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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only IDE-integrated microneedle arrays as fully biodegradable platforms for wearable/implantable capacitive biosensing(Institute of Electrical and Electronics Engineers Inc., 2023) Department of Electrical and Electronics Engineering; Ürey, Hakan; Mirzajani, Hadi; Department of Electrical and Electronics Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); College of EngineeringMicroneedle biosensors have emerged as a promising tool for in situ biomarker detection due to their minimally invasive nature and ability to interface with interstitial fluid (ISF). However, most previously demonstrated ones are limited to in situ detection of small molecules and ions, employing amperometry or potentiometry measurement techniques with electrical current or voltage output metrics, respectively, which may not be suitable for detecting large molecules, such as proteins. This letter presents an innovative approach utilizing a microneedle array integrated with an interdigitated electrode (MAIDE), enabling in situ capacitive detection and quantification of protein biomarkers. Following microneedle penetration, the interdigitated electrode array establishes direct contact with the solution, enabling real-time monitoring of interfacial capacitance modulations as the result of the binding reaction, leading to the acquisition of rich molecular data. Equivalent circuit model extraction followed by impedance spectroscopy for different concentrations of bovine serum albumin (BSA) indicated the suitability of the proposed platform in tracking the interfacial capacitance variations with respect to different BSA concentrations of 100, 10, and 1 μg/mL with a detection limit of 21 ng/mL. Furthermore, the device showed satisfactory results for biodegradability experiments where it disintegrated for a duration of 10 h. In addition, in vivo experiments show stable capacitance readings with (dC/C)% deviations less than 0.5%, indicating its potential for biodegradable wearable/implantable capacitive biosensing applicationsPublication Metadata only Optical modulation with silicon microspheres(IEEE-Inst Electrical Electronics Engineers Inc, 2009) Gürlü, Oğuzhan; N/A; Department of Physics; Yüce, Emre; Serpengüzel, Ali; Master Student; Faculty Member; Department of Physics; Graduate School of Sciences and Engineering; College of Sciences; 245435; 27855In this letter, a silicon microsphere coupled to a silica optical fiber half coupler has been characterized for electrooptical modulation in the L-band at 1.55 mu m. Electrooptical modulation of the transmitted and the 90 degrees elastic scattered signals for both the TE and the TM polarizations of the microsphere resonances has been observed.Publication Metadata only Gas adsorption and diffusion in a highly CO2 selective metal-organic framework: molecular simulations(Taylor and Francis Ltd, 2013) N/A; Department of Chemical and Biological Engineering; Keskin, Seda; Faculty Member; Department of Chemical and Biological Engineering; College of Engineering; 40548Grand canonical Monte Carlo and equilibrium molecular dynamics simulations were used to assess the performance of an rht-type metal–organic framework (MOF), Cu-TDPAT, in adsorption-based and membrane-based separation of CH4/H2, CO2/CH4 and CO2/H2 mixtures. Adsorption isotherms and self-diffusivities of pure gases and binary gas mixtures in Cu-TDPAT were computed using detailed molecular simulations. Several properties of Cu-TDPAT such as adsorption selectivity, working capacity, diffusion selectivity, gas permeability and permeation selectivity were computed and compared with well-known zeolites and MOFs. Results showed that Cu-TDPAT is a very promising adsorbent and membrane material especially for separation of CO2 and it can outperform traditional zeolites and MOFs such as DDR, MFI, CuBTC, IRMOF-1 in adsorption-based CO2/CH4 and CO2/H2 separations.Publication Metadata only Propagation of electromagnetic waves in linear media and pseudo-hermiticity(EPL Association, European Physical Society, 2008) Loran, F.; Department of Mathematics; Mostafazadeh, Ali; Faculty Member; Department of Mathematics; College of Sciences; 4231We express the electromagnetic field propagating in an arbitrary time-independent non-dispersive medium in terms of an operator that turns out to be pseudo-Hermitian for Hermitian dielectric and magnetic permeability tensors (epsilon) over left right