The 2022 Assisi Think Tank Meeting: white paper on optimising radiation therapy for breast cancer

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Publication Date

2023

Advisor

Institution Author

Bölükbaşı, Yasemin

Co-Authors

Aristei, C.
Kaidar-Person, O.
Boersma, L.
Leonardi, M. C.
Offersen, B.
Franco, P.
Arenas, M.
Bourgier, C.
Pfeffer, R.
Kouloulias, V

Journal Title

Journal ISSN

Volume Title

Publisher:

Elsevier Science Inc

Type

Review
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Abstract

The present white paper, referring to the 4th Assisi Think Tank Meeting on breast cancer, reviews state-of-the-art data, on-going studies and research proposals. <70% agreement in an online questionnaire identified the following clinical challenges: 1: Nodal RT in patients who have a) 1-2 positive sentinel nodes without ALND (axillary lymph node dissection); b) cN1 disease transformed into ypN0 by primary systemic therapy and c) 1-3 positive nodes after mastectomy and ALND. 2. The optimal combination of RT and immunotherapy (IT), patient selection, IT-RT timing, and RT optimal dose, fractionation and target volume. Most experts agreed that RT-IT combination does not enhance toxicity. 3: Re-irradiation for local relapse converged on the use of partial breast irradiation after second breast conserving surgery. Hyperthermia aroused support but is not widely available. Further studies are required to finetune best practice, especially given the increasing use of re-irradiation.

Description

Subject

Oncology, Hematology

Citation

Endorsement

Review

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