Publication:
Pancreatic steatosis is an independent risk factor for post-transplant diabetes mellitus in kidney transplant patients

dc.contributor.coauthorSiriopol, Dimitrie (55135889900
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuauthorHasbal, Nuri Barış
dc.contributor.kuauthorPeltek, İbrahim Batuhan
dc.contributor.kuauthorAtalay, Hande Özen
dc.contributor.kuauthorKarakaya, Afak Durur
dc.contributor.kuauthorKesgin, Yavuz Erkam
dc.contributor.kuauthorMutlu, Ali
dc.contributor.kuauthorÇöpür, Sidar
dc.contributor.kuauthorKoçak, Burak
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:31:28Z
dc.date.issued2023
dc.description.abstractBackground and Aim: Post-transplant diabetes mellitus (PTDM) is associated with an increased risk of post-transplant cardiovascular diseases, and several risk factors of PTDM have been shown in the literature. Yet, the relationship between hepatic and pancreatic steatosis with post-transplant diabetes mellitus remains vague. We aimed to evaluate pancreatic steatosis, a novel component of metabolic syndrome, and hepatic steatosis association with post-transplant diabetes mellitus in a single-center retrospective cohort study conducted on kidney transplant recipients.Method: We have performed a single-center retrospective cohort study involving all kidney transplant recipients. We have utilized pretransplant Fibrosis-4, nonalcoholic fatty liver disease fibrosis score, and abdominal computed tomography for the assessment of visceral steatosis status.Results: We have included 373 kidney transplant recipients with a mean follow-up period of 32 months in our final analysis. Post-transplant diabetes mellitus risk is associated with older age (p < .001), higher body-mass index (p < .001), nonalcoholic fatty liver disease-fibrosis score (p = .002), hepatic (p < .001) or pancreatic (p < .001) steatosis on imaging and higher pre-transplant serum triglyceride (p = .003) and glucose levels (p = .001) after multivariate analysis.Conclusion: Our study illustrates that recipients' pancreatic steatosis is an independent predictive factor for post-transplant diabetes mellitus including in kidney transplant patients.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume38
dc.identifier.doi10.1111/ctr.15204
dc.identifier.eissn1399-0012
dc.identifier.issn0902-0063
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85178395569
dc.identifier.urihttps://doi.org/10.1111/ctr.15204
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26251
dc.identifier.wos1112537600001
dc.keywordsKidney transplantation
dc.keywordsNon-alcoholic fatty liver
dc.keywordsPancreatic steatosis
dc.keywordsPost-transplant diabetes mellitus
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofClinical Transplantation
dc.subjectSurgery
dc.subjectTransplantation
dc.subjectMedicine
dc.titlePancreatic steatosis is an independent risk factor for post-transplant diabetes mellitus in kidney transplant patients
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorHasbal, Nuri Barış
local.contributor.kuauthorKanbay, Mehmet
local.contributor.kuauthorÇöpür, Sidar
local.contributor.kuauthorPeltek, İbrahim Batuhan
local.contributor.kuauthorMutlu, Ali
local.contributor.kuauthorAtalay, Hande Özen
local.contributor.kuauthorKesgin, Yavuz Erkam
local.contributor.kuauthorKarakaya, Afak Durur
local.contributor.kuauthorKoçak, Burak
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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