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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only test(KU yayınevi, 2024-12-30) bir, bir; test, test; Çanak, Tuba Akbaytürk; Department of Molecular Biology and Genetics; College of EngineeringjjlkjlşkkşlkşlşlkşkşlkPublication Metadata only Are the New Kawasaki-like Syndromes in the children associated with Covid-19?(Dokuz Eylül University Institute of Health Sciences, 2024) N/A; Ulusu, Nuriye Nuray; Aydemir, Duygu; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health SciencesCOVID-19 has become a significant public health problem since December 2019, and despite vaccination, people are still infected and have died because of COVID-19. COVID-19 mainly affects older adults and cardiovascular diseases, and immune disorders. On the other hand, some young adults infected by COVID-19 show severe symptoms similar to Kawasaki Disease (KD) called Kawasaki-like syndrome syndromes and cardiovascular complications, including aneurysms, left ventricular dysfunction, pericarditis, myocarditis, valvular regurgitation, or coronary arterial ectasia, tested positive for the COVID19 virus, up to two-thirds of cases. On the other hand, people with glucose-6-phosphate dehydrogenase (G6PD) deficiency are more vulnerable to COVID-19 infection, and KD with G6PD deficiency has been reported previously. Therefore, children with G6PD deficiency or KD disease can be more vulnerable to COVID-19; thus, we discuss the possible role of COVID-19 in KD-like syndrome and G6PD deficiency associated with severe symptoms in children. Also, the possible correlation between COVID-19 infection and Kawasaki disease-like syndromes should be further investigated.Publication Metadata only An alarming emergence of measles in Europe: gaps and future directions(Galenos Publ House, 2024) Ozsurekci, Yasemin; Ergönül, Önder; Koç Üniversitesi İş Bankası Enfeksiyon Hastalıkları Uygulama ve Araştırma Merkezi (EHAM) / Koç University İşbank Center for Infectious Diseases (KU-IS CID); School of MedicineN/APublication Metadata only Investigating the involvement of fibroblast growth factors in adipose tissue thermogenesis(Istanbul University Press, 2024) Department of Molecular Biology and Genetics; Kır, Serkan; Department of Molecular Biology and Genetics; College of ScienceObjective: Thermogenesis in white and brown adipose tissues can be induced by various stimuli, including cold exposure, β-adrenergic stimulation, and tumor growth. Fibroblast growth factor (FGF) 21 has emerged as an important mediator of thermogenesis. This study investigated the involvement of other FGF family members in the regulation of adipose tissue thermogenesis. Materials and Methods: Mice were exposed to cold and administrated a β-adrenergic agonist (CL-316,243) to stimulate a thermogenic response in adipose tissues. Stromavascular fractions isolated from white and brown adipose tissues were cultured and differentiated into primary adipocytes. These cells were treated with recombinant FGFs. Changes in the expression levels of thermogenic genes and FGFs were determined by real-time quantitative PCR. Results: Cold exposure stimulated thermogenic gene expression in the adipose tissue, which was accompanied by the upregulation of certain FGFs. Ffg9 and Fgf21 were prominently induced in white and brown adipose tissues. β-adrenergic stimulation also upregulated thermogenic genes in adipocytes. Fgf21 was identified as the main responder to the β-adrenergic pathway. The administration of recombinant FGFs to cultured primary white and brown adipocytes induced thermogenic genes, including uncoupling protein-1 (Ucp1). FGF2, FGF9, and FGF21 triggered the most significant Ucp1-inducing effects in these cells. Conclusion: FGF21 is as a prominent inducer of thermogenesis in adipose tissue and a promising therapeutic target against cardiovascular and metabolic diseases. FGF2 and FGF9 potently promote thermogenic gene expression in adipocytes. Therefore, their therapeutic targeting should be considered to enhance energy metabolism in adipose tissues.Publication Metadata only TASL practice guidance on the clinical assessment and management of patients with nonalcoholic fatty liver disease(Kare Publ, 2023) Yilmaz, Yusuf; Adali, Gupse; Cosar, Arif