Publication:
Age-related changes in epilepsy characteristics and response to antiepileptic treatment in autism spectrum disorders

dc.contributor.coauthorGaitanis, John
dc.contributor.coauthorAdams, James B.
dc.contributor.coauthorRossignol, Daniel A.
dc.contributor.coauthorFrye, Richard E.
dc.contributor.departmentDepartment of Psychology
dc.contributor.kuauthorGündoğdu, Beliz Su
dc.contributor.schoolcollegeinstituteCollege of Social Sciences and Humanities
dc.date.accessioned2025-01-19T10:31:14Z
dc.date.issued2023
dc.description.abstractDespite the high prevalence of epilepsy in individuals with autism spectrum disorder (ASD), there is little information regarding whether seizure characteristics and treatment effectiveness change across age. Using an online survey, seizure characteristics, effectiveness of antiepileptic treatments, comorbidities, potential etiologies, and ASD diagnosis were collected from individuals with ASD and seizures. We previously reported overall general patterns of treatment effectiveness but did not examine the effect of seizure characteristics or age on antiepileptic treatment effectiveness. Such information would improve the personalized medicine approach to the treatment of seizures in ASD. Survey data from 570 individuals with ASD and clinical seizures were analyzed. Seizure severity (seizure/week) decreased with age of onset of seizures, plateauing in adolescence, with a greater reduction in generalized tonic-clonic (GTC) seizures with age. Seizure severity was worse in those with genetic disorders, neurodevelopmental regression (NDR) and poor sleep maintenance. Carbamazepine and oxcarbazepine were reported to be more effective when seizures started in later childhood, while surgery and the Atkins/modified Atkins Diet (A/MAD) were reported to be more effective when seizures started early in life. A/MAD and the ketogenic diet were reported to be more effective in those with NDR. Interestingly, atypical Landau-Kleffner syndrome was associated with mitochondrial dysfunction and NDR, suggesting a novel syndrome. These interesting findings need to be verified in independent, prospectively collected cohorts, but nonetheless, these data provide insights into novel relationships that may assist in a better understanding of epilepsy in ASD and provide insight into personalizing epilepsy care in ASD.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue7
dc.description.openaccessgold, Green Submitted, Green Published
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume13
dc.identifier.doi10.3390/jpm13071167
dc.identifier.eissn2075-4426
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85166316330
dc.identifier.urihttps://doi.org/10.3390/jpm13071167
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26197
dc.identifier.wos1035873900001
dc.keywordsAntiepileptic drugs
dc.keywordsAge
dc.keywordsAutism spectrum disorder
dc.keywordsEpilepsy
dc.keywordsKetogenic diet
dc.keywordsMitochondrial dysfunction
dc.keywordsModified atkins diet
dc.keywordsNeurodevelopmental regression
dc.keywordsSeizures
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofJournal of Personalized Medicine
dc.subjectHealth care sciences
dc.subjectMedicine
dc.titleAge-related changes in epilepsy characteristics and response to antiepileptic treatment in autism spectrum disorders
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorGündoğdu, Beliz Su
local.publication.orgunit1College of Social Sciences and Humanities
local.publication.orgunit2Department of Psychology
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