Publication:
Long-lasting simultaneous epidermal and dermal microneedle-enabled drug delivery

dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentDepartment of Mechanical Engineering
dc.contributor.departmentKUAR (KU Arçelik Research Center for Creative Industries)
dc.contributor.departmentKUIS AI (Koç University & İş Bank Artificial Intelligence Center)
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSitti, Metin
dc.contributor.kuauthorTaşoğlu, Savaş
dc.contributor.kuauthorVural, Seçil
dc.contributor.kuauthorAğcaoğlu, Orhan
dc.contributor.kuauthorBüyükbabani, Nesimi
dc.contributor.kuauthorKhoshbakht, Saba
dc.contributor.kuauthorFarshi, Sara Soltanabadi
dc.contributor.kuauthorSarabi, Misagh Rezapour
dc.contributor.kuauthorSaltık, Zeynep
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T20:57:18Z
dc.date.issued2024
dc.description.abstractDifferent skin diseases, such as cancers, inflammatory conditions, and bacterial infections, manifest at distinct skin depths. Microneedle arrays, recognized for their painless and minimally invasive drug administration, can be customized to penetrate these layers simultaneously. Here, the design of the microneedles (MNs) in nonlinear ways with diverse needle heights on the array enabling concurrent drug delivery to various skin layers is engineered. Additionally, varying the base diameter of the needles in the array facilitates prolonged or intermittent drug release, depending on the biodegradation kinetics of these needles. MNs, microfabricated with a biocompatible and biodegradable polymer, are validated by skin administration. The nonlinear design of the MNs on the array introduces a novel perspective on addressing skin diseases at varying depths of the skin. Microneedle arrays (MNAs) with nonlinear designs are engineered to address skin diseases at varying depths by enabling simultaneous long-lasting drug delivery. The MNAs feature needles of different heights and base diameters, allowing targeted, prolonged, or intermittent drug release based on biodegradation kinetics. Biodegradable MNAs are validated through skin administration, offering a novel approach to treating diverse skin conditions. image
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipThe authors kindly acknowledge Maryam Kahvazizadeh for her kind efforts for helping with SEM photos. S.T. acknowledges TÜBİTAK 2232 International Fellowship for Outstanding Researchers Award (118C391), Alexander von Humboldt Research Fellowship for Experienced Researchers, Marie Sklodowska-Curie Individual Fellowship (101003361), and Royal Academy Newton-Katip Celebi Transforming Systems Through Partnership award (120N019) for financial support of this research. This work was partially supported by Science Academy's Young Scientist Awards Program (BAGEP), Outstanding Young Scientists Awards (GEB and Idot;P), and Bilim Kahramanlari Dernegi The Young Scientist Award. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the TUEB and Idot;TAK. This study was conducted using the service and infrastructure of Koc University Translational Medicine Research Center (KUTTAM).
dc.identifier.doi10.1002/admt.202400980
dc.identifier.grantnoTÜBİTAK 2232 International Fellowship for Outstanding Researchers Award [118C391];Alexander von Humboldt Research Fellowship for Experienced Researchers;Marie Sklodowska-Curie Individual Fellowship [101003361];Royal Academy Newton-Katip Celebi Transforming Systems Through Partnership award [120N019];Science Academy's Young Scientist Awards Program (BAGEP);Outstanding Young Scientists Awards (GEBIdot;P);Bilim Kahramanlari Dernegi The Young Scientist Award
dc.identifier.issn2365-709X
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85204297424
dc.identifier.urihttps://doi.org/10.1002/admt.202400980
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27194
dc.identifier.wos1315137800001
dc.keywordsDermal delivery
dc.keywordsDrug delivery
dc.keywordsEpidermal delivery
dc.keywordsLong-lasting
dc.keywordsMicroneedle
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofADVANCED MATERIALS TECHNOLOGIES
dc.subjectMaterials science
dc.titleLong-lasting simultaneous epidermal and dermal microneedle-enabled drug delivery
dc.typeJournal Article
dspace.entity.typePublication
local.publication.orgunit1College of Engineering
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1Research Center
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2Department of Mechanical Engineering
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2KUAR (KU Arçelik Research Center for Creative Industries)
local.publication.orgunit2KUIS AI (Koç University & İş Bank Artificial Intelligence Center)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
local.publication.orgunit2Graduate School of Sciences and Engineering
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