Publication: Long-lasting simultaneous epidermal and dermal microneedle-enabled drug delivery
dc.contributor.department | KUTTAM (Koç University Research Center for Translational Medicine) | |
dc.contributor.department | Department of Mechanical Engineering | |
dc.contributor.department | KUAR (KU Arçelik Research Center for Creative Industries) | |
dc.contributor.department | KUIS AI (Koç University & İş Bank Artificial Intelligence Center) | |
dc.contributor.department | KUH (Koç University Hospital) | |
dc.contributor.department | Graduate School of Health Sciences | |
dc.contributor.department | Graduate School of Sciences and Engineering | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Sitti, Metin | |
dc.contributor.kuauthor | Taşoğlu, Savaş | |
dc.contributor.kuauthor | Vural, Seçil | |
dc.contributor.kuauthor | Ağcaoğlu, Orhan | |
dc.contributor.kuauthor | Büyükbabani, Nesimi | |
dc.contributor.kuauthor | Khoshbakht, Saba | |
dc.contributor.kuauthor | Farshi, Sara Soltanabadi | |
dc.contributor.kuauthor | Sarabi, Misagh Rezapour | |
dc.contributor.kuauthor | Saltık, Zeynep | |
dc.contributor.schoolcollegeinstitute | College of Engineering | |
dc.contributor.schoolcollegeinstitute | GRADUATE SCHOOL OF HEALTH SCIENCES | |
dc.contributor.schoolcollegeinstitute | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
dc.contributor.schoolcollegeinstitute | KUH (KOÇ UNIVERSITY HOSPITAL) | |
dc.contributor.schoolcollegeinstitute | Research Center | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2025-03-06T20:57:18Z | |
dc.date.issued | 2024 | |
dc.description.abstract | Different skin diseases, such as cancers, inflammatory conditions, and bacterial infections, manifest at distinct skin depths. Microneedle arrays, recognized for their painless and minimally invasive drug administration, can be customized to penetrate these layers simultaneously. Here, the design of the microneedles (MNs) in nonlinear ways with diverse needle heights on the array enabling concurrent drug delivery to various skin layers is engineered. Additionally, varying the base diameter of the needles in the array facilitates prolonged or intermittent drug release, depending on the biodegradation kinetics of these needles. MNs, microfabricated with a biocompatible and biodegradable polymer, are validated by skin administration. The nonlinear design of the MNs on the array introduces a novel perspective on addressing skin diseases at varying depths of the skin. Microneedle arrays (MNAs) with nonlinear designs are engineered to address skin diseases at varying depths by enabling simultaneous long-lasting drug delivery. The MNAs feature needles of different heights and base diameters, allowing targeted, prolonged, or intermittent drug release based on biodegradation kinetics. Biodegradable MNAs are validated through skin administration, offering a novel approach to treating diverse skin conditions. image | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | TÜBİTAK | |
dc.description.sponsorship | The authors kindly acknowledge Maryam Kahvazizadeh for her kind efforts for helping with SEM photos. S.T. acknowledges TÜBİTAK 2232 International Fellowship for Outstanding Researchers Award (118C391), Alexander von Humboldt Research Fellowship for Experienced Researchers, Marie Sklodowska-Curie Individual Fellowship (101003361), and Royal Academy Newton-Katip Celebi Transforming Systems Through Partnership award (120N019) for financial support of this research. This work was partially supported by Science Academy's Young Scientist Awards Program (BAGEP), Outstanding Young Scientists Awards (GEB and Idot;P), and Bilim Kahramanlari Dernegi The Young Scientist Award. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the TUEB and Idot;TAK. This study was conducted using the service and infrastructure of Koc University Translational Medicine Research Center (KUTTAM). | |
dc.identifier.doi | 10.1002/admt.202400980 | |
dc.identifier.grantno | TÜBİTAK 2232 International Fellowship for Outstanding Researchers Award [118C391];Alexander von Humboldt Research Fellowship for Experienced Researchers;Marie Sklodowska-Curie Individual Fellowship [101003361];Royal Academy Newton-Katip Celebi Transforming Systems Through Partnership award [120N019];Science Academy's Young Scientist Awards Program (BAGEP);Outstanding Young Scientists Awards (GEBIdot;P);Bilim Kahramanlari Dernegi The Young Scientist Award | |
dc.identifier.issn | 2365-709X | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85204297424 | |
dc.identifier.uri | https://doi.org/10.1002/admt.202400980 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/27194 | |
dc.identifier.wos | 1315137800001 | |
dc.keywords | Dermal delivery | |
dc.keywords | Drug delivery | |
dc.keywords | Epidermal delivery | |
dc.keywords | Long-lasting | |
dc.keywords | Microneedle | |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartof | ADVANCED MATERIALS TECHNOLOGIES | |
dc.subject | Materials science | |
dc.title | Long-lasting simultaneous epidermal and dermal microneedle-enabled drug delivery | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.publication.orgunit1 | College of Engineering | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit1 | GRADUATE SCHOOL OF HEALTH SCIENCES | |
local.publication.orgunit1 | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
local.publication.orgunit1 | Research Center | |
local.publication.orgunit1 | KUH (KOÇ UNIVERSITY HOSPITAL) | |
local.publication.orgunit2 | Department of Mechanical Engineering | |
local.publication.orgunit2 | KUTTAM (Koç University Research Center for Translational Medicine) | |
local.publication.orgunit2 | KUAR (KU Arçelik Research Center for Creative Industries) | |
local.publication.orgunit2 | KUIS AI (Koç University & İş Bank Artificial Intelligence Center) | |
local.publication.orgunit2 | KUH (Koç University Hospital) | |
local.publication.orgunit2 | School of Medicine | |
local.publication.orgunit2 | Graduate School of Health Sciences | |
local.publication.orgunit2 | Graduate School of Sciences and Engineering | |
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