Publication:
Abnormal blood rheology and chronic low grade inflammation: possible risk factors for accelerated atherosclerosis and coronary artery disease in Lewis negative subjects

dc.contributor.coauthorAlexy, Tamas
dc.contributor.coauthorPais, Eszter
dc.contributor.coauthorWenby, Rosalinda B.
dc.contributor.coauthorMack, Wendy J.
dc.contributor.coauthorHodis, Howard N.
dc.contributor.coauthorKono, Naoko
dc.contributor.coauthorWang, Jun
dc.contributor.coauthorFisher, Timothy C.
dc.contributor.coauthorMeiselman, Herbert J.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBaşkurt, Oğuz Kerim
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:26:53Z
dc.date.issued2015
dc.description.abstractObjective: To test the hypothesis that abnormal hemorheology and chronic low-grade inflammation are more prevalent in Lewis negative individuals, possibly contributing to premature atherosclerosis. Methods and results: We enrolled 223 healthy subjects (154 females, mean age: 64yrs). Conventional risk factors, markers of inflammation and hemorheological profiles were measured; Lewis blood group was determined by serology. Conventional risk factors (age, gender, BMI, blood pressure, lipid profile, smoking habit) did not differ among Lewis phenotypes. However, markers of inflammation (WBC, hs-CRP, ESR) were significantly elevated and rheological parameters (RBC aggregation, plasma viscosity) were abnormal in Lewis negative subjects, especially when compared to the Le(a-b+) group. Conclusions: With a prevalence of 33% in select populations, our data support the hypothesis that Le(a-b-) represents a pro-inflammatory phenotype that may contribute to the elevated cardiovascular risk in this group. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume239
dc.identifier.doi10.1016/j.atherosclerosis.2015.01.015
dc.identifier.eissn1879-1484
dc.identifier.issn0021-9150
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-84921518306
dc.identifier.urihttps://doi.org/10.1016/j.atherosclerosis.2015.01.015
dc.identifier.urihttps://hdl.handle.net/20.500.14288/11625
dc.identifier.wos349753800036
dc.keywordsLewis negative phenotype
dc.keywordsAtherosclerosis
dc.keywordsInflammation
dc.keywordsBlood rheology
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofAtherosclerosis
dc.subjectCardiac and cardiovascular systems
dc.subjectPeripheral vascular disease
dc.titleAbnormal blood rheology and chronic low grade inflammation: possible risk factors for accelerated atherosclerosis and coronary artery disease in Lewis negative subjects
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorBaşkurt, Oğuz Kerim
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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