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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only Are the New Kawasaki-like Syndromes in the children associated with Covid-19?(Dokuz Eylül University Institute of Health Sciences, 2024) N/A; Ulusu, Nuriye Nuray; Aydemir, Duygu; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health SciencesCOVID-19 has become a significant public health problem since December 2019, and despite vaccination, people are still infected and have died because of COVID-19. COVID-19 mainly affects older adults and cardiovascular diseases, and immune disorders. On the other hand, some young adults infected by COVID-19 show severe symptoms similar to Kawasaki Disease (KD) called Kawasaki-like syndrome syndromes and cardiovascular complications, including aneurysms, left ventricular dysfunction, pericarditis, myocarditis, valvular regurgitation, or coronary arterial ectasia, tested positive for the COVID19 virus, up to two-thirds of cases. On the other hand, people with glucose-6-phosphate dehydrogenase (G6PD) deficiency are more vulnerable to COVID-19 infection, and KD with G6PD deficiency has been reported previously. Therefore, children with G6PD deficiency or KD disease can be more vulnerable to COVID-19; thus, we discuss the possible role of COVID-19 in KD-like syndrome and G6PD deficiency associated with severe symptoms in children. Also, the possible correlation between COVID-19 infection and Kawasaki disease-like syndromes should be further investigated.Publication Metadata only Does Covid-19 infection alter serum biochemical and hematological biomarkers in deceased dementia patients?(Walter de Gruyter GmbH, 2024) Yucel, Muammer; Koseoglu, Mehmet; Ulusu, Nuriye Nuray; Aydemir, Duygu; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health SciencesObjectives The elderly population is categorized as a risk group for COVID-19 infection, and dementia is the primary cause of disability in elderly individuals and affects 70 % of the elderly population. In this study, we evaluated the blood and serum biomarkers of deceased dementia patients infected by COVID-19 compared to the survived dementia and non-dementia patients.Methods Laboratory biomarkers of 11 dementia patients infected by COVID-19 have been used for this study. The five patients' serum biochemistry and blood data were compared with the six patients who died because of COVID-19. Additionally, data from nine patients aged 85-96 infected with COVID-19 without dementia have been used to compare the difference between dementia and non-dementia individuals.Results D-dimer, C-reactive protein (CRP), glucose, blood urea nitrogen (BUN), alanine transaminase (ALT), aspartate aminotransferase (AST), troponin, procalcitonin, red cell distribution width (RDW), white blood cell (WBC), neutrophil (NEU) and %NEU levels significantly increased in the deceased dementia patients compared to the survived and non-dementia individuals. Calcium (Ca), hematocrit (HCT), red blood cells (RBC), lymphocyte (%LYM), monocyte %MONO, and basophil (%BASO) levels significantly decreased in the deceased dementia patients compared to the survived and non-dementia individuals infected by COVID-19.Conclusions Serum biochemistry and hematological biomarkers, including D-dimer, CRP, glucose, ALT, AST, BUN, troponin, procalcitonin, RDW, RBC, WBC, NEU, %NEU, Ca, HCT, %LYM, %MONO, and %BASO were significantly altered in deceased dementia patients infected by COVID-19 compared to the survived individuals.Publication Metadata only Therapeutic targets of probiotics in Parkinson disease: a systematic review of randomized controlled trials(Iran University of Medical Sciences, 2024) Atak, Elif Sina; Yildiz, Dilara; Kocaturk, Ruemeysa Rabia; Ozcan, Oznur Ozge; Erguzel, Turker Tekin; Karahan, Mesut; Tarhan, Nevzat; Temizyürek, Arzu; School of MedicineIntroduction: Parkinson disease is the world's second most prevalent neurological disease. In this disease, intracytoplasmic neuronal inclusions are observed in enteric neurons in the gastrointestinal tract, and the composition of the intestinal microbiome is altered. These changes correlate with the motor phenotype. A systematic review was conducted to determine the effect of using probiotics in Parkinson disease. Methods: Scopus, PubMed, Web of Science, the Cochrane Library, ScienceDirect, and Ov & imath;dLWW were searched until April 2021. A total of 27395 records were found according to inclusion and exclusion criteria with the following