Publications without Fulltext
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
Browse
5870 results
Search Results
Publication Metadata only Targeting cancer cells via tumor-homing peptide CREKA functional PEG nanoparticles(Elsevier, 2016) N/A; N/A; N/A; Department of Chemical and Biological Engineering; Okur, Aysu Ceren; Erkoç, Pelin; Kızılel, Seda; Master Student; PhD Student; Faculty Member; Department of Chemical and Biological Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; N/A; 28376Targeting cell microenvironment via nano-particle based therapies holds great promise for treatment of various diseases. One of the main challenges in targeted delivery of nanoparticles for cancer therapy includes reduced localization of delivery vehicles at tumor site. The therapeutic efficacy of drugs can be improved by recruiting delivery vehicles towards specific region of tumorigenesis in the body. Here, we demonstrate an effective approach in creating PEG particles via water-in-water emulsion technique where tumor-homing peptide CREKA was used for functionalization. Simultaneous conjugation of laminin peptide IKVAV into hydrogel network and influence of altered combinations of ligands on intracellular uptake of anticancer drugs by HeLa cells were investigated. CREKA conjugated hydrogel nanoparticles were more effective to improve apoptotic effects of the model drug Doxorubicin (DOX) compared to that of particles conjugated with other peptides. Fluorescence intensity analysis on confocal micrographs suggested significantly higher cellular uptake of CREKA conjugated PEG particles than internalization of nanoparticles in other groups. We observed that fibrin binding ability of PEG particles could be increased up to 94% through CREKA conjugation. Our results suggest the possibility of cancer cell targeting via CREKA-functional PEG nanoparticles.Publication Metadata only Effects of alprazolam and haloperidol on thyroglobulin, antithyroglobulin, anti thyroid peroxidase and TSH in Rat(Walter De Gruyter Gmbh, 2018) Samadi, Afshin; Ansari, Mohammad Hassan Khadem; Ulusu, Nuriye Nuray; Faculty Member; School of Medicine; 6807Background: A large number of psychotropic drugs can interfere with the thyroid physiology, function and autoimmunity. Objective: The aim of the present study was to investigate the effects of alprazolam and haloperidol on thyroglobulin, antithyroglobulin (aTg), antithyroid peroxidase, and thyroid stimulating hormone levels on rats. Materials and Methods: First group of adult male Wistar rats was the control, second group received 0.5 mg kg(-1) haloperidol in physiological saline and the third group received 0.5 mg kg(-1) alprazolam, via gastric gavage once daily for 28 days. Plasma levels of all thyroid function tests were measured with chemiluminescent assay. Results: We have investigated a decrease in aTg amounts of control group (5.461 +/- 0.718) compared with drug treated rats with alprazolam (1.433 +/- 0.225) and haloperidol (1.21 +/- 0.228). (P-aTg = 0.00([ALP]), P-aTg = 0.01([HAL])). Although there were not any change in thyroglobulin levels in the haloperidol treated groups (0.9583 +/- 0.014) relative to control group (0.975 +/- 0.015); but in opposition Tg levels decreased significantly in response to alprazolam (0.36 +/- 0.16) compared with the control group (0.975 +/- 0.015), p-values are (P-Tg = 0. 001([ALP])), (P-Tg = 0. 021([HAL])). Conclusion: We found that these two drugs may interfere with the thyroid physiology and metabolism.Publication Metadata only Trans-Atlantic equity volatility connectedness: U.S. and European financial institutions, 2004-2014(Oxford Univ Press, 2016) Diebold, Francis X.; Department of Economics; Yılmaz, Kamil; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 6111We characterize equity return volatility connectedness in the network of major American and European financial institutions, 2004-2014. Our methods enable precise characterization of the timing and evolution of key aspects of the financial crisis. First, we find that during 2007-2008 the direction of connectedness was clearly from the United States to Europe, but that connectedness became bidirectional starting in late 2008. Second, we find an unprecedented surge in directional connectedness from European to U.S. financial institutions in June 2011, consistent with massive deterioration in the health of EU financial institutions. Third, we identify particular institutions that played disproportionately important roles in generating connectedness during the U.S. and the European crises.Publication Metadata only Prophylactic cranial irradiation in small and non-small-cell lung carcinoma(Springer, 2016) Topkan, Erkan; N/A; Selek, Uğur; Faculty Member; School of Medicine; 27211At initial presentation, approximately 10–14 % of small-cell lung carcinoma (SCLC) patients manifest with radiologically evident brain metastases (BM) which arises up to 69 % at 2 years. Similarly, brain