samples were from 17 males and 13 females (mean age 58 years), and 16 pleural and 14 peritoneal effusions. Twenty cytology cases had corresponding tissue biopsies. Results: BAP1 loss was detected in 61/88 (69%) tissues and in 20/30 (67%) cytology samples from mesothelioma with a specificity of 100% for both sampling methods. BAP1 loss was observed more frequently in pleural and biphasic tumours. GLUT-1 immunoreactivity was identified in 54/81 (67%) and 23/25 (92%) malignant tissues and effusions, and in 6/33 (18%) and 6/30 (20%) benign tissues and effusions, respectively. Desmin loss was observed in 74/80 (92%) malignant biopsy samples, 16/21 (76%) malignant effusions and 10/34 (29%) of benign tissues, but in none of the reactive effusions. Concordance rate of results between biopsy and cytology was as follows: BAP1 20/20 (100%); GLUT-1 13/18 (72%); and desmin 10/14 (71%). Conclusions: BAP1, GLUT-1 and desmin are useful markers in the discrimination between reactive and malignant mesothelial proliferations. BAP1 loss seems to be diagnostic for mesotheliomas both in biopsy and cytology samples. © 2019 John Wiley & Sons Ltd
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue6
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume30
dc.identifier.doi10.1111/cyt.12738
dc.identifier.issn0956-5507
dc.identifier.scopus2-s2.0-85069764796
dc.identifier.urihttps://doi.org/10.1111/cyt.12738
dc.identifier.urihttps://hdl.handle.net/20.500.14288/15781
dc.keywordsBRCA1-associated protein-1
dc.keywordsDesmin
dc.keywordsGlucose transporter-1
dc.keywordsImmunohistochemistry
dc.keywordsMesothelioma
dc.keywordsReactive mesothelial proliferation
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofCytopathology
dc.subjectCell biology
dc.subjectPathology
dc.titleDiagnostic value of BRCA1-associated protein-1, glucose transporter-1 and desmin expression in the discrimination between reactive mesothelial proliferation and malignant mesothelioma in tissues and effusions
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorFırat, Pınar Arıkan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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