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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only Targeting cancer cells via tumor-homing peptide CREKA functional PEG nanoparticles(Elsevier, 2016) N/A; N/A; N/A; Department of Chemical and Biological Engineering; Okur, Aysu Ceren; Erkoç, Pelin; Kızılel, Seda; Master Student; PhD Student; Faculty Member; Department of Chemical and Biological Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; N/A; 28376Targeting cell microenvironment via nano-particle based therapies holds great promise for treatment of various diseases. One of the main challenges in targeted delivery of nanoparticles for cancer therapy includes reduced localization of delivery vehicles at tumor site. The therapeutic efficacy of drugs can be improved by recruiting delivery vehicles towards specific region of tumorigenesis in the body. Here, we demonstrate an effective approach in creating PEG particles via water-in-water emulsion technique where tumor-homing peptide CREKA was used for functionalization. Simultaneous conjugation of laminin peptide IKVAV into hydrogel network and influence of altered combinations of ligands on intracellular uptake of anticancer drugs by HeLa cells were investigated. CREKA conjugated hydrogel nanoparticles were more effective to improve apoptotic effects of the model drug Doxorubicin (DOX) compared to that of particles conjugated with other peptides. Fluorescence intensity analysis on confocal micrographs suggested significantly higher cellular uptake of CREKA conjugated PEG particles than internalization of nanoparticles in other groups. We observed that fibrin binding ability of PEG particles could be increased up to 94% through CREKA conjugation. Our results suggest the possibility of cancer cell targeting via CREKA-functional PEG nanoparticles.Publication Metadata only Comparison of convex combination and affine combination of adaptive filters(Ieee, 2009) Singer, Andrew C.; Department of Electrical and Electronics Engineering; Department of Electrical and Electronics Engineering; Kozat, Süleyman Serdar; Erdoğan, Alper Tunga; Faculty Member; Faculty Member; Department of Electrical and Electronics Engineering; College of Engineering; College of Engineering; 177972; 41624In the area of combination of adaptive filters, two main approaches, namely convex and affine combinations have been introduced. In this article, the relation between these two approaches is investigated. First, the problem of obtaining optimal convex combination coefficients is formulated as the projection of the optimal affine combination weights to the unit simplex in a weighted inner product space. Based on this formulation the closed form expressions for optimal combination weights and target MSE levels are obtained for two and three branch cases.Publication Metadata only Effects of alprazolam and haloperidol on thyroglobulin, antithyroglobulin, anti thyroid peroxidase and TSH in Rat(Walter De Gruyter Gmbh, 2018) Samadi, Afshin; Ansari, Mohammad Hassan Khadem; Ulusu, Nuriye Nuray; Faculty Member; School of Medicine; 6807Background: A large number of psychotropic drugs can interfere with the thyroid physiology, function and autoimmunity. Objective: The aim of the present study was to investigate the effects of alprazolam and haloperidol on thyroglobulin, antithyroglobulin (aTg), antithyroid peroxidase, and thyroid stimulating hormone levels on rats. Materials and Methods: First group of adult male Wistar rats was the control, second group received 0.5 mg kg(-1) haloperidol in physiological saline and the third group received 0.5 mg kg(-1) alprazolam, via gastric gavage once daily for 28 days. Plasma levels of all thyroid function tests were measured with chemiluminescent assay. Results: We have investigated a decrease in aTg amounts of control group (5.461 +/- 0.718) compared with drug treated rats with alprazolam (1.433 +/- 0.225) and haloperidol (1.21 +/- 0.228). (P-aTg = 0.00([ALP]), P-aTg = 0.01([HAL])). Although there were not any change in thyroglobulin levels in the haloperidol treated groups (0.9583 +/- 0.014) relative to control group (0.975 +/- 0.015); but in opposition Tg levels decreased significantly in response to alprazolam (0.36 +/- 0.16) compared with the control group (0.975 +/- 0.015), p-values are (P-Tg = 0. 001([ALP])), (P-Tg = 0. 