failures are reported in 21–54 % of all non-small-cell lung carcinoma (NSCLC) patients, and of these, the brain is the first site of relapse in 15–30 % cases. Although significant improvements have been achieved in local and distant control of both SCLC and NSCLC as a result of implementation of aggressive treatment modalities, unfortunately such aggressive treatments proved no noteworthy viability in lessening of overall brain or brain as the first site of relapse rates. Regarding its counteractive actions on BM emergence, the potential beneficial effects of prophylactic cranial irradiation (PCI) in patients with limited-stage SCLC (LS-SCLC), extensive-stage SCLC (ES-SCLC), and locally advanced NSCLC (LA-NSCLC) have been addressed with several randomized trials and meta-analysis. Based on the results of these investigations, PCI of 25 Gy (2.5 Gy in ten fractions) should be recommended for all medically fit LS- and ES-SCLC patients with any objective response to primary therapy in order to reduce BM incidence rates and to prolong OS times. Although the PCI studies in LA-NSCLC patients suggest significant reductions in BM incidence rates with PCI, yet in the absence of an established survival benefit, it is currently quite difficult to recommend its routine use in LA-NSCLC patients. However, future studies involving high-risk patients may prove worthy in determination of the exact impact if they are needed in order to reliably comment on the issue of PCI in LA-NSCLC patients.Publication Metadata only A resilient landscape: the land walls of constantinople and their surroundings(Christian Archaeological Soc, 2018) Department of Archeology and History of Art; Ricci, Alessandra; Faculty Member; Department of Archeology and History of Art; College of Social Sciences and Humanities; 41889The land walls of Constantinople, built in the early years of the 5th century, substantially reinforced the city's defenses while contributing to the creation of the capital's urban identity. This paper considers a rarely touched-upon subject, that of the usage of agricultural spaces within the land walls and their immediate vicinity. The presence of horticultural activities noted along present-day sections of the land walls represents the intangible memory of patterns of usage now traceable to the Late Antique period.Publication Metadata only Policy priorities in the election manifestos of political parties in Turkey, 2002-2015(İstanbul Üniversitesi, 2017) Department of International Relations; Aytaç, Selim Erdem; Faculty Member; Department of International Relations; College of Administrative Sciences and Economics; 224278The policy areas prioritized by the major Turkish political parties during the election campaigns between 2002 and 2015 are examined in this study. The main questions to be addressed are as follows: Which policy areas do the political parties prioritize? Is there a significant divergence in the prioritization of different policy areas or are there common themes that are emphasized by all parties? Are there trends regarding the parties’ policy priorities over time? and finally, do the policy areas, as prioritized by the parties, correspond to what the public considers as important issues? To address these questions, the election manifestos of the four major Turkish political parties are analyzed. The analyses show that policy areas related to the economy, welfare, and quality of life are the most recurring themes in the election manifestos of the four major Turkish parties between 2002 and 2015.Publication Metadata only Evolution of transformation plasticity in austenite-to-bainite phase transformation: a multi parameter problem(Elsevier Science Sa, 2012) Lambers, Hans -Gerd; Maier, Hans Jürgen; Department of Mechanical Engineering; Canadinç, Demircan; Faculty Member; Department of Mechanical Engineering; College of Engineering; 23433The current paper presents a thorough experimental analysis of the austenite-to-bainite phase transformation, and provides insight into microstructural changes associated with the observed transformation plasticity (TP). Specifically, the evolution of TP was studied in the presence of several parameters, namely pre-deformation, temperature and superimposed constant stresses, and the observed phenomena were linked to microstructural changes under these circumstances based on experimental data. One major finding is that the evolution of TP strains is governed both by the superimposed external stresses and the temperature dependence of internal stresses introduced by pre-deformation.Publication Metadata only Chiropractic alters TMS induced motor neuronal excitability: preliminary findings(Springer International Publishing Ag, 2014) Haavik, Heidi; Niazi, Imran Khan; Duehr, Jens; Kinget, Mat; Ugincius, Paulius; Department of Physics; N/A; Sebik, Oğuz; Yılmaz, Gizem; Türker, Kemal Sıtkı; Researcher; PhD Student; Faculty Member; Department of Physics; College