Publication:
Immunosuppression of HLA identical living-donor kidney transplant recipients: a systematic review

dc.contributor.coauthorPerez-Saez, Maria Jose
dc.contributor.coauthorMontero, Nuria
dc.contributor.coauthorOliveras, Laia
dc.contributor.coauthorRedondo-Pachon, Dolores
dc.contributor.coauthorMartinez-Simon, David
dc.contributor.coauthorAbramovicz, Daniel
dc.contributor.coauthorMaggiore, Umberto
dc.contributor.coauthorMariat, Christophe
dc.contributor.coauthorMjoen, Geir
dc.contributor.coauthorOniscu, Gabriel C.
dc.contributor.coauthorPeruzzi, Licia
dc.contributor.coauthorSeveri, Mehmet Sukru
dc.contributor.coauthorWatschingerj, Bruno
dc.contributor.coauthorVelioglu, Arzu
dc.contributor.coauthorGandolfini, Ilaria
dc.contributor.coauthorHellemans, Rachel
dc.contributor.coauthorHilbrands, Luuk
dc.contributor.coauthorPascual, Julio
dc.contributor.coauthorCrespo, Marta
dc.contributor.departmentTIREX (Koç University Transplant Immunology Research Centre of Excellence)
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.kuauthorDemir, Erol
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2025-01-19T10:30:09Z
dc.date.issued2023
dc.description.abstractBackground: Kidney transplant (KT) recipients of HLA identical siblings (HLAid) have lower immunological risk, but there are no specific recommendations for immunosuppression. Our aim was to analyze evidence about results from HLAid living-donor recipients under different immunosuppression in the current era of immunological risk assessment. Methods: Systematic review of studies describing associations between outcomes of HLAid living-donor KT recipients according to their immunological risk and applied immunosuppression. Results: From 1351 studies, 16 (5636 KT recipients) were included in the analysis. All studies were retrospective, ten comparing immunosuppression strategies, and six immunological risk strata. Of those ten, six studies were published in 1990 or earlier and only three included tacrolimus. The evidence is poor, and the inclusion of calcineurin inhibitors does not demonstrate better results. Furthermore, only few studies describe different immunosuppression regimens according to the patient immunological risk and, in general, they do not include the assessment with new solid phase assays. Conclusions: There are no studies analyzing the association of outcomes of HLAid KT recipients with current immunological risk tools. In the absence of evidence, no decision or proposal of immunosuppression adapted to modern immunological risk assessment can be made currently by the Descartes Working Group.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue4
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipMJPS has been granted by the Spanish Society of Transplant. This study was performed with funding from projects PI16/00617, PI19/00037 and PI20/00090 (Spanish Ministry of Health ISCIII FIS-FEDER) and RD16/0009/0013 (ISCIII FEDER REDinREN) .
dc.description.volume37
dc.identifier.doi10.1016/j.trre.2023.100787
dc.identifier.issn0955-470X
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85168820571
dc.identifier.urihttps://doi.org/10.1016/j.trre.2023.100787
dc.identifier.urihttps://hdl.handle.net/20.500.14288/25994
dc.identifier.wos1118632000001
dc.keywordsLiving kidney donation
dc.keywordsHLA-identical siblings
dc.keywordsImmunosuppression
dc.keywordsImmunological risk
dc.keywordsSingle HLA antigen beads
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.grantnoSpanish Society of Transplant; Spanish Ministry of Health ISCIII FIS-FEDER [PI16/00617, PI19/00037, PI20/00090]; ISCIII FEDER REDinREN [RD16/0009/0013]
dc.relation.ispartofTransplantation Reviews
dc.subjectImmunology
dc.subjectTransplantation
dc.titleImmunosuppression of HLA identical living-donor kidney transplant recipients: a systematic review
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorDemir, Erol
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1Research Center
local.publication.orgunit2TIREX (Koç University Transplant Immunology Research Centre of Excellence)
local.publication.orgunit2Graduate School of Health Sciences
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