Publication:
Association between BRAFV600E mutation and the clinicopathological features in incidental papillary thyroid microcarcinoma: a single-center study in Turkish patients

dc.contributor.coauthorÜren, Nihal
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSezer, Havva
dc.contributor.kuauthorDereli, Dilek Yazıcı
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:44:04Z
dc.date.issued2020
dc.description.abstractObjective: In this study, we evaluated the influences of BRAF(V600E) mutation on clinicopathological features in incidentally found papillary thyroid microcarcinomas (PTMCs). Methods: This retrospective cohort study included 72 patients with PTMC who underwent surgery from 2008 to 2012. The mean follow-up of the whole cohort was three years. DNA was isolated using QIAamp DNA formalin-fixed, paraffin-embedded (FFPE) tissue kit. BRAF gene was amplified by the polymerase chain reaction-restriction fragment length (PCR-RFL) polymorphism method with the following primers. The clinicopathologic features (age, gender, histologic subtype, tumor size, presence of tumor capsule, bilaterality, multifocality, extrathyroidal extension (ETE), thyroid capsular invasion, presence of Hashimoto's thyroiditis, lymph node metastasis (LNM) and distant metastasis) were compared between the BRAF (+) and BRAF (-) patient groups. Results: BRAF(V600E) mutation was detected in 30 of the 72 patients (41.6%). The presence of the mutation was statically significantly associated with classic variant (p=0.046), invasion of thyroid capsule (p=0.002) and absence of tumor capsule (p=0.003). Conclusion: Although incidental PTMCs positive for the BRAF(V600E) mutation had more invasive behavior, the presence of the mutation was not associated with recurrences within three years of follow-up.
dc.description.indexedbyWOS
dc.description.indexedbyPubMed
dc.description.indexedbyTR Dizin
dc.description.issue4
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipKocaeli University Faculty of Medicine This research was supported by research funds from Kocaeli University Faculty of Medicine.
dc.description.volume7
dc.identifier.doi10.14744/nci.2020.69586
dc.identifier.issn2148-4902
dc.identifier.quartileN/A
dc.identifier.urihttps://doi.org/10.14744/nci.2020.69586
dc.identifier.urihttps://hdl.handle.net/20.500.14288/13589
dc.identifier.wos564196700002
dc.keywordsBRAF(V600E)
dc.keywordsClinicopathological features
dc.keywordsIncidental
dc.keywordsPapillary thyroid microcarcinoma
dc.keywordsBRAF V600E
dc.keywordsMutation
dc.keywordsLymph-node metastasis
dc.keywordsBraf(V600e) mutation
dc.keywordsHashimotos-thyroiditis
dc.keywordsPrognostic factors
dc.keywordsClinical outcomes
dc.keywordsHigh prevalence
dc.keywordsCancer
dc.keywordsCarcinoma
dc.keywordsRecurrence
dc.language.isoeng
dc.publisherKare Yayıncılık
dc.relation.ispartofNorthern Clinics of Istanbul
dc.subjectMedicine
dc.subjectInternal medicine
dc.titleAssociation between BRAFV600E mutation and the clinicopathological features in incidental papillary thyroid microcarcinoma: a single-center study in Turkish patients
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorSezer, Havva
local.contributor.kuauthorYazıcı, Dilek
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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