Publication:
Anxiety symptoms and disorders during the COVID-19 pandemic in children and adolescents: systematic review and meta-analysis

dc.contributor.coauthorPanchal, Urvashi
dc.contributor.coauthorVaquerizo-Serrano, Julio David
dc.contributor.coauthorConde-Ghigliazza, Ileana
dc.contributor.coauthorMarchini, Simone
dc.contributor.coauthorPociute, Kamile
dc.contributor.coauthorKayan Ocakoğlu, Binay
dc.contributor.coauthorSanchez-Roman, Szarah
dc.contributor.coauthorOri, Dorottya
dc.contributor.coauthorCatalan, Ana
dc.contributor.coauthorAlameda, Luis
dc.contributor.coauthorCortese, Samuele
dc.contributor.coauthorSalazar de Pablo, Gonzalo
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorGenç, Herdem Aslan
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:28:21Z
dc.date.issued2023
dc.description.abstractBackground and Objectives: The COVID-19 pandemic and its associated factors have been shown to affect anxiety levels of young people. We meta-analytically assessed the prevalence of anxiety symptoms and anxiety disorders in children and adolescents during the pandemic, and the predictors and moderating factors influencing anxiety. Methods: Multiple databases and registers were searched in this PRISMA and MOOSE-compliant systematic review and meta-analysis (PROSPERO:CRD42021266695) until 27/06/2021. We included individual studies evaluating the prevalence and characteristics of anxiety symptoms or anxiety disorders in children and adolescents (mean age ≤18 years), during the COVID-19 pandemic. Data extraction and quality assessment were carried out by independent authors. Random-effects meta-analyses of the prevalence of anxiety symptoms and anxiety disorders were conducted using Comprehensive Meta-Analysis (CMA) V3. Results: 74 articles (total participant sample=478,882) were included (mean age=13.4 years, 52.3% female). The pooled rate of children and adolescents fulfilling diagnostic criteria for anxiety disorders was 13.0% (95%CI=4.9–30.1); the pooled prevalence of anxiety symptoms was 26.5% (95%CI=20.3–33.9). Anxiety symptoms were significantly more prevalent in females than males (B = 0.103, p<.001), significantly higher during the second wave of COVID-19, following July 2020, than during the first wave, prior to June 2020, (Q= 8.136, p=.017), and during school closure (Q= 8.100, p=.014). Quality of included studies was overall moderate. Conclusions: There is a high prevalence of anxiety symptoms in children and adolescents during the COVID-19 pandemic, especially amongst females. This study identifies vulnerable groups, risk, and protective factors, which is crucial to developing clinical practice to prevent further mental health deterioration in young people.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue4
dc.description.openaccessAll Open Access; Hybrid Gold Open Access
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipDr Salazar de Pablo and Dr Vaquerizo Serrano are supported by the Alicia Koplowitz Foundation. Dr Catalan has received grant support from the Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness.
dc.description.volume37
dc.identifier.doi10.1016/j.ejpsy.2023.06.003
dc.identifier.issn0213-6163
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85173115382
dc.identifier.urihttps://doi.org/10.1016/j.ejpsy.2023.06.003
dc.identifier.urihttps://hdl.handle.net/20.500.14288/25703
dc.identifier.wos1164996300001
dc.keywordsAdolescents
dc.keywordsAnxiety
dc.keywordsChildren
dc.keywordsCOVID-19
dc.language.isoeng
dc.publisherElsevier Espana S.L.U
dc.relation.grantnoFundación Alicia Koplowitz; Ministerio de Economía y Competitividad, MINECO; Instituto de Salud Carlos III, ISCIII
dc.relation.ispartofEuropean Journal of Psychiatry
dc.subjectPsychiatry
dc.titleAnxiety symptoms and disorders during the COVID-19 pandemic in children and adolescents: systematic review and meta-analysis
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorGenç, Herdem Aslan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2School of Medicine
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