Publication:
Urticarial vasculitis differs from chronic spontaneous urticaria in time to diagnosis, clinical presentation, and need for anti-inflammatory treatment: an international prospective UCARE study

dc.contributor.coauthorBonnekoh, Hanna
dc.contributor.coauthorJelden-Thurm, Jannis
dc.contributor.coauthorAllenova, Anastasiia
dc.contributor.coauthorChen, Yudi
dc.contributor.coauthorCherrez-Ojeda, Ivan
dc.contributor.coauthorDanilycheva, Inna
dc.contributor.coauthorDorofeeva, Irina
dc.contributor.coauthorCriado, Roberta Fachini Jardim
dc.contributor.coauthorCriado, Paulo Ricardo
dc.contributor.coauthorAkkor, Asli Gelincik
dc.contributor.coauthorHawro, Tomasz
dc.contributor.coauthorKhoshkhui, Maryam
dc.contributor.coauthorMetz, Martin
dc.contributor.coauthorNasr, Iman
dc.contributor.coauthorStec, Michal
dc.contributor.coauthorZhao, Zuotao
dc.contributor.coauthorAulenbacher, Felix
dc.contributor.coauthorSalameh, Pascale
dc.contributor.coauthorAltrichter, Sabine
dc.contributor.coauthorGoncalo, Margarida
dc.contributor.coauthorGimenez-Arnau, Ana
dc.contributor.coauthorMaurer, Marcus
dc.contributor.coauthorKrause, Karoline
dc.contributor.coauthorKolkhir, Pavel
dc.contributor.departmentSchool of Medicine
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:32:36Z
dc.date.issued2023
dc.description.abstractBACKGROUND: Chronic spontaneous urticaria (CSU) and urticarial vasculitis (UV) share several clinical features including the occurrence of wheals. As of yet, the criteria for differentiating the 2 disorders are not clearly defined. OBJECTIVE: Here, we aimed to identify differences, similarities, and the likelihood for specific clinical features in patients with UV versus those with CSU. METHODS: Across 10 Urticaria Centers of Reference and Excellence, 106 patients with skin biopsyeconfirmed UV and 126 patients with CSU were prospectively recruited to complete a questionnaire on the clinical features, course, and response to treatment of their disease. RESULTS: As compared with CSU, patients with UV more often experienced postinflammatory skin hyperpigmentation, wheals of >= 24-hour duration, eye inflammation, and fever (6.9, 4.0, 3.6, and 2.4 times, respectively). Clinical features that increased the risk for UV diagnosis when present at the onset of disease included wheals of >= 24-hour duration (7.3-fold), pain of the skin (7.0-fold), postinflammatory hyperpigmen-tation (4.1-fold), and fatigue (3.1-fold). The diagnostic delay was markedly longer for normocomplementemic UV as compared with hypocomplementemic UV and CSU (21 vs 5 vs 6 months, respectively). Oral corticosteroids and omali-zumab were the most effective treatments in patients with UV and CSU, respectively. Patients with UV showed a higher need for immunosuppressive and anti-inflammatory thera-pies than patients with CSU. CONCLUSIONS: Long wheal duration, skin pain and hyperpigmentation, and systemic symptoms point to UV rather than CSU as the underlying disease and should prompt further diagnostic workup including a skin biopsy. (c) 2023 American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2023;11:2900-10)
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue9
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThis study was performed and supported by the network of Urticaria Centers of Reference and Excellence (UCAREs, https://ga2len-ucare.com /) of the Global Allergy and Asthma European Network (GA 2 LEN) .
dc.description.volume11
dc.identifier.doi10.1016/j.jaip.2023.06.030
dc.identifier.eissn2213-2201
dc.identifier.issn2213-2198
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85165002433
dc.identifier.urihttps://doi.org/10.1016/j.jaip.2023.06.030
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26451
dc.identifier.wos1077735100001
dc.keywordsChronic spontaneous urticaria
dc.keywordsUrticarial vasculitis
dc.keywordsDiagnosis
dc.keywordsCriteria
dc.keywordsUrticaria centers of reference and excellence
dc.language.isoeng
dc.publisherElsevier
dc.relation.grantnonetwork of Urticaria Centers of Reference and Excellence (UCAREs) of Global Allergy and Asthma European Network (GA 2 LEN)
dc.relation.ispartofJournal of Allergy and Clinical Immunology-in Practice
dc.subjectAllergy
dc.subjectImmunology
dc.titleUrticarial vasculitis differs from chronic spontaneous urticaria in time to diagnosis, clinical presentation, and need for anti-inflammatory treatment: an international prospective UCARE study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKocatürk, Emek
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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