021([HAL])). Conclusion: We found that these two drugs may interfere with the thyroid physiology and metabolism.Publication Metadata only Subspace-based techniques for retrieval of general 3D models(IEEE, 2009) Sankur, Bülent; Dutaǧac, Helin; Department of Computer Engineering; Yemez, Yücel; Faculty Member; Department of Computer Engineering; College of Engineering; 107907In this paper we investigate the potential of subspace techniques, such as, PCA, ICA and NMF in the case of indexing and retrieval of generic 3D models. We address the 3D shape alignment problem via continuous PCA and the exhaustive axis labeling and reflections. We find that the most propitious 3D distance transform leading to discriminative subspace features is the inverse distance transform. Our performance on the Princeton Shape Benchmark is on a par with the state-of-the-art methods. ©2009 IEEE.Publication Metadata only Trans-Atlantic equity volatility connectedness: U.S. and European financial institutions, 2004-2014(Oxford Univ Press, 2016) Diebold, Francis X.; Department of Economics; Yılmaz, Kamil; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 6111We characterize equity return volatility connectedness in the network of major American and European financial institutions, 2004-2014. Our methods enable precise characterization of the timing and evolution of key aspects of the financial crisis. First, we find that during 2007-2008 the direction of connectedness was clearly from the United States to Europe, but that connectedness became bidirectional starting in late 2008. Second, we find an unprecedented surge in directional connectedness from European to U.S. financial institutions in June 2011, consistent with massive deterioration in the health of EU financial institutions. Third, we identify particular institutions that played disproportionately important roles in generating connectedness during the U.S. and the European crises.Publication Metadata only Prophylactic cranial irradiation in small and non-small-cell lung carcinoma(Springer, 2016) Topkan, Erkan; N/A; Selek, Uğur; Faculty Member; School of Medicine; 27211At initial presentation, approximately 10–14 % of small-cell lung carcinoma (SCLC) patients manifest with radiologically evident brain metastases (BM) which arises up to 69 % at 2 years. Similarly, brain failures are reported in 21–54 % of all non-small-cell lung carcinoma (NSCLC) patients, and of these, the brain is the first site of relapse in 15–30 % cases. Although significant improvements have been achieved in local and distant control of both SCLC and NSCLC as a result of implementation of aggressive treatment modalities, unfortunately such aggressive treatments proved no noteworthy viability in lessening of overall brain or brain as the first site of relapse rates. Regarding its counteractive actions on BM emergence, the potential beneficial effects of prophylactic cranial irradiation (PCI) in patients with limited-stage SCLC (LS-SCLC), extensive-stage SCLC (ES-SCLC), and locally advanced NSCLC (LA-NSCLC) have been addressed with several randomized trials and meta-analysis. Based on the results of these investigations, PCI of 25 Gy (2.5 Gy in ten fractions) should be recommended for all medically fit LS- and ES-SCLC patients with any objective response to primary therapy in order to reduce BM incidence rates and to prolong OS times. Although the PCI studies in LA-NSCLC patients suggest significant reductions in BM incidence rates with PCI, yet in the absence of an established survival benefit, it is currently quite difficult to recommend its routine use in LA-NSCLC patients. However, future studies involving high-risk patients may prove worthy in determination of the exact impact if they are needed in order to reliably comment on the issue of PCI in LA-NSCLC patients.Publication Metadata only Performance measures for video object segmentation and tracking(IEEE-Inst Electrical Electronics Engineers Inc, 2004) Erdem, Çiğdem Eroğlu; Sankur, Bülent; Department of Electrical and Electronics Engineering; Tekalp, Ahmet Murat; Faculty Member; Department of Electrical and Electronics Engineering; College of Engineering; 26207We propose measures to evaluate quantitatively the performance of video object segmentation and tracking methods without ground-truth (GT) segmentation maps. The proposed measures are based on spatial differences of color and motion along the boundary of the estimated video object plane and temporal differences between the color histogram of the current object plane and its predecessors. They can be used to localize (spatially and/or temporally) regions where segmentation results are good or bad; and/or they can be combined to yield a single numerical measure to indicate the goodness of the boundary segmentation and tracking results over a sequence. The validity of