Publication:
Physical mechanisms of emerging neuromodulation modalities

dc.contributor.departmentDepartment of Electrical and Electronics Engineering
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorHan, Mertcan
dc.contributor.kuauthorKaramürsel, Sacit
dc.contributor.kuauthorNizamoğlu, Sedat
dc.contributor.kuauthorErdoğan, Ezgi Tuna
dc.contributor.kuauthorKaratüm, Onuralp
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:32:19Z
dc.date.issued2023
dc.description.abstractOne of the ultimate goals of neurostimulation field is to design materials, devices and systems that can simultaneously achieve safe, effective and tether-free operation. For that, understanding the working mechanisms and potential applicability of neurostimulation techniques is important to develop noninvasive, enhanced, and multi-modal control of neural activity. Here, we review direct and transduction-based neurostimulation techniques by discussing their interaction mechanisms with neurons via electrical, mechanical, and thermal means. We show how each technique targets modulation of specific ion channels (e.g. voltage-gated, mechanosensitive, heat-sensitive) by exploiting fundamental wave properties (e.g. interference) or engineering nanomaterial-based systems for efficient energy transduction. Overall, our review provides a detailed mechanistic understanding of neurostimulation techniques together with their applications to in vitro, in vivo, and translational studies to guide the researchers toward developing more advanced systems in terms of noninvasiveness, spatiotemporal resolution, and clinical applicability.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.openaccesshybrid
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipS N acknowledges funding from the European Research Council (ERC, MESHOPTO, 101045289). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them. S N also acknowledges the Scientific and Technological Research Council of Turkey (TUBITAK) with Project Nos. 121C301, 120E329, and 121E376.
dc.description.volume20
dc.identifier.doi10.1088/1741-2552/acd870
dc.identifier.eissn1741-2552
dc.identifier.issn1741-2560
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85162255493
dc.identifier.urihttps://doi.org/10.1088/1741-2552/acd870
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26378
dc.identifier.wos1003892700001
dc.keywordsNeuromodulation
dc.keywordsNeural stimulation
dc.keywordsBiointerface
dc.keywordsNeural interface
dc.keywordsElectrical stimulation
dc.language.isoeng
dc.publisherIOP Publishing Ltd
dc.relation.grantnoEuropean Research Council (ERC) [101045289]; Scientific and Technological Research Council of Turkey (TUBITAK) [121C301, 120E329, 121E376]; European Research Council (ERC) [101045289] Funding Source: European Research Council (ERC)
dc.relation.ispartofJournal of Neural Engineering
dc.subjectEngineering
dc.subjectBiomedical
dc.subjectNeurosciences
dc.titlePhysical mechanisms of emerging neuromodulation modalities
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorKaratüm, Onuralp
local.contributor.kuauthorHan, Mertcan
local.contributor.kuauthorErdoğan, Ezgi Tuna
local.contributor.kuauthorKaramürsel, Sacit
local.contributor.kuauthorNizamoğlu, Sedat
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1College of Engineering
local.publication.orgunit2Department of Electrical and Electronics Engineering
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Sciences and Engineering
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