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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3

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Department: search.filters.department.Department of MathematicsSubject: search.filters.subject.Clinical neurology

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    Cerebral microhemorrhages detected by susceptibility-weighted imaging in amateur boxers
    (Amer Soc Neuroradiology, 2011) Hasiloğlu, Z. I.; Albayram, S.; Selçuk, H.; Delil, S.; Arkan, B.; Başköy, L.; Department of Mathematics; Ceyhan, Elvan; Faculty Member; Department of Mathematics; College of Sciences; N/A
    Background and Purpose: SWI is a new technique for evaluating diffuse axonal injury associated with punctate hemorrhages. The aim of our study was to determine the prevalence of cerebral microhemorrhages in amateur boxers compared with nonboxers by using SWI and to evaluate the sensitivity of SWI compared with T2 FSE and T2*GE sequences. MATERIALS and METHODS: We performed cranial MR imaging with a 1.5T scanner in 21 amateur boxers and 21 control subjects. The study protocol included conventional MR images, T2 FSE, T2*GE, and SWI sequences. The proportions of boxers and controls having CSP, DPVS, cerebral atrophy, cerebellar atrophy, ventricular dilation. PSWMD, and microhemorrhages were computed and were compared by using the chi(2) test of proportions. The relationship between microhemorrhages and boxing-related covariates was assessed by using the Wilcoxon rank sum test. The association between the categories was tested by using the Fisher exact test. RESULTS: Using SWI, microhemorrhages were found in 2 (9.52%) of 21 boxers. The microhemorrhages were not visible on T2 FSE or T2*GE images. The proportion of subjects with microhemorrhages did not differ significantly between the boxers and control subjects (chi(2) = 0.525, df = 1, P = .4688). The prevalence of CSP and DPVS was significantly higher in the boxers than in the control subjects. CONCLUSIONS: More microhemorrhages were detected in amateur boxers than in controls, but this difference was not statistically significant.
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    The role of base excision repair in major depressive disorder and bipolar disorder
    (Elsevier, 2022) Küçüker, Mehmet Utku; Özerdem, Ayşegül; Cabello Arreola, Alejandra; Ho, Ada M. C.; Joseph, Boney; Webb, Lauren M.; Croarkin, Paul E.; Frye, Mark A.; Veldic, Marin; Department of Mathematics; Ceylan, Deniz; Faculty Member; Department of Mathematics; College of Sciences; 137755
    Background: In vivo and in vitro studies suggest that inflammation and oxidative damage may contribute to the pathogenesis of major depressive disorder (MDD) and bipolar disorder (BD). Imbalance between DNA damage and repair is an emerging research area examining pathophysiological mechanisms of these major mood disorders. This systematic review sought to review DNA repair enzymes, with emphasis on the base excision repair (BER), in mood disorders.Methods: We conducted a comprehensive literature search of Ovid MEDLINE (R) Epub Ahead of Print, Ovid MEDLINE (R) In-Process & Other Non-Indexed Citations, Ovid MEDLINE (R) Daily, EMBASE (1947), and PsycINFO for studies investigating the alterations in base excision repair in patients with MDD or BD.Results: A total of 1364 records were identified. 1352 records remained after duplicates were removed. 24 records were selected for full-text screening and a remaining 12 articles were included in the qualitative synthesis. SNPs (single nucleotide polymorphisms) of several BER genes have been shown to be associated with MDD and BD. However, it was difficult to draw conclusions from BER gene expression studies due to conflicting findings and the small number of studies. Limitations: All studies were correlational so it was not possible to draw conclusions regarding causality.Conclusion: Future studies comparing DNA repair during the manic or depressive episode to remission will give us a better insight regarding the role of DNA repair in mood disorders. These alterations might be utilized as diagnostic and prognostic biomarkers as well as measuring treatment response.