Publication:
Is there any robust evidence showing that SGLT2 inhibitor predisposes to cancer?

dc.contributor.coauthorCovic, Adrian
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuauthorYıldız, Abdullah Burak
dc.contributor.kuauthorÇöpür, Sidar
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:30:06Z
dc.date.issued2023
dc.description.abstractBackground: The exact pathophysiological mechanisms of SGLT-2 inhibitors in the development, progression or treatment of malignancies are not fully understood, but multiple hypotheses have been proposed. SGLT-2 inhibitors have potential anti-proliferative roles due to several underlying pathophysiological mechanisms, such as inhibition of ATP production, activation of AMPK signalling, induction of apoptosis and ferroptosis, inhibition of glutamate dehydrogenase activity and inhibition of DNA and RNA synthesis. However, heterogeneity among tumour cells and SGLT-2 inhibitor drugs limit the generalizability of pre-clinical studies.Methods: This is a narrative review discussing the potential anti-cancer effects of SGLT-2 inhibitors, an oral glucose-lowering medication used in patients with type II diabetes mellitus. This review discusses underlying mechanisms, pre-clinical and clinical trial data, epidemiological data and future perspectives on the use of SGLT-2 inhibitors in cancer treatment.Results: Type II diabetes is linked to various comorbidities and malignancies, but some glucose-slowering medications may have a preventive role in cancer. The use of SGLT-2 inhibitors was associated with bladder cancer based on mice studies. However, meta-analyses showed no significant increase in overall malignancy incidence of any specific type, except for empagliflozin and bladder cancer association. SGLT-2 inhibitors can potentially reduce the heart damage caused by doxorubicin and sunitinib, while enhancing the anti-cancer effects of doxorubicin. Combining SGLT-2 inhibitors with doxorubicin may allow higher doses of chemotherapy use. Multiple ongoing clinical trials are investigating the potential therapeutic potential of SGLT-2 inhibitors in various types of cancer.Conclusion: More large-scale pre-clinical and clinical studies are needed to explore their potential preventive and therapeutic roles of SGLT-2 inhibitors in cancer treatment. In this narrative review, our aim is to explore the pre-clinical and clinical data regarding the potential anti-cancer effects of SGLT-2 inhibitors including the hypothetical pathophysiological mechanisms.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessBronze
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume54
dc.identifier.doi10.1111/eci.14131
dc.identifier.eissn1365-2362
dc.identifier.issn0014-2972
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85177823946
dc.identifier.urihttps://doi.org/10.1111/eci.14131
dc.identifier.urihttps://hdl.handle.net/20.500.14288/25978
dc.identifier.wos1109794900001
dc.keywordsCanagliflozin
dc.keywordsCancer
dc.keywordsDapagliflozin
dc.keywordsEmpagliflozin
dc.keywordsSGLT2 inhibitors
dc.keywordsUrinary bladder cancer
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofEuropean Journal of Clinical Investigation
dc.subjectMedicine, general and internal
dc.titleIs there any robust evidence showing that SGLT2 inhibitor predisposes to cancer?
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorÇöpür, Sidar
local.contributor.kuauthorKanbay, Mehmet
local.contributor.kuauthorYıldız, Abdullah Burak
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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