Publication: High AST/ALT ratio is associated with cardiac involvement in acute COVID-19 patients
dc.contributor.coauthor | Karatas, Mesut | |
dc.contributor.coauthor | Keles, Nursen | |
dc.contributor.coauthor | Parsova, Kemal Emrecan | |
dc.contributor.coauthor | Ciftci, Hatice Ozge | |
dc.contributor.coauthor | Kahraman, Erkan | |
dc.contributor.coauthor | Durak, Furkan | |
dc.contributor.coauthor | Kocogullari, Cevdet Ugur | |
dc.contributor.coauthor | Yiyit, Nurettin | |
dc.contributor.department | Graduate School of Sciences and Engineering | |
dc.contributor.kuauthor | Özkök, Serçin | |
dc.contributor.schoolcollegeinstitute | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
dc.date.accessioned | 2025-01-19T10:33:33Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Background and Objectives: We aimed to assess the effect of AST/ALT ratio on echocardiographic and cardiac magnetic resonance imaging (CMRI) parameters after COVID-19 patients recover. Materials and Methods: 87 patients with COVID-19 were included in the study. The patients were hospitalized with COVID-19 pneumonia, but the patients did not need intensive care unit follow-up or non-invasive mechanical ventilation support. After a discharge and two weeks following the positive swab test result, patients were considered eligible if they had any symptoms. Transthoracic echocardiography (TTE) was performed within 24 h prior to CMRI. The median value of AST/ALT ratio was found, and the study population was divided into two subgroups based on the median AST/ALT ratio value. The clinical features, blood test, TTE and CMRI results were compared between subgroups. Results: C-reactive protein, D-dimer and fibrinogen were found to be significantly higher in patients with high AST/ALT ratio. LVEF, TAPSE, S', and FAC were significantly lower in patients with high AST/ALT ratio. LV-GLS were significantly lower in patients with high AST/ALT ratio. In CMRI, native T1 mapping signal, native T2 mapping signal and extracellular volume raised significantly in patients with high AST/ALT ratio. Right ventricle stroke volume and right ventricle ejection fraction were significantly lower in patients with high AST/ALT ratio, but right ventricle end systolic volume was significantly higher in patients with high AST/ALT ratio. Conclusion: High AST/ALT ratio is related to impaired right ventricular function parameters with CMRI and echocardiography after recovery from acute COVID-19. Assessment of AST/ALT ratio at hospital admission may be used to assess the risk of cardiac involvement in COVID-19 disease, and these patients may require closer follow-up during and after the course of COVID-19. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 6 | |
dc.description.openaccess | gold, Green Published | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 59 | |
dc.identifier.doi | 10.3390/medicina59061163 | |
dc.identifier.eissn | 1648-9144 | |
dc.identifier.issn | 1010-660X | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85163727902 | |
dc.identifier.uri | https://doi.org/10.3390/medicina59061163 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/26625 | |
dc.identifier.wos | 1016338100001 | |
dc.keywords | COVID 19 | |
dc.keywords | AST | |
dc.keywords | ALT ratio | |
dc.keywords | De ritis ratio | |
dc.keywords | Cardiac magnetic resonance imaging | |
dc.keywords | Cardiac imaging | |
dc.keywords | Speckle tracking echocardiography | |
dc.language.iso | eng | |
dc.publisher | MDPI | |
dc.relation.ispartof | Medicina-Lithuania | |
dc.subject | Medicine | |
dc.title | High AST/ALT ratio is associated with cardiac involvement in acute COVID-19 patients | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Özkök, Serçin | |
local.publication.orgunit1 | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
local.publication.orgunit2 | Graduate School of Sciences and Engineering | |
relation.isOrgUnitOfPublication | 3fc31c89-e803-4eb1-af6b-6258bc42c3d8 | |
relation.isOrgUnitOfPublication.latestForDiscovery | 3fc31c89-e803-4eb1-af6b-6258bc42c3d8 | |
relation.isParentOrgUnitOfPublication | 434c9663-2b11-4e66-9399-c863e2ebae43 | |
relation.isParentOrgUnitOfPublication.latestForDiscovery | 434c9663-2b11-4e66-9399-c863e2ebae43 |
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