outcomes: Parkinson disease rating, oxidative stress, and gastrointestinal system markers. Data search, article selection, and data extraction assessments were performed according to the PRISMA (preferred reporting items for systematic reviews and meta -analyses) guidelines. The Jadad scale was used to rate the evidence's quality. Results: Our study information was gathered from 5 randomized controlled trials involving 350 individuals with Parkinson disease receiving probiotic supplements. Parkinson disease rating and non -motor symptoms test were performed in the samples. Also, oxidative stress (glutathione, malondialdehyde) and gastrointestinal system symptoms (bowel opening frequency, gut transit time, complete bowel movement, spontaneous bowel movements) were evaluated during 4-12 weeks of using probiotics in these patients. Conclusion: While all high -quality studies demonstrate improvement in disease symptoms of the patients, currently sufficient data are not available to recommend the use of probiotics for people with Parkinson disease in clinical practice.Publication Metadata only ICS educational module: the practice of uroflowmetry in adults(Elsevier B.V., 2024) Agarwal, Mayank Mohan; Rubilotta, Emanuele; De Nunzio, Cosimo; Rosier, Peter; Tarcan, Tufan; Acar, Ömer; School of MedicineAim: To present the body of evidence behind the International Continence Society (ICS) educational module on “Practice of uroflowmetry in adults” which consists of a PowerPoint® presentation. Methods: This evidence review has been prepared by a working group instituted by the ICS Urodynamics Committee. The method used included systematic literature review, consensus formation by the members of the Working Group, and review by members of the ICS Urodynamics Committee core panel. Results: A total of 104 articles were included in this systematic review. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Evidence analysis was conducted along the following themes: physiology of voiding, pathophysiology of lower urinary tract dysfunction, technique of uroflowmetry, quality check of the uroflowmetry test, interpretation and reporting of uroflowmetry findings. Conclusions: Uroflowmetry is the most commonly utilized diagnostic test in the evaluation of adults presenting with lower urinary tract symptoms. The practice of uroflowmetry exhibits variations which might lead to inconclusive or inaccurate assessments. The ICS educational module on the Practice of Uroflowmetry in Adults provides up-to-date and evidence-based guidance in an effort to establish standards in the technique, interpretation, and reporting of uroflowmetry.Publication Metadata only Best practice for videourodynamics: a teaching module of the international continence society urodynamics committee(Elsevier B.V., 2024) Patel, Mittal; Bhide, Alka A.; Digesu, G.A.; Tarcan, Tufan; School of MedicineAims: To present the ICS Teaching Module on Videourodynamics (VUD) and the information as a best practice report. Methods: This teaching module was developed by the (International Continence Society) ICS Urodynamics Committee to assist ICS members in their clinical practice. A detailed literature search on studies and guidelines published on the clinical role of VUD as well as expert opinions have been considered. A slideshow on VUD has been developed and will be presented to the members of the ICS Urodynamics Committee and will be made available to the ICS membership on the ICS website. Results: The scientific evidence on the indications, recommended techniques and interpretation of VUD in patients presenting with lower urinary tract symptoms has been summarised. Troubleshooting and optimisation of the imaging as also been described to minimise the radiation exposure to both patient and healthcare professionals. Conclusions: The scientific evidence on the clinical role, techniques and the indications for VUD is sparse with varying clinical expert opinion. The ICS Urodynamics Committee recommends its use as a second line diagnostic tool for a thorough visualisation of the lower urinary tract anatomy and real time function. This manuscript summarises the evidence and provides practice recommendations on VUD for teaching purposes in the framework of an ICS teaching module.Publication Metadata only Effect of kinesio tape applied to supraspinatus muscle on shoulder scaption strength and upper extremity stability in healthy women aged 20 to 30 years: a double blind randomized controlled trial(EDRA SPA, 2024) Sokucu, Sami; Taşkıran, Özden Özyemişçi; Topaloğlu, Mahir; Albayrak, Havvanur; School of Medicine; Koç University HospitalObjective. To investigate the effect of kinesio tape applied to the supraspinatus muscle on shoulder scaption muscle strength and upper extremity stability in healthy women. Methods. 