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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only Targeting cancer cells via tumor-homing peptide CREKA functional PEG nanoparticles(Elsevier, 2016) N/A; N/A; N/A; Department of Chemical and Biological Engineering; Okur, Aysu Ceren; Erkoç, Pelin; Kızılel, Seda; Master Student; PhD Student; Faculty Member; Department of Chemical and Biological Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; N/A; 28376Targeting cell microenvironment via nano-particle based therapies holds great promise for treatment of various diseases. One of the main challenges in targeted delivery of nanoparticles for cancer therapy includes reduced localization of delivery vehicles at tumor site. The therapeutic efficacy of drugs can be improved by recruiting delivery vehicles towards specific region of tumorigenesis in the body. Here, we demonstrate an effective approach in creating PEG particles via water-in-water emulsion technique where tumor-homing peptide CREKA was used for functionalization. Simultaneous conjugation of laminin peptide IKVAV into hydrogel network and influence of altered combinations of ligands on intracellular uptake of anticancer drugs by HeLa cells were investigated. CREKA conjugated hydrogel nanoparticles were more effective to improve apoptotic effects of the model drug Doxorubicin (DOX) compared to that of particles conjugated with other peptides. Fluorescence intensity analysis on confocal micrographs suggested significantly higher cellular uptake of CREKA conjugated PEG particles than internalization of nanoparticles in other groups. We observed that fibrin binding ability of PEG particles could be increased up to 94% through CREKA conjugation. Our results suggest the possibility of cancer cell targeting via CREKA-functional PEG nanoparticles.Publication Metadata only Prophylactic cranial irradiation in small and non-small-cell lung carcinoma(Springer, 2016) Topkan, Erkan; N/A; Selek, Uğur; Faculty Member; School of Medicine; 27211At initial presentation, approximately 10–14 % of small-cell lung carcinoma (SCLC) patients manifest with radiologically evident brain metastases (BM) which arises up to 69 % at 2 years. Similarly, brain failures are reported in 21–54 % of all non-small-cell lung carcinoma (NSCLC) patients, and of these, the brain is the first site of relapse in 15–30 % cases. Although significant improvements have been achieved in local and distant control of both SCLC and NSCLC as a result of implementation of aggressive treatment modalities, unfortunately such aggressive treatments proved no noteworthy viability in lessening of overall brain or brain as the first site of relapse rates. Regarding its counteractive actions on BM emergence, the potential beneficial effects of prophylactic cranial irradiation (PCI) in patients with limited-stage SCLC (LS-SCLC), extensive-stage SCLC (ES-SCLC), and locally advanced NSCLC (LA-NSCLC) have been addressed with several randomized trials and meta-analysis. Based on the results of these investigations, PCI of 25 Gy (2.5 Gy in ten fractions) should be recommended for all medically fit LS- and ES-SCLC patients with any objective response to primary therapy in order to reduce BM incidence rates and to prolong OS times. Although the PCI studies in LA-NSCLC patients suggest significant reductions in BM incidence rates with PCI, yet in the absence of an established survival benefit, it is currently quite difficult to recommend its routine use in LA-NSCLC patients. However, future studies involving high-risk patients may prove worthy in determination of the exact impact if they are needed in order to reliably comment on the issue of PCI in LA-NSCLC patients.Publication Metadata only Chiropractic alters TMS induced motor neuronal excitability: preliminary findings(Springer International Publishing Ag, 2014) Haavik, Heidi; Niazi, Imran Khan; Duehr, Jens; Kinget, Mat; Ugincius, Paulius; Department of Physics; N/A; Sebik, Oğuz; Yılmaz, Gizem; Türker, Kemal Sıtkı; Researcher; PhD Student; Faculty Member; Department of Physics; College of Sciences; Graduate School of Health Sciences; School of Medicine; Koç University Hospital; N/A; N/A; 6741The objective of this study was to use the electromyography (EMG) via surface and intramuscular single motor unit recordings to further characterize the immediate