Publication:
Thrombotic microangiopathy in the renal allograft: results of the TMA Banff working group consensus on pathologic diagnostic criteria

dc.contributor.coauthorAfrouzian, Marjan
dc.contributor.coauthorKozakowski, Nicolas
dc.contributor.coauthorLiapis, Helen
dc.contributor.coauthorBroecker, Verena
dc.contributor.coauthorTruong, Luon
dc.contributor.coauthorAvila-Casado, Carmen
dc.contributor.coauthorRegele, Heinz
dc.contributor.coauthorSeshan, Surya
dc.contributor.coauthorAmbruzs, Josephine M.
dc.contributor.coauthorFarris, Alton Brad
dc.contributor.coauthorBuob, David
dc.contributor.coauthorChander, Praveen N.
dc.contributor.coauthorCheraghvandi, Lukman
dc.contributor.coauthorClahsen-van Groningen, Marian C.
dc.contributor.coauthorAraujo, Stanley de Almeida
dc.contributor.coauthorFormby, Mark
dc.contributor.coauthorLjubanovic, Danica Galesic
dc.contributor.coauthorHernandez, Loren Herrera
dc.contributor.coauthorHonsova, Eva
dc.contributor.coauthorMohamed, Nasreen
dc.contributor.coauthorOzluk, Yasemin
dc.contributor.coauthorRabant, Marion
dc.contributor.coauthorRoyal, Virginie
dc.contributor.coauthorStevenson, Heather L.
dc.contributor.coauthorToniolo, Maria Fernanda
dc.contributor.coauthorTaheri, Diana
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBaydar, Dilek Ertoy
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:30:49Z
dc.date.issued2023
dc.description.abstractThe Banff community summoned the TMA Banff Working Group to develop minimum diagnostic criteria (MDC) and recommendations for renal transplant TMA (Tx-TMA) diagnosis, which currently lacks standardized criteria. Using the Delphi method for consensus generation, 23 nephropathologists (panelists) with >3 years of diagnostic experience with Tx-TMA were asked to list light, immunofluorescence, and electron microscopic, clinical and laboratory criteria and differential diagnoses for Tx-TMA. Delphi was modified to include 2 validations rounds with histological evaluation of whole slide images of 37 transplant biopsies (28 TMA and 9 non-TMA). Starting with 338 criteria in R1, MDC were narrowed down to 24 in R8 generating 18 pathological, 2 clinical, 4 laboratory criteria, and 8 differential diagnoses. The panelists reached a good level of agreement (70%) on 76% of the validated cases. For the first time in Banff classification, Delphi was used to reach consensus on MDC for Tx-TMA. Phase I of the study (pathology phase) will be used as a model for Phase II (nephrology phase) for consensus regarding clinical and laboratory criteria. Eventually in Phase III (consensus of the consensus groups) and the final MDC for Tx-TMA will be reported to the transplantation community.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessGreen Published, gold
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThis study was performed under the auspices of the Banff Foundation on Allograft Pathology and supported by grants from the Banff Foundation (for publication fees) and Alexion Pharmaceuticals (#100288). The funders were not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.r This study was performed under the auspices of the Banff Foundation on Allograft Pathology and supported by grants from the Banff Foundation (for publication fees) and Alexion Pharmaceuticals (#100288). The funders were not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.
dc.description.volume36
dc.identifier.doi10.3389/ti.2023.11590
dc.identifier.eissn1432-2277
dc.identifier.issn0934-0874
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85169883444
dc.identifier.urihttps://doi.org/10.3389/ti.2023.11590
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26128
dc.identifier.wos1069995300001
dc.keywordsThrombotic microangiopathy
dc.keywordsKidney
dc.keywordsTransplant
dc.keywordsPathology criteria
dc.keywordsDelphi
dc.keywordsBanff
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.grantnoThis study was performed under the auspices of the Banff Foundation on Allograft Pathology and supported by grants from the Banff Foundation (for publication fees) and Alexion Pharmaceuticals (#100288). The funders were not involved in the study design, co; Banff Foundation on Allograft Pathology; Banff Foundation [100288]; Alexion Pharmaceuticals
dc.relation.ispartofTransplant International
dc.subjectSurgery
dc.subjectTransplantation
dc.titleThrombotic microangiopathy in the renal allograft: results of the TMA Banff working group consensus on pathologic diagnostic criteria
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorBaydar, Dilek Ertoy
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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