Are the New Kawasaki-like Syndromes in the children associated with Covid-19?

Abstract

COVID-19 has become a significant public health problem since December 2019, and despite vaccination, people are still infected and have died because of COVID-19. COVID-19 mainly affects older adults and cardiovascular diseases, and immune disorders. On the other hand, some young adults infected by COVID-19 show severe symptoms similar to Kawasaki Disease (KD) called Kawasaki-like syndrome syndromes and cardiovascular complications, including aneurysms, left ventricular dysfunction, pericarditis, myocarditis, valvular regurgitation, or coronary arterial ectasia, tested positive for the COVID19 virus, up to two-thirds of cases. On the other hand, people with glucose-6-phosphate dehydrogenase (G6PD) deficiency are more vulnerable to COVID-19 infection, and KD with G6PD deficiency has been reported previously. Therefore, children with G6PD deficiency or KD disease can be more vulnerable to COVID-19; thus, we discuss the possible role of COVID-19 in KD-like syndrome and G6PD deficiency associated with severe symptoms in children. Also, the possible correlation between COVID-19 infection and Kawasaki disease-like syndromes should be further investigated.