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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only Immune compatibility of 2D bismuthene nanosheets for future combined magnetic hyperthermia and photothermal therapy(Mary Ann Liebert, Inc, 2023) Giro, Linda; Gurcan, Cansu; Gazzi, Arianna; Ekim, Okan; Ceylan, Ahmet; Unal, Mehmet Altay; Ari, Fikret; Cinar, Ozge Ozgenc; Besbinar, Omur; Yilmazer, Acelya; Delogu, Lucia Gemma; Department of Chemistry; Eroğlu, Zafer; Sündü, Buse; Metin, Önder; Department of Chemistry; Koç University Surface Science and Technology Center (KUYTAM); College of Sciences; Graduate School of Sciences and EngineeringPublication Metadata only Glioma- on-a-chip platform(Mary Ann Liebert, Inc, 2023) Department of Mechanical Engineering; Üstün, Merve; Birtek, Mehmet Tuğrul; Sokullu, Emel; Taşoğlu, Savaş; Department of Mechanical Engineering; Graduate School of Sciences and Engineering; School of Medicine; College of EngineeringPublication Metadata only The role of antimicrobial polypeptides for the predicting of urinary tract infection: UTILISE study(Springer, 2023) Yıldırım, Zeynep Yuruk; Afonso, Alberto Caldas; Akil, Ipek; Aksu, Bagdagul; Alpay, Harika; Atmis, Bahriye; Aydog, Ozlem; Bakkaloglu, Sevcan; Bayazit, Aysun Karabay; Bayram, Meral Torun; Bulut, Ipek Kaplan; Comak, Elif; Kasap-Demir, Belde; Delebe, Ozlem Cam; Bilge, İlmay; ; School of Medicine;[No abstract available]Publication Metadata only Application of HLA molecular mismatch algorithms to predict primary alloimmunity risk and rejection in paediatric kidney transplantation(Springer, 2023) Kim, Jon Jin; Fichtner, Alexander; Copley, Hannah; Krupka, Kai; Pape, Lars; Toenshoff, Burkhard; Kosmoliaptsis, Vasilis; Süsal, Caner; Koç Üniversitesi Organ Nakli İmmünoloji Araştırma Mükemmeliyet Merkezi (TIREX) / Transplant Immunology Research Centre of Excellence (TIREX); School of Medicine; Koç University Hospital[No abstract available]Publication Metadata only Assessment of HLA incompatibility at the molecular compared to antigenic HLA level enables better prediction of graft function deterioration in paediatric kidney transplantation(Springer, 2023) Kim, Jon Jin; Fichtner, Alexander; Copley, Hannah; Susal, Caner; Krupka, Kai; Pape, Lars; Burkhard, Toenshoff; Kosmoliaptsis, Vasilis; Süsal, Caner; Koç Üniversitesi Organ Nakli İmmünoloji Araştırma Mükemmeliyet Merkezi (TIREX) / Transplant Immunology Research Centre of Excellence (TIREX); School of Medicine; Koç University Hospital[No abstract available]Publication Metadata only Transforming medical students: reviewing communication skills training using OSCEs(Elsevier Ireland Ltd, 2023) Dandekar, Sucheta; Gönenli, Mehmet Gökhan; Chizzo, Jacob Harvey; ; School of Medicine;Background A structured clinical communication skills training program was introduced in 2019 at the Koc University School of Medicine. Handling sensitive issues (HSI) and breaking bad news (BBN) were introduced as two specific communication skills in the program. This study aimed to measure the effectiveness of the HSI and BBN training on students’ communication skills Method Forty-five medical students in their first clinical year were initiated into the program and randomly divided into two groups. The first group received HSI training while the second group received BBN training; one month later, they were interchanged. The training included lectures, video discussions, and role-playings. Students were trained to use NURSE statements for showing empathy, the CDC’s 5Ps approach for taking a sexual history, and the six-step SPIKES protocol for BBN. Two different OSCE stations were used to assess students after each training session. Each group encountered a scenario based on the related training; the other station presented a scenario for which they were not trained. Students were graded using a pre-validated checklist. Students also submitted written self-assessments and feedback after the two trainings were completed. The OSCE scores of both groups were analyzed and compared. Findings A total of 43 students completed the training. In both the HIS and BBN groups, the post-training OSCE mean score increased significantly. There was no significant decrease in the mean score of the OSCEs performed one month after the training. Students endorsed the training, saying it would help them face