Mansur; Sertesen, Elif; Gokcan, Hale; Bahcecioglu, Halil Ibrahim; Sahin, Mustafa; Tulunay, Cansin; Ergun, Ihsan; Turan, Ilker; Idilman, Ilkay Sedakat; Celikel, Cigdem; Kirimlioglu, Hale; Akyol, Gulen; Yilmaz, Funda; Sokmensuer, Cenk; Guveli, Hakan; Akarca, Ulus Salih; Akyuz, Umit; Genc, Volkan; Akyildiz, Murat; Yazihan, Nuray; Tutar, Engin; Ates, Fehmi; Dincer, Dinc; Balaban, Yasemin; Kiyici, Murat; Akdogan, Meral; Sonsuz, Abdullah; Idilman, Ramazan; Zeybel, Müjdat; School of MedicineNonalcoholic fatty liver disease (NAFLD) is a multisystem disease and is significantly associated with obesity, insulin resistance, type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease. NAFLD has become the most prevalent chronic liver disease in Western countries, and the proportion of NAFLD-related cirrhosis among patients on liver transplantation waiting lists has increased. In light of the accumulated data about NAFLD, and to provide a common approach with multi-disciplines dealing with the subject, it has become necessary to create new guidance for diagnosing and treating NAFLD. This guidance was prepared following an interdisciplinary study under the leadership of the Turkish Association for the Study of the Liver (TASL), Fatty Liver Special Interest Group. This new TASL Guidance is a practical application guide on NAFLD and was prepared to standardize the clinical approach to diagnosing and treating NAFLD patients. This guidance reflects many advances in the field of NAFLD. The proposals in this guidance are meant to aid decision-making in clinical practice. The guidance is primarily intended for gastroenterology, endocrinology, metabolism diseases, cardiology, internal medicine, pediatric specialists, and family medicine specialists.Publication Metadata only Immunotherapy for lung cancer(Turkiye Klinikleri, 2023) Karadurmuş,N.; Akyürek,N.; Aydiner,A.; Savaş,R.; Sönmez,Ö.; Şendur,M.A.N.; Oyan,B.; Yalman,D.; Yilmaz,M.U.; Yilmaz,Ü.; Göker,E.; Yumuk, Perran Fulden; School of MedicineLung cancer is one of the leading causes of cancer-related deaths in men and women. Similar to the approach with other cancer types, lung cancer staging is crucial in planning an effective treatment plan and predicting patient prognosis. Effective immunotherapies for patients with non-small cell lung cancer and non-genomic driver mutations are rapidly evolving. Moreover, anti-programmed death re-ceptor-1 (PD-1)/programmed death ligand 1 (PD-L1)-based treatments have become the first-line standard of care. Despite shortcomings, PD-L1 expression level seems currently to be a relatively reliable predictor of the clinical efficacy of treatment with anti-PD-1/PD-L1 anti-bodies. However, additional biomarkers are required to better personalize treatment options for these patients. This review aimed to increase awareness of lung cancer and immunotherapy treatment options, depending on patient and disease stage characteristics.Publication Metadata only Determination of the plasma levels of growth arrest specific 6 in colon cancer patients(Marmara Univ, Inst Health Sciences, 2023) Tezcan, Songul; Izzettin, Fikret Vehbi; Ozakpinar, Ozlem Bingol; Atalay, Vafi; Uras, Fikriye; Yumuk, Perran Fulden; School of MedicineObjective: Growth arrest-specific 6 (GAS 6) has a role in cell proliferation and was detected in different cancer types. The aim of this study was to evaluate the plasma GAS 6 levels in colon cancer patients. Methods: This was a prospective study and conducted in a research and training hospital in Turkey. Thirty-three healthy volunteers were enrolled in the control group, thirty-three colon cancer patients who were diagnosed with colon cancer for the first time. Sociodemographic characteristics of participants were recorded. Blood samples of the control group were taken once a time. Patients' blood samples were taken before and one month after surgery. Results: There were no statistically significant differences between the sociodemographic characteristics of the two groups. The mean plasma GAS 6 levels in control were significantly higher than that of colon cancer patients (p<.0001). There is a statistically significant increase in GAS 6 values after surgery (p<.0001). Conclusion: It was observed that plasma GAS 6 levels of the patients were lower