Publication:
The advanced hybrid closed loop improves glycemia risk index, continuous glucose monitoring index, and time in range in children with type 1 diabetes: real-world data from a single center study

dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorGökçe, Tuğba
dc.contributor.kuauthorMuradoğlu, Serra Küpçüoğlu
dc.contributor.kuauthorEviz, Elif
dc.contributor.kuauthorKarakuş, Kağan Ege
dc.contributor.kuauthorCan, Ecem
dc.contributor.kuauthorHatun, Şükrü
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:30:57Z
dc.date.issued2023
dc.description.abstractIntroduction: The Glycemia Risk Index (GRI) and Continuous Glucose Monitoring Index (COGI) are newly defined composite metric parameters derived from continuous glucose monitoring (CGM) data. GRI is divided into five separate risk zones (from lowest to highest: A-E). In this study, the effect of the advanced hybrid closed loop (AHCL) system on GRI and COGI in children with type 1 diabetes was evaluated. Materials and Methods: Forty-five children who had started using the AHCL and whose baseline and sixth-month CGM data were available were analyzed in terms of achievement of CGM consensus goals and changes in GRI scores and zones. The paired t-test was used for the analyses. Results: The mean age and duration of diabetes of the participants were 10.95 +/- 3.41 and 3.85 +/- 2.67 years, respectively. The mean GRI score significantly decreased from 35.66 +/- 17.46 at baseline to 22.83 +/- 9.08 at 6 months (P < 0.001). Although the proportion of those in the A zone was 20% at baseline, it increased to 42% at 6 months. AHCL also improved COGI from 72.59 +/- 12.44 to 82.90 +/- 7.72 (P < 0.001). Time in range (TIR) increased significantly from 70.54% to 80.51% (P < 0.001) at 6 months. Conclusion: AHCL provides not only an improvement in TIR but also a significant improvement in both GRI and COGI at 6 months. The incorporation of GRI and COGI alongside TIR may enhance the assessment of the glycemic profile by providing a more comprehensive and in-depth analysis.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue10
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume25
dc.identifier.doi10.1089/dia.2023.0112
dc.identifier.eissn1557-8593
dc.identifier.issn1520-9156
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85171997832
dc.identifier.urihttps://doi.org/10.1089/dia.2023.0112
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26154
dc.identifier.wos1084972000002
dc.keywordsAdvanced hybrid closed loop system
dc.keywordsGlycemia Risk Index
dc.keywordsHypoglycemia component
dc.keywordsHyperglycemia component
dc.keywordsType 1 diabetes
dc.language.isoeng
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofDiabetes Technology and Therapeutics
dc.subjectEndocrinology and metabolism
dc.titleThe advanced hybrid closed loop improves glycemia risk index, continuous glucose monitoring index, and time in range in children with type 1 diabetes: real-world data from a single center study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorEviz, Elif
local.contributor.kuauthorKarakuş, Kağan Ege
local.contributor.kuauthorMutlu, Rahime Gül Yeşiltepe
local.contributor.kuauthorCan, Ecem
local.contributor.kuauthorGökçe, Tuğba
local.contributor.kuauthorMuradoğlu, Serra Küpçüoğlu
local.contributor.kuauthorHatun, Şükrü
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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