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Permanent URI for this communityhttps://hdl.handle.net/20.500.14288/2
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Publication Metadata only Microfluidic pulse shaping methods for molecular communications(Elsevier B.V., 2023) N/A; Department of Electrical and Electronics Engineering; N/A; N/A; Kuşcu, Murat; Kahvazi Zadeh, Maryam; Bolhassan, Iman Mokari; Faculty Member; Master Student; PhD Student; Department of Electrical and Electronics Engineering; College of Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; 316349; N/A; N/AMolecular Communication (MC) is a bio-inspired communication modality that utilizes chemical signals in the form of molecules to exchange information between spatially separated entities. Pulse shaping is an important process in all communication systems, as it modifies the waveform of transmitted signals to match the characteristics of the communication channel for reliable and high-speed information transfer. In MC systems, the unconventional architectures of components, such as transmitters and receivers, and the complex, nonlinear, and time-varying nature of MC channels make pulse shaping even more important. While several pulse shaping methods have been theoretically proposed for MC, their practicality and performance are still uncertain. Moreover, the majority of recently proposed experimental MC testbeds that rely on microfluidics technology lack the incorporation of programmable pulse shaping methods, which hinders the accurate evaluation of MC techniques in practical settings. To address the challenges associated with pulse shaping in microfluidic MC systems, we provide a comprehensive overview of practical microfluidic chemical waveform generation techniques that have been experimentally validated and whose architectures can inform the design of pulse shaping methods for microfluidic MC systems and testbeds. These techniques include those based on hydrodynamic and acoustofluidic force fields, as well as electrochemical reactions. We also discuss the fundamental working mechanisms and system architectures of these techniques, and compare their performances in terms of spatiotemporal resolution, selectivity, system complexity, and other performance metrics relevant to MC applications, as well as their feasibility for practical MC applications.Publication Metadata only Molecular communication transmitter architectures for the internet of bio-nano things(Institute of Electrical and Electronics Engineers Inc., 2022) Department of Electrical and Electronics Engineering; N/A; Akan, Özgür Barış; Civaş, Meltem; Faculty Member; PhD Student; Department of Electrical and Electronics Engineering; College of Engineering; Graduate School of Sciences and Engineering; 6647; N/AIn this study, we investigate the nanomaterial-based approach for developing practical molecular communication transmitters (MC-Txs) for the Internet of Bio-Nano Things (IoBNT) applications, which are expected to be unconventional in many aspects. In particular, we focus on the most pressing challenges for MC-Tx architectures, namely controlling information molecule release and molecule replenishment, together with other aspects, selective molecule release and molecule leakage mitigation. We discuss promising nanomaterials and also identify potential challenges and research directions.Publication Metadata only Narrow escape problem in synaptic molecular communications(Association for Computing Machinery, Inc, 2022) Koca, Çağlar; Department of Electrical and Electronics Engineering; N/A; Akan, Özgür Barış; Civaş, Meltem; Faculty Member; PhD Student; Department of Electrical and Electronics Engineering; College of Engineering; Graduate School of Sciences and Engineering; 6647; N/AThe narrow escape problem (NEP) is a well-known problem with many applications in cellular biology. It is especially important to understand synaptic molecular communications. Active regions of synapses, also known as apposition zones, are connected to synaptic cleft through narrow slits, from which neurotransmitters can escape to or return from the cleft into the apposition zones. While neurotransmitters leakage into the cleft might be desired for the reuptake process, escaping neurotransmitters might trigger an undesired, i.e., false-positive or action potential in the post-synaptic terminal. Obtaining analytic solutions to NEPs is very challenging due to its geometry dependency. Slight alterations in either or both shape or the size of the hole and the outer volume may cause drastic changes in the solution. Thus, we need a simulation-based approach to solve NEPs. However, NEP also requires the size of the hole to be much smaller than the dimensions of the volume. Combined with the requirement for Brownian motion, where the step size is much smaller than the dimensions of the volume, simulations can be prohibitively long, even for modern computers. Therefore, in this work, we suggest a simulation algorithm that simultaneously satisfies the NEP and Brownian motion simulation requirements. Our simulation framework can be used to quantify the neurotransmitter leakage within synaptic clefts.