arrow and (mu) over left right arrow. We exploit this property to determine the propagating field. In particular, we obtain an explicit expression for a planar field in an isotropic medium with (epsilon) over left right arrow = epsilon(1) over left right arrow and mu = mu(1) over left right arrow varying along the direction of the propagation. We also study the scattering of plane waves due to a localized inhomogeneity.Publication Metadata only Nanoparticle based induction heating at low magnitudes of magnetic field strengths for breast cancer therapy(Elsevier, 2019) Zuvin, Merve; Koçak, Muhammed; Akkoç, Yunus; Kutlu, Özlem; Gözüaçık, Devrim; Koşar, Ali; N/A; Department of Chemistry; Ünal, Özlem; Acar, Havva Funda Yağcı; PhD Student; Faculty Member; Department of Chemistry; Graduate School of Sciences and Engineering; College of Sciences; N/A; 178902Magnetic hyperthermia has received much attention during the last decade due to its implementation in cancer treatment. Recently, functionalized superparamagnetic iron oxide nanoparticles (SPION) emerged as a strong alternative adjuvant treatment approach, which complements conventional methods such as chemotherapy. In this study, we demonstrate the anticancer effect of Poly(acrylic acid)-coated, anti-HER2-tagged SPIONs on breast cancer cells using a low magnetic field strength of 0.8 kAm(-1), which is significantly lower compared to the literature, with a frequency of 400 kHz. Specificity was achieved via anti-HER2 antibody attachment to nanoparticles. HER2-positive SKBR3 and MDA-MB-453 cell lines internalized the nanoparticles successfully. These nanoparticles, which were not toxic to these cell lines, led to a prominent decrease in cell proliferation and survival in MDA-MB-453 cells when subjected to hyperthermia. Therefore, the hyperthermia-targeted SPION approach could be developed as a potential cancer treatment approach against breast cancer and possible other cancer types.Publication Metadata only Modeling and characterization of comb-actuated resonant microscanners(Iop Publishing Ltd, 2006) N/A; Department of Electrical and Electronics Engineering; Ataman, Çağlar; Ürey, Hakan; PhD Student; Faculty Member; Department of Electrical and Electronics Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; 8579The dynamics of the out-of-plane comb-drive actuator used in a torsional resonant mode microscanner is discussed. The microscanner is fabricated using the standard SOI technology by Fraunhofer, IPMS and utilized in various display, barcode scanning, spectroscopy and other imaging applications. The device is a parametrically excited system and exhibits hysteretic frequency response, nonlinear transient response, subharmonic oscillations, multiple parametric resonances, and alternating-oscillation-frequency behavior. Analytical and numerical models are developed to predict the parametric system dynamics. The analytical model is based on the solution of the linear Mathieu equation and valid for small angular displacements. The numerical model is valid for both small and large deflection angles. The analytical and numerical models are validated with the experimental results under various ambient pressures and excitation schemes and successfully predict the dynamics of the parametric nature of the microscanner. As many as four parametric resonances are observed at 30 mTorr. The models developed in this paper can be used to optimize the structure and the actuator.Publication Metadata only Modeling the role of external stresses on the austenite-to-bainite phase transformation in 51CrV4 steel(Institute of Physics (IOP) Publishing, 2011) Lambers, H-G; Tschumak, S.; Maier, H. J.; N/A; Department of Mechanical Engineering; Uslu, Mehmet Can; Canadinç, Demircan; Master Student; Faculty Member; Department of Mechanical Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; 23433A new model is proposed to successfully predict the initiation and evolution of the austenite-to-bainite phase transformation, capturing specifically the time-dependent transformation kinetics. In particular, the isothermal bainitic transformation in 51CrV4 steel is experimentally observed for various constant stress conditions, and significant improvement is obtained in comparison with the existing models. Specifically, both the transformation kinetics and the resultant transformation strains can be simultaneously predicted using the same variant growth approach. Simulation results are in good agreement with the experiments, evidencing