of Sciences; Graduate School of Health Sciences; School of Medicine; Koç University Hospital; N/A; N/A; 6741The objective of this study was to use the electromyography (EMG) via surface and intramuscular single motor unit recordings to further characterize the immediate sensorimotor effects of spinal manipulation and a control intervention using TMS. The results provide evidence that spinal manipulation of dysfunctional spinal segments increases low threshold motoneurone excitability.Publication Metadata only Sequence of theory-of-mind acquisition in Turkish children from diverse social backgrounds(Wiley, 2018) Brink, Kimberly A.; Wellman, Henry M.; Department of Psychology; N/A; Selçuk, Bilge; Ekerim-Akbulut, Müge; Faculty Member; PhD Student; Department of Psychology; College of Social Sciences and Humanities; Graduate School of Social Sciences and Humanities; 52913; 311454We examined the sequence of theory of mind (ToM) acquisition in 260 Turkish children (M-age=53.36months, SD=10.37) and the demographic factors associated with it. Children came from 5 different cities in Turkey. Their ToM skills were measured using ToM Scale, which probes various mental state understandings from diverse desires to hidden emotions. These Turkish children demonstrated the traditional, collectivist ToM acquisition pattern evident in Iran and China with earlier understanding of knowledge access than diverse beliefs, not the western, individualist pattern evident in the United States, Australian, and German children. Gender, socio-economic status (SES), and number of adults living in the home influenced the pace of children's ToM acquisitions. A post hoc analysis examined a minority of children that exhibited individualist ToM acquisition with earlier achievement of diverse beliefs than knowledge access. The results contribute to a fuller sociocultural understanding of ToM development including examination of variations within a single heterogeneous developing country. They also further suggest the importance of exposure to different ideas and beliefs in large households for earlier understanding of varying belief states. Highlights We assessed theory of mind (ToM) acquisition in 260 Turkish children whose families spanned a large range of social class circumstances. We measured ToM via Wellman and Liu's scale (2004), consisting of five items testing diverse desires, diverse belief, knowledge access, false belief, and hidden emotion. The Turkish children demonstrated the traditional, collectivist ToM acquisition pattern, but a minority of children exhibited individualistic ToM acquisition. In cultures where elements of individualism and collectivism are blended, children can come to different orders of acquisition in accord with recent arguments that cultural development often represents a coexistence of different reasoning styles.Publication Metadata only Prognostic significance of metastatic lymph node ratio in patients with pN3 gastric cancer who underwent curative gastrectomy(Karger, 2019) Bilici, Ahmet; Şeker, Mesut; Öven, Basak B.; Ölmez, Ömer Fatih; Yıldız, Özcan; Ölmüşçelik, Oktay; Hamdard, Jamshid; Açıkgöz, Özgür; Çakır, Aslı; Öncel, Mustafa; Selçukbiricik, Fatih; Kapran, Yersu; Balık, Emre; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; 202015; 168101; 18758Background: Lymph node involvement is an important prognostic factor in patients with gastric cancer. The aim of this study was to determine the prognostic significance of metastatic lymph node ratio (MLNR) and compare it to the number of lymph node metastasis in pN3 gastric cancer. Methods: We retrospectively analyzed 207 patients with pN3 gastric cancer who had undergone radical gastrectomy. Prognostic factors and MLNR were evaluated by univariate and multivariate analysis. Results: An MLNR of 0.75 was found to be the best cut-off value to determine the prognosis of patients with pN3 gastric cancer (p = 0.001). The MLNR was significantly higher in patients with large-sized and undifferentiated tumors, vascular, lymphatic and perineural invasion, and total gastrectomy. In multivariate analysis, MLNR (p = 0.041), tumor differentiation (p = 0.046), and vascular invasion (p = 0.012) were found to be independent prognos-tic factors for disease-free survival, while both MLNR (p < 0.001) and pN stage (p = 0.002) were independent prognostic indicators, as was tumor size, for overall survival. There was significant difference with respect to the recurrence patterns between MLNR groups. Lymph node and peritoneal recurrences were significantly higher in patients with MLNR > 0.75 compared to the MLNR < 0.75 group (p < 0.05). However, recurrence patterns were similar between pN3a and pN3b. Conclusion: Our results showed that MLNR was a useful indicator to determine the prognosis and recurrence patterns of patients with radically resected gastric cancer. Moreover, MLNR is a beneficial and reliable technique for evaluating lymph node metastasis.