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Epidemiological characteristics of hepatitis B and C in patients with inflammatory arthritis: implications from treasure database

dc.contributor.coauthorErsözlü, Emine Duygu
dc.contributor.coauthorEkici, Mustafa
dc.contributor.coauthorCoşkun, Belkis Nihan
dc.contributor.coauthorBadak, Suade Özlem
dc.contributor.coauthorBilgin, Emre
dc.contributor.coauthorKalyoncu, Umut
dc.contributor.coauthorYağız, Burcu
dc.contributor.coauthorPehlivan, Yavuz
dc.contributor.coauthorKüçükşahin, Orhan
dc.contributor.coauthorErden, Abdulsamet
dc.contributor.coauthorSolmaz, Dilek
dc.contributor.coauthorAtagündüz, Pamir
dc.contributor.coauthorKimyon, Gezmiş
dc.contributor.coauthorBeş, Cemal
dc.contributor.coauthorÇolak, Seda
dc.contributor.coauthorMercan, Rıdvan
dc.contributor.coauthorKaşifoğlu, Timuçin
dc.contributor.coauthorEmmungil, Hakan
dc.contributor.coauthorAteş, Aşkın
dc.contributor.coauthorKoca, Süleyman Serdar
dc.contributor.coauthorKiraz, Sedat
dc.contributor.coauthorErtenli, İhsan
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKanıtez, Nilüfer Alpay
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:32:02Z
dc.date.issued2023
dc.description.abstractObjectives: This study aimed to evaluate the hepatitis B (HBV) and C (HCV) frequency and clinical characteristics among patients with rheumatoid arthritis (RA) or spondyloarthritis (SpA) who receive biological treatments. Patients and methods: The observational study was conducted with patients from the TReasure database, a web-based prospective observational registry collecting data from 17 centers across Türkiye, between December 2017 and June 2021. From this database, 3,147 RA patients (2,502 males, 645 females; median age 56 years; range, 44 to 64 years) and 6,071 SpA patients (2,709 males, 3,362 females; median age 43 years; range, 36 to 52 years) were analyzed in terms of viral hepatitis, patient characteristics, and treatments used. Results: The screening rate for HBV was 97% in RA and 94.2% in SpA patients. Hepatitis B surface antigen (HBsAg) positivity rates were 2.6% and 2%, hepatitis B surface antibody positivity rates were 32.3% and 34%, hepatitis B core antibody positivity rates were 20.3% and 12.5%, HBV DNA (deoxyribonucleic acid) positivity rates were 3.5% and 12.5%, and antibody against HCV positivity rates were 0.8% and 0.3% in RA and SpA patients, respectively. The HBsAg-positive patients were older and had more comorbidities, including hypertension, diabetes, and coronary artery disease. In addition, rheumatoid factor (RF) positivity was more common in HBsAg-positive cases. The most frequently prescribed biologic disease-modifying antirheumatic drugs were adalimumab (28.5%), etanercept (27%), tofacitinib (23.4%), and tocilizumab (21.5%) in the RA group and adalimumab (48.1%), etanercept (31.4%), infliximab (22.6%), and certolizumab (21.1%) in the SpA group. Hepatitis B reactivation was observed in one RA patient during treatment, who received rituximab and prophylaxis with tenofovir. Conclusion: The epidemiological characteristics of patients with rheumatic diseases and viral hepatitis are essential for effective patient management. This study provided the most recent epidemiological characteristics from the prospective TReasure database, one of the comprehensive registries in rheumatology practice. © 2023 Turkish League Against Rheumatism. All rights reserved.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume38
dc.identifier.doi10.46497/ArchRheumatol.2023.9504
dc.identifier.eissn26186500
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85175151998
dc.identifier.urihttps://doi.org/10.46497/ArchRheumatol.2023.9504
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26347
dc.identifier.wos1108061700012
dc.keywordsHBV
dc.keywordsHCV
dc.keywordsRheumatic diseases
dc.keywordsRheumatoid arthritis
dc.keywordsSpondyloarthritis
dc.keywordsTReasure
dc.keywordsViral hepatitis
dc.keywordsViral reactivation
dc.language.isoeng
dc.publisherTurkish League Against Rheumatism (TLAR)
dc.relation.ispartofArchives of Rheumatology
dc.subjectMedicine
dc.titleEpidemiological characteristics of hepatitis B and C in patients with inflammatory arthritis: implications from treasure database
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKanıtez, Nilüfer Alpay
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
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relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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