the success of the proposed model in describing the transformation phenomena in terms of kinetics and transformation plasticity. Furthermore, the proposed formulation provides a basis for incorporating variant-variant interactions and cementite formation in the residual austenite matrix.Publication Metadata only Quenching vibrations of cesium dimers by He at low and ultralow temperatures: quantum dynamical calculations(Springer, 2011) Caruso, D.; Tacconi, M.; Bovino, S.; Gianturco, F. A.; Department of Chemistry; Yurtsever, İsmail Ersin; Faculty Member; Department of Chemistry; College of Sciences; 7129This paper analyses in detail the energy redistribution from the upper vibrational levels of Cs dimers, thought to be obtained from initial recombination processes that generate excited internal states of the triplet configuration (3) I pound (u) (+) . Their quenching is examined as they are made to further collide with (4)He buffer gas at temperatures below and around 100 mK. The relevant cross sections are computed by using a multichannel quantum dynamical approach and employ a full, ab initio potential energy surface. Due to their smallness (see Ref. [R.B. Ross, J.M. Powers, T. Atashroo, W.C. Ermler, I.A. LaJohn, P. Christiansen, J. Chem. Phys. 93, 6654 (1999)]) the fine structure effects have not been explicitly included in this study. The final, cumulative cross-sections are discussed and analyzed in terms of the overall quenching behavior shown by different initial states of the dimer and in terms of the changing ratios between collisional cooling and vibrational quenching cross sections as a function of trap temperature. The corresponding quenching rates are also computed and analysed.Publication Metadata only Design principles of q-preserving multipass-cavity femtosecond lasers(The Optical Society (OSA) Publishing, 2006) Kowalevicz, A.M.; Zare, A.T.; Fujimoto, J.G.; Department of Physics; Sennaroğlu, Alphan; Faculty Member; Department of Physics; College of Sciences; 23851We describe a new class of femtosecond laser cavity designs that are based on a Herriott-type multipass cavity (MPC) to effectively increase the length of a standard laser resonator. MPC laser designs can be used to increase the output pulse energies or to make more compact resonator configurations. A general theory for MPC lasers is developed by analyzing a periodic optical system, and the conditions are established for the case in which the q parameter of a Gaussian beam is left invariant after a single transit through the system. On the basis of this analysis, we determine the design criteria for two-mirror q-preserving MPCs. Practical laser cavity choices are presented and their trade-offs are examined. We also discuss various experimental setups that use these novel MPC designs to increase pulse energies while maintaining compact cavities.Publication Metadata only Structuring a quantum solvent around a weakly bound dopant: the He-Cs2((3)sigma u) complex(2009) Prosmiti, Rita; Delgado-Barrio, Gerardo; Villarreal, Pablo; Coccia, Emanuele; Gianturco, Franco A.; Department of Chemistry; Yurtsever, İsmail Ersin; Faculty Member; Department of Chemistry; College of Sciences; 7129The structure and energetics of 3,4HeCs2(3Σu) molecules are analyzed from first principles. Fixing the cesium dimer at its equilibrium distance, the electronic structure was determined through ab initio methods at the CCSD(T) level of theory using a large basis set to compute the interaction energies. At the T-shaped geometry, there is a shallow well with a depth of ∼2 cm−1 placed at R ∼6.75 Å, R being the distance from the center of mass of Cs2 to He. That depth gradually decreases to ∼0.75 cm−1, while R increases to about 11.5 Å at linear arrangements. A simple model of adding atom−atom Lennard-Jones potentials with well-depth and equilibrium distance parameters depending on the angular orientation was found to accurately reproduce the ab initio points. Using this analytical form, variational calculations at zero total angular momentum are performed, predicting a single bound level at ∼−0.106 (∼−0.042) cm−1 for the boson (fermion) species. Further calculations using Quantum Monte Carlo methods are carried out and found to be in good agreement with the variational ones. On the basis of the present results, such analytical expression could in turn be used to describe the structure and binding of larger complexes and therefore opens the possibility to further studies involving such aggregates.