real situations in clinical settings. Discussion HSI and BBN training significantly improved the students’ communication skills. This study’s results provide evidence to stakeholders about the importance and effectiveness of the program and encourages us to redesign other communication skills lessons within the curriculum to provide the students with the most efficient and effectual training and practice.Publication Metadata only Virtual reality to improve cancer patients' quality of life: a systematic review(Oncology Nursing Soc, 2023) Aydin, Aydanur; Bağçivan, Gülcan; Özkan, Aleyna; ; School of Nursing; Graduate School of Health Sciences;Quality of life (QoL) encompasses important elements of a patients emotional, social, and physical well being. Cancer patients face psychological issues such as stress, anxiety, and depression, as well as physiological side effects such as hair loss, pain, tiredness, nausea, and vomiting, as well as social issues such as social isolation, role, and function loss, and, eventually, this worsened their quality of life. These issues cause the deterioration in the QoL of cancer...Publication Metadata only Comparative analysis of autophagy in drug responses and aggressive behavior of adult versus pediatric glioma cell lines(Oxford Univ Press Inc, 2023) ; Yenidoğan, İrem; ; School of Medicine;Abstract Central nervous system tumors are the most common solid cancer and a leading cause of cancer-related deaths in children. Glioma is the most challenging pediatric CNS tumor with therapy resistance and poor prognosis in pediatric patients. Although histopathological analyses revealed similarities with adult brain glioma, emerging evidence suggests that the deregulated molecular pathways in pediatric glioma (p-GM) are different from that of adults. Autophagy, a cellular clearance system and a drug resistance mechanism, has been implicated in glioma progression, invasion, and relapse, yet its role in pediatric patients is not well documented. In this study, we compared the autophagic capacity of adult versus p-GM cell lines and evaluated the effect of autophagy manipulation on drug responses. In addition, migration, extracellular matrix invasion ability, and the metabolism of pediatric and adult gliomas were compared and the contribution of autophagy to the aggressive phenotype was evaluated.Publication Metadata only Clinicopathologic correlations of urinary proteomic and metabolomic analysis in patients with renal aa amyloidosis and membranous nephropathy(Oxford Univ Press, 2023) Ozbek, Deniz Aral; Koc, Sila; Yet, Idil; Kablan, Sevilay; Uner, Meral; Lay, Incilay; Yıldırım, Tolga; Yılmaz, Seref Rahmi; Altun, Bulent; Küçük, Nazlı Ezgi Özkan; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); ;Background and Aims AA Amyloidosis is a multisystemic amyloidosis subtype that develops on the background of various chronic inflammatory etiologies. Urinary omics studies have become a promising tool for elucidating pathophysiology and prognosis of glomerular diseases. However, no urinary omics analysis has been performed focusing on renal AA amyloidosis in literature to the best of our knowledge. Our main aim in this study is to perform a comparative urine proteomic and metabolomic analysis of recently diagnosed renal AA amyloidosis and to investigate the correlation of bioinformatic results with clinical and pathological data. Method Urine samples of 8 recently diagnosed AA amyloidosis (AA), 8 membranous nephropathy (MN) and 6 healthy control group patients were collected before kidney biopsy procedure. Proteomic analyzes were performed with nLC/Q-TOF MS/MS and metabolomic analyzes were performed by GC/MS in all patients. Biopsy specimens were scored according to glomerulosclerosis (G), tubular atrophy (TA) and interstitial fibrosis (IF) grades by two pathologists. Raw spectroscopic data was analyzed using MaxQuant and MS-DIAL programs for proteomic and metabolomic studies, respectively. Statistical analysis of the differences in molecules between study groups were performed with ANOVA and HSD-Tukey tests. Principal component (PCA) and heatmap analyzes were made in R language, while gene ontology (GO), network and functional enrichment analysis of bioinformatic results were performed with PANTHER, STRING and MetaboAnalyst databases. Results In comparison between AA