sensorimotor effects of spinal manipulation and a control intervention using TMS. The results provide evidence that spinal manipulation of dysfunctional spinal segments increases low threshold motoneurone excitability.Publication Metadata only Sequence of theory-of-mind acquisition in Turkish children from diverse social backgrounds(Wiley, 2018) Brink, Kimberly A.; Wellman, Henry M.; Department of Psychology; N/A; Selçuk, Bilge; Ekerim-Akbulut, Müge; Faculty Member; PhD Student; Department of Psychology; College of Social Sciences and Humanities; Graduate School of Social Sciences and Humanities; 52913; 311454We examined the sequence of theory of mind (ToM) acquisition in 260 Turkish children (M-age=53.36months, SD=10.37) and the demographic factors associated with it. Children came from 5 different cities in Turkey. Their ToM skills were measured using ToM Scale, which probes various mental state understandings from diverse desires to hidden emotions. These Turkish children demonstrated the traditional, collectivist ToM acquisition pattern evident in Iran and China with earlier understanding of knowledge access than diverse beliefs, not the western, individualist pattern evident in the United States, Australian, and German children. Gender, socio-economic status (SES), and number of adults living in the home influenced the pace of children's ToM acquisitions. A post hoc analysis examined a minority of children that exhibited individualist ToM acquisition with earlier achievement of diverse beliefs than knowledge access. The results contribute to a fuller sociocultural understanding of ToM development including examination of variations within a single heterogeneous developing country. They also further suggest the importance of exposure to different ideas and beliefs in large households for earlier understanding of varying belief states. Highlights We assessed theory of mind (ToM) acquisition in 260 Turkish children whose families spanned a large range of social class circumstances. We measured ToM via Wellman and Liu's scale (2004), consisting of five items testing diverse desires, diverse belief, knowledge access, false belief, and hidden emotion. The Turkish children demonstrated the traditional, collectivist ToM acquisition pattern, but a minority of children exhibited individualistic ToM acquisition. In cultures where elements of individualism and collectivism are blended, children can come to different orders of acquisition in accord with recent arguments that cultural development often represents a coexistence of different reasoning styles.Publication Metadata only Enhancement of throat microphone recordings by learning phone-dependent mappings of speech spectra(Institute of Electrical and Electronics Engineers (IEEE), 2013) N/A; Department of Computer Engineering; Turan, Mehmet Ali Tuğtekin; Erzin, Engin; PhD Student; Faculty Member; Department of Computer Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; 34503We investigate spectral envelope mapping problem with joint analysis of throat- and acoustic-microphone recordings to enhance throatmicrophone speech. A new phone-dependent GMM-based spectral envelope mapping scheme, which performs the minimum mean square error (MMSE) estimation of the acoustic-microphone spectral envelope, has been proposed. Experimental evaluations are performed to compare the proposed mapping scheme to the state-of-theart GMM-based estimator using both objective and subjective evaluations. Objective evaluations are performed with the log-spectral distortion (LSD) and the wideband perceptual evaluation of speech quality (PESQ) metrics. Subjective evaluations are performed with the A/B pair comparison listening test. Both objective and subjective evaluations yield that the proposed phone-dependent mapping consistently improves performances over the state-of-the-art GMM estimator.Publication Metadata only 2.3-μm Tm3+: YLF laser passively Q-switched with a Cr2+: ZnSe saturable absorber(Optical Soc Amer, 2017) N/A; N/A; Canbaz, Ferda; Yorulmaz, İsmail; Sennaroğlu, Alphan; PhD Student; PhD Student; Faculty Member; Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM); Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Sciences; N/A; N/A; 23851We report, what is to our knowledge, the first passively Q-switched operation of a 2.3-mu m Tm3+ : YLF laser by using a Cr2+ : ZnSe