Publication:
An update review of post-transplant diabetes mellitus: concept, risk factors, clinical implications and management

dc.contributor.coauthorGaipov, Abduzhappar
dc.contributor.coauthorFerro, Charles
dc.contributor.coauthorCozzolino, Mario
dc.contributor.coauthorCherney, David Z. I.
dc.contributor.coauthorTuttle, Katherine R.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuauthorTopçu, Ahmet Umur
dc.contributor.kuauthorGüldan, Mustafa
dc.contributor.kuauthorÇöpür, Sidar
dc.contributor.kuauthorÖzbek, Laşin
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:31:59Z
dc.date.issued2024
dc.description.abstractObjectiveKidney transplantation is the gold standard therapeutic alternative for patients with end-stage renal disease; nevertheless, it is not without potential complications leading to considerable morbidity and mortality such as post-transplant diabetes mellitus (PTDM). This narrative review aims to comprehensively evaluate PTDM in terms of its diagnostic approach, underlying pathophysiological pathways, epidemiological data, and management strategies.MethodsArticles were retrieved from electronic databases using predefined search terms. Inclusion criteria encompassed studies investigating PTDM diagnosis, pathophysiology, epidemiology, and management strategies.ResultsPTDM emerges as a significant complication following kidney transplantation, influenced by various pathophysiological factors including peripheral insulin resistance, immunosuppressive medications, infections, and proinflammatory pathways. Despite discrepancies in prevalence estimates, PTDM poses substantial challenges to transplant. Diagnostic approaches, including traditional criteria such as fasting plasma glucose (FPG) and HbA1c, are limited in their ability to capture early PTDM manifestations. Oral glucose tolerance test (OGTT) emerges as a valuable tool, particularly in the early post-transplant period. Management strategies for PTDM remain unclear, within sufficient evidence from large-scale randomized clinical trials to guide optimal interventions. Nevertheless, glucose-lowering agents and life style modifications constitute primary modalities for managing hyperglycemia in transplant recipients.DiscussionThe complex interplay between PTDM and the transplant process necessitates individualized diagnostic and management approaches. While early recognition and intervention are paramount, modifications to maintenance immunosuppressive regimens based solely on PTDM risk are not warranted, given the potential adverse consequences such as increased rejection risk. Further research is essential to refine management strategies and enhance outcomes for transplant recipients.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue7
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume26
dc.identifier.doi10.1111/dom.15575
dc.identifier.eissn1463-1326
dc.identifier.issn1462-8902
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85189624166
dc.identifier.urihttps://doi.org/10.1111/dom.15575
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26338
dc.identifier.wos1194229400001
dc.keywordsDiabetes mellitus
dc.keywordsGlucose-lowering drugs
dc.keywordsImmunosuppression
dc.keywordsSolid organ transplantation
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofDiabetes Obesity and Metabolism
dc.subjectMedicine
dc.titleAn update review of post-transplant diabetes mellitus: concept, risk factors, clinical implications and management
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorKanbay, Mehmet
local.contributor.kuauthorÇöpür, Sidar
local.contributor.kuauthorTopçu, Ahmet Umur
local.contributor.kuauthorGüldan, Mustafa
local.contributor.kuauthorÖzbek, Laşin
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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