Publication:
A first-in-human pilot study of a novel electrically-passive metamaterial-inspired resonator-based ocular sensor embedded contact lens monitoring intraocular pressure fluctuations

dc.contributor.coauthorKaya, Ozgur
dc.contributor.coauthorAkif Aydin, M.
dc.contributor.coauthorTeymoori, Morteza
dc.contributor.coauthorKaan Erden, Oguz
dc.contributor.coauthorSadeghzadeh, Seyedehayda
dc.contributor.coauthorDedeoglu, Ulas O.
dc.contributor.coauthorDemir, Saibe
dc.contributor.coauthorMuhikanci, Omer
dc.contributor.coauthorTorun, Hamdi
dc.contributor.coauthorDundar, Gunhan
dc.contributor.coauthorYalcinkaya, Arda D.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorŞahin, Afsun
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:34:03Z
dc.date.issued2023
dc.description.abstractGlaucoma is a leading cause of blindness with no cure, but early treatment and effective monitoring can often slow the progression of the disease. Monitoring of glaucoma is based on the measurement of intra-ocular pressure (IOP) that is a physiological parameter related to the mechanical state and parameters of the eye. Conventionally, diagnosing and assessing the progression of glaucoma is based on the method of measuring IOP discretely at clinics. Recent studies have demonstrated the importance of continuously monitoring IOP for 24 h to elucidate the effect of circadian rhythm. In this work, a metamaterial-inspired electrically-passive sensor-embedded contact lens is presented to monitor the IOP fluctuations based on a first-in-human pilot study. The sensor inside the contact lens is an electrically passive, metamaterial-based resonator that can be measured using a wearable antenna patch. The system has been tested with six healthy volunteers during an experiment to induce deliberate IOP changes via water-loading and placing the individuals in supine position using a recliner seat. The initial data compared with tonometer measurements suggest that the system can be used to assess the variation of IOP continuously. © 2023 The Author(s)
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessAll Open Access; Hybrid Gold Open Access
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume47
dc.identifier.doi10.1016/j.clae.2023.102102
dc.identifier.eissn1476-5411
dc.identifier.issn13670484
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85180589970
dc.identifier.urihttps://doi.org/10.1016/j.clae.2023.102102
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26718
dc.identifier.wos1222593300001
dc.keywordsDiagnostics
dc.keywordsGlaucoma
dc.keywordsSensors
dc.keywordsSmart contact lens
dc.keywordsWearables
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofContact Lens and Anterior Eye
dc.subjectMedicine
dc.titleA first-in-human pilot study of a novel electrically-passive metamaterial-inspired resonator-based ocular sensor embedded contact lens monitoring intraocular pressure fluctuations
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorŞahin, Afsun
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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