saturable absorber. In the experiments, a tunable Ti3+ : sapphire laser was used to end pump the Tm3+ : YLF gain medium inside an x cavity. A Cr2+ : ZnSe saturable absorber was also included in the cavity to initiate passive Q switching. At all pump power levels above lasing threshold, passively Q-switched operation of the Tm3+ : YLF laser could be obtained at 2309 nm with pulse durations and repetition frequencies in the ranges of 1.21.4 mu s and 0.3-2.1 kHz, respectively. Analysis of power dependent repetition rate data further gave an estimated value of 3.1% for the round-trip saturable loss of the Cr2+ : ZnSe saturable absorber.Publication Metadata only Exploring projection based mixed reality with tangibles for nonsymbolic preschool math education(Assoc Computing Machinery, 2019) N/A; N/A; Department of Psychology; Department of Media and Visual Arts; Department of Electrical and Electronics Engineering; Salman, Elif; Beşevli, Ceylan; Göksun, Tilbe; Özcan, Oğuzhan; Ürey, Hakan; Master Student; Researcher; Faculty Member; Faculty Member; Faculty Member; Department of Psychology; Department of Media and Visual Arts; Department of Electrical and Electronics Engineering; Graduate School of Sciences and Engineering; Graduate School of Social Sciences and Humanities; College of Social Sciences and Humanities; College of Social Sciences and Humanities; College of Engineering; N/A; N/A; 47278; 12532; 8579A child's early math development can stem from interactions with the physical world. Accordingly, current tangible interaction studies focus on preschool children's formal (symbolic) mathematics, i.e. number knowledge. However, recent developmental studies stress the importance of nonsymbolic number representation in math learning, i.e. understanding quantity relations without counting(more/less). To our knowledge, there are no tangible systems based on this math concept. We developed an initial tangible based mixed-reality(MR) setup with a small tabletop projector and depth camera. Our goal was observing children's interaction with the setup to guide our further design process towards developing nonsymbolic math trainings. In this paper we present our observations from sessions with four 3-to-5 year old children and discuss their meaning for future work. Initial clues show that our MR setup leads to exploratory and mindful interactions, which might be generalizable to other tangible MR systems for child education and could inspire interaction design studies.Publication Metadata only Cutaneous foreign body granulomas associated with lipolytic cocktail: who is the enemy, mesotherapy or drugs injected?(Taylor & Francis Inc, 2017) Kutlubay, Zekayi; İnce, Ümit; Engin, Burhan; N/A; Gökalp, Hilal; Doctor; N/A; Koç University Hospital; N/AMesotherapy is widely used for its lipolytic effect as an alternative procedure to surgical methods. Although many benefits of lipolytic mesotherapy have been observed, numerous side effects have also been reported. Here, we report a case of cutaneous foreign body granulomas that occurred after lipolytic rnesotherapy.Publication Metadata only A novel test coverage metric for concurrently-accessed software components (A work-in-progress paper)(Springer-Verlag Berlin, 2006) N/A; Department of Computer Engineering; N/A; Department of Computer Engineering; Department of Computer Engineering; Taşıran, Serdar; Elmas, Tayfun; Bölükbaşı, Güven; Keremoğlu, M. Erkan; Faculty Member; PhD Student; Undergraduate Student; Reseacher; Department of Computer Engineering; College of Engineering; Graduate School of Sciences and Engineering; College of Engineering, College of Engineering; N/A; N/A; N/A; N/AWe propose a novel, practical coverage metric called "location pairs" (LP) for concurrently-accessed software components. The LP metric captures well common concurrency errors that lead to atomicity or refinement violations. We describe a software tool for measuring LP coverage and outline an inexpensive application of predicate abstraction and model checking for ruling out infeasible coverage targets.Publication Metadata only Unguales plattenepithelkarzinom bei einem patienten mit mal de meleda(Wiley, 2016) Baykal, Can; Sarı, Şule Öztürk; Uyguner, Zehra Oya; Ekinci, Algun Polat; Demir, Özgür; Babuna, Goncagül; Büyükbabani, Nesimi; N/A; Kayserili, Hülya; Faculty Member; School of Medicine; 7945N/A