the proposed performance measures without GT have been demonstrated by canonical correlation analysis with another set of measures with GT on a set of sequences (where GT information is available). Experimental results are presented to evaluate the segmentation maps obtained from various sequences using different segmentation approaches.Publication Metadata only Evolution of transformation plasticity in austenite-to-bainite phase transformation: a multi parameter problem(Elsevier Science Sa, 2012) Lambers, Hans -Gerd; Maier, Hans Jürgen; Department of Mechanical Engineering; Canadinç, Demircan; Faculty Member; Department of Mechanical Engineering; College of Engineering; 23433The current paper presents a thorough experimental analysis of the austenite-to-bainite phase transformation, and provides insight into microstructural changes associated with the observed transformation plasticity (TP). Specifically, the evolution of TP was studied in the presence of several parameters, namely pre-deformation, temperature and superimposed constant stresses, and the observed phenomena were linked to microstructural changes under these circumstances based on experimental data. One major finding is that the evolution of TP strains is governed both by the superimposed external stresses and the temperature dependence of internal stresses introduced by pre-deformation.Publication Metadata only Chiropractic alters TMS induced motor neuronal excitability: preliminary findings(Springer International Publishing Ag, 2014) Haavik, Heidi; Niazi, Imran Khan; Duehr, Jens; Kinget, Mat; Ugincius, Paulius; Department of Physics; N/A; Sebik, Oğuz; Yılmaz, Gizem; Türker, Kemal Sıtkı; Researcher; PhD Student; Faculty Member; Department of Physics; College of Sciences; Graduate School of Health Sciences; School of Medicine; Koç University Hospital; N/A; N/A; 6741The objective of this study was to use the electromyography (EMG) via surface and intramuscular single motor unit recordings to further characterize the immediate sensorimotor effects of spinal manipulation and a control intervention using TMS. The results provide evidence that spinal manipulation of dysfunctional spinal segments increases low threshold motoneurone excitability.Publication Metadata only Sequence of theory-of-mind acquisition in Turkish children from diverse social backgrounds(Wiley, 2018) Brink, Kimberly A.; Wellman, Henry M.; Department of Psychology; N/A; Selçuk, Bilge; Ekerim-Akbulut, Müge; Faculty Member; PhD Student; Department of Psychology; College of Social Sciences and Humanities; Graduate School of Social Sciences and Humanities; 52913; 311454We examined the sequence of theory of mind (ToM) acquisition in 260 Turkish children (M-age=53.36months, SD=10.37) and the demographic factors associated with it. Children came from 5 different cities in Turkey. Their ToM skills were measured using ToM Scale, which probes various mental state understandings from diverse desires to hidden emotions. These Turkish children demonstrated the traditional, collectivist ToM acquisition pattern evident in Iran and China with earlier understanding of knowledge access than diverse beliefs, not the western, individualist pattern evident in the United States, Australian, and German children. Gender, socio-economic status (SES), and number of adults living in the home influenced the pace of children's ToM acquisitions. A post hoc analysis examined a minority of children that exhibited individualist ToM acquisition with earlier achievement of diverse beliefs than knowledge access. The results contribute to a fuller sociocultural understanding of ToM development including examination of variations within a single heterogeneous developing country. They also further suggest the importance of exposure to different ideas and beliefs in large households for earlier understanding of varying belief states. Highlights We assessed theory of mind (ToM) acquisition in 260 Turkish children whose families spanned a large range of social class circumstances. We measured ToM via Wellman and Liu's scale (2004), consisting of five items testing diverse desires, diverse belief, knowledge access, false belief, and hidden emotion. The Turkish children demonstrated the traditional, collectivist ToM acquisition pattern, but a minority of children exhibited individualistic ToM acquisition. In cultures where elements of individualism and collectivism are blended, children can come to different orders of acquisition in accord with recent arguments that cultural development often represents a coexistence of different reasoning styles.