A rare case of sudden bilateral eosinophilic cellulitis mimicking scleredema: case report and review of infantile cases

Abstract

Eosinophilic cellulitis (EC), also known as Wells syndrome, presents as sudden fever, erythematous and edematous, pruritic plaques, and/or vesiculobullous lesions, and is exceptionally rare in infants. We report a case of a 7-month-old female with bilateral infantile EC resembling scleredema. The condition was characterized by acute fever, edema, and erythema from the wrists to the elbows. Histopathological examination showed spongiosis, intense inflammatory infiltration, numerous eosinophils, and collagen degeneration (flame figures), confirming EC. Treatment with systemic steroids and topical creams resulted in rapid resolution of lesions within a week, with no recurrence during a 1-year follow-up.