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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3

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Department: search.filters.department.Department of MathematicsSubject: search.filters.subject.Psychiatry

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    Reduced anterior cingulate gray matter volume and thickness in subjects with deficit schizophrenia
    (Elsevier, 2013) Takayanagi, Mizuho; Wentz, Jacqueline; Takayanagi, Yoichiro; Schretlen, David J.; Wang, Lei; Suzuki, Michio; Sawa, Akira; Barta, Patrick E.; Ratnanather, J. Tilak; Cascella, Nicola G.; Department of Mathematics; Ceyhan, Elvan; Faculty Member; Department of Mathematics; College of Sciences; N/A
    Background: Patients with deficit schizophrenia (D-SZ) differ from patients with the non-deficit form of schizophrenia (ND-SZ) in several aspects such as risk factors, neurobiological correlates, treatment response and clinical outcome. It has been debated if brain morphology could differentiate D-SZ from ND-SZ. Anterior cingulate gyrus (ACG) region regulates cognitive and emotional processing and past studies reported structural changes in this region in patients with SZ. Methods: 1.5-T 3D MRI scans were obtained from 18 D-SZ patients, 30 ND-SZ patients and 82 healthy controls (HCs). We used FreeSurfer-initalized labeled cortical distance mapping (FSLCDM) to measure ACG gray matter volume, cortical thickness, and area of the gray/white interface. Furthermore, cortical thickness was compared among the 3 groups using the pooled labeled cortical distance mapping (LCDM) method. Results: The ACG cortex of the D-SZ group was thinner than the ND-SZ group. Pooled LCDM demonstrated that the ACG cortex was bilaterally thinner in both the ND-SZ group and the D-SZ group compared with the control group. The right ACG gray matter volume was significantly reduced in D-SZ patients as compared with healthy controls (p = 0.005 Conclusion: Our data suggest that qualitative, categorical differences in neuroanatomy may distinguish between deficit and non-deficit subtypes of schizophrenia. (C) 2013 Elsevier B. V. All rights reserved.
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    The role of base excision repair in major depressive disorder and bipolar disorder
    (Elsevier, 2022) Küçüker, Mehmet Utku; Özerdem, Ayşegül; Cabello Arreola, Alejandra; Ho, Ada M. C.; Joseph, Boney; Webb, Lauren M.; Croarkin, Paul E.; Frye, Mark A.; Veldic, Marin; Department of Mathematics; Ceylan, Deniz; Faculty Member; Department of Mathematics; College of Sciences; 137755
    Background: In vivo and in vitro studies suggest that inflammation and oxidative damage may contribute to the pathogenesis of major depressive disorder (MDD) and bipolar disorder (BD). Imbalance between DNA damage and repair is an emerging research area examining pathophysiological mechanisms of these major mood disorders. This systematic review sought to review DNA repair enzymes, with emphasis on the base excision repair (BER), in mood disorders.Methods: We conducted a comprehensive literature search of Ovid MEDLINE (R) Epub Ahead of Print, Ovid MEDLINE (R) In-Process & Other Non-Indexed Citations, Ovid MEDLINE (R) Daily, EMBASE (1947), and PsycINFO for studies investigating the alterations in base excision repair in patients with MDD or BD.Results: A total of 1364 records were identified. 1352 records remained after duplicates were removed. 24 records were selected for full-text screening and a remaining 12 articles were included in the qualitative synthesis. SNPs (single nucleotide polymorphisms) of several BER genes have been shown to be associated with MDD and BD. However, it was difficult to draw conclusions from BER gene expression studies due to conflicting findings and the small number of studies. Limitations: All studies were correlational so it was not possible to draw conclusions regarding causality.Conclusion: Future studies comparing DNA repair during the manic or depressive episode to remission will give us a better insight regarding the role of DNA repair in mood disorders. These alterations might be utilized as diagnostic and prognostic biomarkers as well as measuring treatment response.