and MN groups, median eGFR values tend to be lower in the AA group (67.6 vs 112 ml/min/1.73 m2 respectively, p = 0.08). Median 24-hour urine protein levels did not show statistically significant difference (9499 vs 9512 mg/day respectively, p = 0.9). Percentage of patients with moderate/severe IF/TA was higher and G score was tend to be in AA group compared to MN group (p values 0.02 and 0.07 for IF/TA and G scores, respectively). As a result of proteomic analysis, a total of 859 proteins were determined. Statistical analysis showed 51 proteins that were significantly differ in AA group compared to the control group. GO and functional enrichment analyzes showed that statistically most significant sub-domains were mainly related with cell-cell adhesion (Figure 1 & 2). In comparative analysis between AA and MN patients, uromodulin (UMOD) was lower in the AA group than in the MN group (log2FC -3.37), whereas ribonuclease 1 (RNASE1) and α-1-microglobulin/bikunin precursor protein (AMBP) were higher in the AA group (log2FC 3.41 and 3.07, respectively). In Spearman correlation analyzes, significant negative correlations were demonstrated between UMOD-proteinuria (r = -0.48, p = 0.03) and between AMBP-eGFR (r = -0.69, p = 0.003) variables. Metabolomic analysis showed 9 metabolites that were significantly different between AA and other study groups. Myo-inositol and urate were higher in AA group compared to MN group, while D-mannitol and N-acetylglutamate were higher in AA group compared to the control group. Significant positive correlation independent of GFR was detected between RNASE1 and urate (r = 0.63, p = 0.01).Publication Metadata only The clinical and genetic characteristics of 17 cases with congenital myasthenic syndrome: data from a single center (P2-8.002)(Lippincott Williams and Wilkins, 2023) ; Yunisova, Gulshan; Akçay, Ayfer Arduç; Avcı, Şahin; Eraslan, Serpil; Kayserili, Hülya; Oflazer, Piraye; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Koç University HospitalObjective: The aim of this study to investigate the clinical and genetic features of patients with Congenital Myasthenic Syndrome (CMS) in Muscle Disease Center, Koç University Hospital, Turkey. Background: CMS is a group of hereditary disorders of impaired neuromuscular transmission characterized by fatigable muscle weakness. Design/Methods: Herein, we present the characteristics of 17 patients from 14 unrelated families. Results: The mean age (3 male, 14 female) was 18.4+13.6, the onset age ranged between the first day and the first 3 months of life in 11 cases, and 1 and 16 years in 6 patients. The most common complaints at the first 3 months were ptosis (6/11), feeding difficulty (7/11), difficulty in breathing (3/11). After the first age of life, walking late (2/6) and fatigue triggered by movement (6/6) were common. CHRNE (homozygous [c.1219+2T>G]; [c.199 G>T]; and novel [c.452_454delAGG]; heterozygous [c.1220-8+8dup and c.1327–1327delG]; [ c. .1327delG and c803-2AA and c.408+5G>A]; homozygous [c.686-2A>G]; [c.44C>T, p.]) (3 patients) and CHAT ([c.1669G>A]) (1 patient): All were ambulatory and had good response to pyridostigmine. COLQ (homozygous [14–15 exons] deletion and c.44G>A,) (3 patients ): Two siblings worsened under pyridostigmine, and had a marked response to salbutamol. The other one benefited from 3,4-diaminopyridine. AchR epsilon subunit (combined heterozygous [L240I and C302Y]) (1 patient):, She showed respiratory distress and markedly response to pyridostigmine. AGRN (novel,homozygous [c.5387G>A and C4217 A>C]) (1 Patient). She had fatigue and worsened with pyridostigmine and had a dramatic response from salbutamol. Conclusions: In our study, similar to many studies, the most common findings were ocular and bulbar symptoms, and the most common genetic disorder was postsynaptic (65%) conduction defects. Disclosure: Dr. Yunisova has nothing to disclose. Dr. ARDUC AKCAY has nothing to disclose. Dr. Avci has nothing to disclose. The institution of Dr. Eraslan has received research support from THE SCIENTIFIC AND TECHNOLOGICAL RESEARCH COUNCIL OF TURKEY. Prof. Kayserili has received research support from TUBITAK . Prof. Kayserili has received personal compensation in the range of $500-$4,999 for serving as a Projecct PI, advisor, researccher with TUBITAK . Prof. University has nothing to disclose.