than the control group and were elevated after surgery. We think that our study will contribute to the literature in addition to studies showing that GAS 6 levels may be associated with survival and prognosis in different cancer types.Publication Metadata only Gait analysis in idiopathic normal pressure hydrocephalus: a single centre experience(Galenos, 2023) Youssef, Hussein; Özkan, Esra; Çakmak, Özgür Öztop; Akar, Kardelen; Kahraman, Atilla Deniz; Samancı, Mustafa Yavuz; Vural, Atay; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of MedicineIntroduction: Gait impairment is the earliest symptom of idiopathic normal pressure hydrocephalus (iNPH). This study objectively investigates gait changes using Ambulatory Parkinson’s Disease Monitoring inertial sensors after cerebrospinal fluid withdrawal in patients with iNPH. Methods: Two-minute walkway tests were performed in eleven patients with iNPH before and after the spinal tap test (TT) or ventriculoperitoneal shunt surgery. Gait parameters were analyzed and compared for each patient individually before and after the intervention. Results: Eleven patients with iNPH (six female, five male) with a median age of 76 (68-76) were included in the study. After the spinal TT or ventriculoperitoneal shunt surgery, patients exhibited increased cadence (steps per minute) and decreased step and stride time (p=0.008, for all). Conclusion: APDM inertial sensors may provide a quantitative gait assessment in patients with iNPH.Publication Metadata only Indomethacin affects the inflammatory response via interaction with the rhoa-actin cytoskeleton in THP-1 cells(Istanbul University Press, 2023) Aldogan, Ebru Haciosmanoglu; Bulut, Seyma; Yapislar, Hande; Guncer, Basak; Bektas, Muhammet; Yöntem, Fulya Dal; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of MedicineObjective: Inflammation is a complex reaction present in numerous disorders. Indomethacin, a compound possessing an indoline core, is a Nonsteroidal Anti-Inflammatory Drug (NSAID) that is commonly prescribed for inflammation and pain. The actin network, plays a major role in cellular activities and it’s regulated by by Rho GTPases has important implications for cellular dynamics and orientation. In this research, we explore the effects of indomethacin on the inflammatory response as mediated via RhoA and pyrin inflammatory complexes using an inflammatory disease model with relation actin cytoskeleton. Materials and Methods: This study used Western blotting to examine the impact of indomethacin on the assembly processes related to the pyrin inflammasome complex and the RhoA signaling pathway in Lipopolysaccharide-stimulated THP-1 cells. Actin-indomethacin interaction was analyzed by Differential Scanning Fluorimetry (DSF). Results: We found that while the expression levels of pyrin decreased, phosphorylated-RhoA increased but overall RhoA levels did not change. The equilibrium dissociation constant (KD) for the G-actin-indomethacin complex was calculated to be 9.591± 1.608 ng/mL (R2= 0.8582) using ∆Tm measurements of indomethacin by DSF. Conclusion: Moreover, the effects of indomethacin on inflammation pathways may provide insight into the molecular mechanisms of pyrin inflammasome formation in various autoimmune diseases.Publication Metadata only Influence of soft segment structure, hydrogen bonding, and diisocyanate symmetry on morphology and properties of segmented thermoplastic polyurethanes and polyureas(Tubitak Scientific & Technological Research Council Turkey, 2023) Department of Chemistry; Yılgör, Emel; Yılgör, İskender; Department of Chemistry; College of SciencesA comprehensive review of the structure-morphology-property relations in segmented thermoplastic polyurethanes and polyureas (TPU) is provided. Special emphasis is given to the influence of the soft segment structure, polarity, and molecular weight, diisocyanate symmetry and the nature, extent, and strength of hydrogen bonding on the morphology and thermal and mechanical properties of TPUs. Experimental results obtained on composition-dependent TPU morphology and properties by various techniques were also compared by the morphology profiles generated by computational methods such as quantum mechanical calculations and molecular dynamics simulations.