26 healthy female volunteers aged 20-30 years were included in the study. Individuals were randomized into two groups, kinesio taping (n = 13) and sham taping (n = 13). In the kinesio taping group a Y-shaped tape was applied to the supraspinatus muscle in the direction of facilitation while in the sham group an I tape was applied on the scapula. Before taping and 20 minutes after taping the shoulder scaption strength was measured with a dynamometer and functional evaluations were performed by the closed kinetic chain upper extremity stability test. Results. In the kinesio tape group, median scaption strength decreased after taping (p = 0.016). The median contact, normalized, and power scores increased significantly (respectively, p = 0.001, p = 0.001, and p = 0.001). In the sham group there was no significant difference in the median scaption strength after taping; the median contact, normalized and power scores increased significantly (p = 0.004, p = 0.004, and p = 0.006, respectively). There was no significant difference in scaption strength and upper extremity stability test scores between groups. After taping the changes were categorized as "no change", "increase" and "decrease" according to the minimal clinically significant difference value, the number of individuals with increased scaption strength was higher in the kinesio tape group compared to the sham group, although not statistically significant. Conclusions. The significance of kinesio taping applied to healthy women was not observed compared to sham taping on shoulder scaption muscle strength and upper extremity stability.Publication Metadata only Prognostic value of body composition in therapy-naive patients with non-small cell lung cancer(Akademi Doktorlar Yayınevi, 2024) Kiratli Yolcu, Tugba; Kesim, Selin; Filizoglu, Nuh; Ones, Tunc; Basoglu, Tugba; Ozturk, Mehmet Akif; Yumuk, Perran Fulden; School of MedicineThe objective of this study was to assess the impact of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), skeletal muscle mass volume (SMMV), and VAT/SAT ratio on the prognosis of therapy naive metastatic non-small cell lung cancer (NSCLC) patients undergoing different therapy regimens. Eighty three patients with stage-IV NSCLC who were received at least one cycle of platinum-based chemotherapy (PBCT) or tyrosine kinase inhibitor (TKI) therapy included in this retrospective study. Pre-treatment multi-slice and single-slice computed tomography images of PET/CT scans were used for the assessment of body composition. The effect of anthropometric measurements on clinical outcomes for advanced NSCLC patients was investigated with survival analysis for each treatment subgroup. In univariate analyses, female gender (p= 0.03), presence of bone metastasis (p= 0.02), presence of adrenal metastasis (p< 0.005), SAT volume (p= 0.01), VAT/SAT ratio (p= 0.02) and serum albumin levels (p= 0.01) were found to be statistically significant for overall survival (OS) in TKI treatment group. In multivariate analyses, only serum albumin level (p< 0.005) remained an independent risk factor. No significant results were found in the PBCT treatment group. Single-slice volume calculation method for VAT measurement was highly correlated with a multi-slice method which reflects the entire abdominopelvic region. In conclusion, our study indicates that adipose tissue and muscle mass volume alone do not significantly affect survival in patients with metastatic NSCLC. However, hypoalbuminemia was identified as an independent negative prognostic factor.Publication Metadata only HIV and intersectional stigma among people living with HIV and healthcare workers and antiretroviral therapy adherence in the Dominican Republic(SAGE, 2024) Kerr, Jelani; Yigit, Ibrahim; Long, Dustin M.; Paulino-Ramirez, Robert; Waters, John; Hao, Jiaying; Nyblade, Laura; Varas-Diaz, Nelson; Naar, Sylvie; Bond, Christyenne L.; Budhwani, Henna; Turan, Janet Molzan; School of MedicineBackground HIV-related stigma, discrimination, and social marginalization undermines optimal HIV care outcomes. More research examining the impact of HIV-related stigma, discrimination, other interlocking forms of oppression, and antiretroviral therapy (ART) adherence is needed to optimize HIV treatment programming. This study uses data from two clinics in the Dominican Republic to examine client and healthcare worker (HCW) perceptions of HIV and intersectional stigmas among people living with HIV.Methods Surveys exploring demographics, HIV-related stigma, various dimensions of discrimination (race/ethnicity, HIV status, sexual orientation), healthcare engagement, and medication adherence were collected from 148 clients and 131 HCWs. Analysis of variance was conducted to examine differences in stigma by clinic and logistic regressions were used to determine predictors of optimal client medication adherence.Results Perceived discrimination in healthcare facilities due to clients' sexual orientation retained significance in crude and multivariable logistic regression models and was negatively associated with ART adherence (aOR:0.79; 95% CI:0.66, 0.95).Discussion Findings highlight the importance of implementing strategies to address stigma, discrimination, and social marginalization, particularly within healthcare facilities.Publication Metadata only TASL practice guidance on the clinical assessment and management of patients with nonalcoholic fatty liver disease(Kare Publ, 2023) Yilmaz, Yusuf; Adali, Gupse; Cosar, Arif Mansur; Sertesen, Elif; Gokcan, Hale; Bahcecioglu, Halil Ibrahim; Sahin, Mustafa; Tulunay, Cansin; Ergun, Ihsan; Turan, Ilker; Idilman, Ilkay Sedakat; Celikel, Cigdem; Kirimlioglu, Hale; Akyol, Gulen; Yilmaz, Funda; Sokmensuer, Cenk; Guveli, Hakan; Akarca, Ulus Salih; Akyuz, Umit; Genc, Volkan; Akyildiz, Murat; Yazihan, Nuray; Tutar, Engin; Ates, Fehmi; Dincer, Dinc; Balaban, Yasemin; Kiyici, Murat; Akdogan, Meral; Sonsuz, Abdullah; Idilman, Ramazan; Zeybel, Müjdat; School of MedicineNonalcoholic fatty liver disease (NAFLD) is a multisystem disease and is significantly associated with obesity, insulin resistance, type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease. NAFLD has become the most prevalent chronic liver disease in Western countries, and the proportion of NAFLD-related cirrhosis among patients on liver transplantation waiting lists has increased. In light of the accumulated data about NAFLD, and to provide a common approach with multi-disciplines dealing with the subject, it has become necessary to create new guidance for diagnosing and treating NAFLD. This guidance was prepared following an interdisciplinary study under the leadership of the Turkish Association for the Study of the Liver (TASL), Fatty Liver Special Interest Group. This new TASL Guidance is a practical application guide on NAFLD and was prepared to standardize the clinical approach to diagnosing and treating NAFLD patients. This guidance reflects many advances in the field of NAFLD. The proposals in this guidance are meant to aid decision-making in clinical practice. The guidance is primarily intended for gastroenterology, endocrinology, metabolism diseases, cardiology, internal medicine, pediatric specialists, and family medicine specialists.Publication Metadata only A case of pathologic complete response after neoadjuvant triplet chemotherapy for locally advanced colon cancer with mismatch repair enzyme proficiency(Via Medica, 2023) Kocak, Mehmet Zahid; Cakir, Murat; Kerimoglu, Ulku; Araz, Murat; Eryilmaz, Melek Karakurt; Artac, Mehmet; Yumuk, Perran Fulden; School of MedicinePatients with potentially resectable colon cancer and expected to have negative margins should undergo resection rather than neoadjuvant chemotherapy. Recent studies have suggested that neoadjuvant immunotherapy may be an option for tumors with mismatch repair enzyme deficiency (dMMR), but standard treatment for locally advanced colon cancer with mismatch repair enzyme proficiency (pMMR) is still unclear. A 37-year-old male patient was diagnosed with clinical stage IIIC (T4b N1a M0) transverse colon cancer. Mismatch repair proteins were proficient. After 3 cycles of oxaliplatin (85 mg/m(2), day 1), irinotecan (150 mg/m2, IV, day 1), leucovorin (200 mg/m(2), IV, day 1), and 5-fluorouracil (3000 mg/m(2), 46 hours of continuous infusion initiating from day 1), there was a remarkable reduction in the tumoral mass on the abdominal computed tomography. A right hemicolectomy was performed. A pathologic complete response was obtained. Although there is no consensus on which patients are suitable for neoadjuvant therapy in pMMR locally advanced colon cancer, triplet chemotherapy may be a reasonable option in selected patients.