Publication:
High AST/ALT ratio is associated with cardiac involvement in acute COVID-19 patients

dc.contributor.coauthorKaratas, Mesut
dc.contributor.coauthorKeles, Nursen
dc.contributor.coauthorParsova, Kemal Emrecan
dc.contributor.coauthorCiftci, Hatice Ozge
dc.contributor.coauthorKahraman, Erkan
dc.contributor.coauthorDurak, Furkan
dc.contributor.coauthorKocogullari, Cevdet Ugur
dc.contributor.coauthorYiyit, Nurettin
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.kuauthorÖzkök, Serçin
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.date.accessioned2025-01-19T10:33:33Z
dc.date.issued2023
dc.description.abstractBackground and Objectives: We aimed to assess the effect of AST/ALT ratio on echocardiographic and cardiac magnetic resonance imaging (CMRI) parameters after COVID-19 patients recover. Materials and Methods: 87 patients with COVID-19 were included in the study. The patients were hospitalized with COVID-19 pneumonia, but the patients did not need intensive care unit follow-up or non-invasive mechanical ventilation support. After a discharge and two weeks following the positive swab test result, patients were considered eligible if they had any symptoms. Transthoracic echocardiography (TTE) was performed within 24 h prior to CMRI. The median value of AST/ALT ratio was found, and the study population was divided into two subgroups based on the median AST/ALT ratio value. The clinical features, blood test, TTE and CMRI results were compared between subgroups. Results: C-reactive protein, D-dimer and fibrinogen were found to be significantly higher in patients with high AST/ALT ratio. LVEF, TAPSE, S', and FAC were significantly lower in patients with high AST/ALT ratio. LV-GLS were significantly lower in patients with high AST/ALT ratio. In CMRI, native T1 mapping signal, native T2 mapping signal and extracellular volume raised significantly in patients with high AST/ALT ratio. Right ventricle stroke volume and right ventricle ejection fraction were significantly lower in patients with high AST/ALT ratio, but right ventricle end systolic volume was significantly higher in patients with high AST/ALT ratio. Conclusion: High AST/ALT ratio is related to impaired right ventricular function parameters with CMRI and echocardiography after recovery from acute COVID-19. Assessment of AST/ALT ratio at hospital admission may be used to assess the risk of cardiac involvement in COVID-19 disease, and these patients may require closer follow-up during and after the course of COVID-19.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue6
dc.description.openaccessgold, Green Published
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume59
dc.identifier.doi10.3390/medicina59061163
dc.identifier.eissn1648-9144
dc.identifier.issn1010-660X
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85163727902
dc.identifier.urihttps://doi.org/10.3390/medicina59061163
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26625
dc.identifier.wos1016338100001
dc.keywordsCOVID 19
dc.keywordsAST
dc.keywordsALT ratio
dc.keywordsDe ritis ratio
dc.keywordsCardiac magnetic resonance imaging
dc.keywordsCardiac imaging
dc.keywordsSpeckle tracking echocardiography
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofMedicina-Lithuania
dc.subjectMedicine
dc.titleHigh AST/ALT ratio is associated with cardiac involvement in acute COVID-19 patients
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorÖzkök, Serçin
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit2Graduate School of Sciences and Engineering
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